Abstract:
:The reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been studied in animal models and in human populations. In animals, TCDD has a range of toxic effects on organs of the reproductive system in males and females, on hormone biochemistry, and on embryo-fetal development. These effects may involve in part an identified intracellular TCDD receptor and its association with the induction of microsomal cytochrome P-450-dependent monooxygenases in many organs. TCDD treatment increases activity of monooxygenase enzyme in liver and gonads of treated animals, but unlike other polycyclic aromatic hydrocarbons that are monooxygenase inducers, TCDD is not cytotoxic to any population of oocytes in the mature female mouse. Epidemiological studies of TCDD reproductive toxicity have been limited in design. There are some reports of adverse effects in the Seveso population and in children born to American veterans presumed to have been exposed to TCDD in Agent Orange during the Vietnam war. Occupational cohorts have not been found to show such paternally mediated effects of TCDD exposure.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Silbergeld EK,Mattison DRdoi
10.1002/ajim.4700110203subject
Has Abstractpub_date
1987-01-01 00:00:00pages
131-44issue
2eissn
0271-3586issn
1097-0274journal_volume
11pub_type
杂志文章,评审abstract:BACKGROUND:Latex allergy is poorly understood in latex-exposed textile workers. METHODS:A cross-sectional study was carried out to better characterize respiratory symptoms, using personal breathing zone latex allergen measurement and specific IgE to latex allergens. RESULTS:Forty-four of the 86 (51% participation rat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22050
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:There are few population-based studies addressing hypersensitivity pneumonitis (HP) in the United States. The National Institute for Occupational Safety and Health (NIOSH) has nationally comprehensive longitudinal mortality data that can contribute to a better understanding of the epidemiology of HP. METHOD...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20405
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:After cryptosporidiosis was reported in three workers caring for preweaned calves at an academic research laboratory, we sought to identify cases, determine risk factors, and implement control measures. METHODS:A cryptosporidiosis case was defined as diarrhea duration ≥72 hr, abdominal cramps, or vomiting i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22630
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate cancer incidence in the membership a largely Hispanic farmworker labor union in California, the United Farmworkers of America (UFW) and to examine cancer-site specific distributions as well as histology and stage of cancer at diagnosis in this group. METHODS:An elec...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1125
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS:A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and back...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22790
更新日期:2018-01-01 00:00:00
abstract::Since 1988, the National Institute for Occupational Safety and Health (NIOSH) has notified workers who were subjects in occupational epidemiology studies of the study findings ("worker notification"). This paper describes seven notifications and the worker's reactions to them. The chemicals of interest in the studies ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270403
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS:Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide prod...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20086
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:The Mine Safety and Health Administration (MSHA) proposes to issue citations for non-compliance with the exposure limit for respirable coal mine dust when measured exposure exceeds the exposure limit with a "high degree of confidence." This criterion threshold value (CTV) is derived from the sampling and ana...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20318
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Construction workers move frequently from jobsite to jobsite, yet little is documented about length of stay on-site and associations with worker characteristics. METHOD:Using cross-sectional data, we investigated associations between worker characteristics (including trade and musculoskeletal pain) and leng...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22461
更新日期:2015-09-01 00:00:00
abstract::In order to determine the possible actual exposure to benzene in the shoe industry from industrially used solvents, glues, and paints containing benzene as a nondeclared constituent, phenol in urine and benzene in blood, as indices of internal exposure to benzene, were measured in workers (N = 33). Since toluene, in c...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120507
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Existing research suggests that workplace injuries can have significant economic and social consequences for workers; but there are no quantitative studies on complete populations. METHODS:The British Columbia Linked Health Database (BCLHD) was used to examine 1994 injured workers who lost work time due to ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20503
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:This study examines the hypothesis that acid mist or mixtures of acid mists and acid gases are associated with ulcerative lesions of the oral mucosa. METHODS:All 665 active male workers of a metal processing factory were the study population. Semi-quantitative measures of exposure were estimated from a job ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10343
更新日期:2004-03-01 00:00:00
abstract::To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230209
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Nearly one of every three workers in the United States is low-income. Low-income populations have a lower life expectancy and greater rates of chronic diseases compared to those with higher incomes. Low- income workers face hazards in their workplaces as well as in their communities. Developing integrated pu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22174
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:A number of employees at an aircraft factory were accidentally exposed to hydrogen sulfide. Because of concern that this may have resulted in lung injury, forty-seven workers were referred for clinical and physiological evaluation. METHODS:Comprehensive pulmonary function tests were performed including spir...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0274(200003)37:3<296::aid-ajim8
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:In studies in men, risk estimates on occupation and bladder cancer are distorted by about 10% when not adjusting for smoking. We examined the degree to which occupational risk estimates for bladder cancer in women are confounded by smoking, and the degree of residual confounding by inadequate control of this...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/(sici)1097-0274(199907)36:1<75::aid-ajim11
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20594
更新日期:2008-08-01 00:00:00
abstract::Long-term exposure to lead is known to cause a variety of neurotoxic manifestations, including symptoms of depression. Dimercaptosuccinic acid (DMSA), a recently approved oral chelating agent, can diminish the body burden of lead, but few cases of documented clinical improvement following treatment have been reported....
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700240606
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:We sought to gain insight into workers' knowledge, beliefs, and attitudes on the subject of testing for genetic susceptibility to beryllium. METHODS:Five focus groups were held with 30 current and former beryllium workers and nine family members. Audio recordings were transcribed and assessed by hierarchica...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20962
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Occupational Cancer Monitoring (OCCAM) is an Italian organization that monitors occupational cancers, by area and industrial sector, by retrieving cases and employment history from official databases. OCCAM previously estimated a relative risk (RR) of lung cancer of about 1.32 among "metal treatment" workers...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.21004
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Construction is a dangerous industry with a large number of small businesses. Because they require minimal resources to deliver, toolbox talks may be an ideal training format for small construction contractors. METHODS:Eight toolbox talks were developed, each with two versions. One version of each toolbox t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/ajim.22919
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Pulmonary tuberculosis and HIV incidence, mortality, and the progression of silicosis and lung function impairment are described over a 1-year period in migrant ex-gold miners from Lesotho. METHODS:Seven hundred seventy-nine Basotho miners were followed for 1 year starting 18 months after lay-off from a Sou...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20767
更新日期:2009-12-01 00:00:00
abstract::A five-year total community study of lung cancer incidence by occupation revealed that 1) virtually all the cases occurred in smokers; 2) all major histologic types of lung cancer were strongly associated with smoking behavior; 3) in most high-risk occupations the significant elevations of risk were limited to one or ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700030409
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tubercul...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23066
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Persistent and growing occupation-based disparities related to tobacco pose a serious public health challenge. Tobacco exacts a disproportionate toll on individuals employed in working class occupations, due to higher prevalence of smoking and exposure to secondhand smoke among these workers compared to othe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20026
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Hispanic immigrant workers dominate California's hired farm workforce. Little is known about their health status; even less is known about those lacking employment authorization. METHODS:The California Agricultural Workers Health Survey (CAWHS) was a statewide cross-sectional household survey conducted in 1...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20796
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To compare fatal and hospitalized nonfatal work-related traumatic injuries by occupation and cause. METHODS:Fatal and hospitalized nonfatal injuries occurring from 1991-1995 were identified from Washington State workers' compensation claims data. Nonfatal injuries were classified as severe if they had at lea...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199908)36:2<317::aid-ajim1
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Investigations of breast cancer among men may provide clues for environmental and occupational risk factors that may be difficult to study in women, because of confounding or effect modification from reproductive female characteristics. The objective was to estimate occupation-specific risks of male breast c...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/1097-0274(200103)39:3<276::aid-ajim1015>3.
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Work-related musculoskeletal disorders (MSDs) of the upper extremities are a major problem globally, though most relevant studies have been reported from high income countries. AIMS AND METHODS:The prevalence of neck and shoulder pain and its association with work-related physical and psychosocial factors a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20562
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Symptoms of post-traumatic stress disorder (PTSD) have been reported even years after the terrorist attacks of September 11, 2001 (9/11). METHODS:We used screening tools to assess the prevalence of probable PTSD in 9/11-exposed firefighters at two time points, within 6 months of 9/11 (baseline) and 3-4 year...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20894
更新日期:2010-12-01 00:00:00