Abstract：
:Hyperimmune rat antisera prepared against 5 recent antigenic variants of influenza A (H3N2) viruses were studied for haemagglutination inhibiting (HI) antibodies to the homologous and the heterologous viruses. The ratios of homologous to heterologous reactions varied from one animal to another in immunizations with each of the immunogens. Some antisera exhibited a ratio high enough to allow differentiation of the epidemic variants and demonstration of an intraepidemic heterogeneity of field strains isolated during the outbreak of 1985/86. The variation of cross-reactions of polyclonal antisera may reflect differences in the range of specificities of anti-haemagglutinin antibodies produced by individual animals. The significance of this finding in the classification of influenza A (H3N2) viruses is discussed. Lack of nonspecific inhibitors interfering with the HI test is an additional advantage of hyperimmune rat antisera in typing influenza A and B virus isolates.
journal_name
J Virol Methodsjournal_title
Journal of virological methodsauthors
Pyhälä R,Pyhälä Ldoi
10.1016/0166-0934(87)90147-9subject
Has Abstractpub_date
1987-03-01 00:00:00pages
259-65issue
4eissn
0166-0934issn
1879-0984pii
0166-0934(87)90147-9journal_volume
15pub_type
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journal_title：Journal of virological methods
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doi：10.1016/s0166-0934(99)00041-5
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journal_title：Journal of virological methods
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doi：10.1016/s0166-0934(99)00064-6
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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更新日期：1989-09-01 00:00:00
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
pub_type： 杂志文章
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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doi：10.1016/0166-0934(90)90011-4
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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journal_title：Journal of virological methods
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更新日期：1990-03-01 00:00:00
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journal_title：Journal of virological methods
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更新日期：2009-02-01 00:00:00
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journal_title：Journal of virological methods
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
abstract：:The ongoing Zika virus (ZIKV) outbreak has rapidly spread to new areas of Americas, which were the first transmissions outside its traditional endemic areas in Africa and Asia. Due to the link with newborn defects and neurological disorder, numerous infected cases throughout the world and various mosquito vectors, the...
journal_title：Journal of virological methods
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
