Experimental and clinical studies on the reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Abstract:

:The reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been studied in animal models and in human populations. In animals, TCDD has a range of toxic effects on organs of the reproductive system in males and females, on hormone biochemistry, and on embryo-fetal development. These effects may involve in part an identified intracellular TCDD receptor and its association with the induction of microsomal cytochrome P-450-dependent monooxygenases in many organs. TCDD treatment increases activity of monooxygenase enzyme in liver and gonads of treated animals, but unlike other polycyclic aromatic hydrocarbons that are monooxygenase inducers, TCDD is not cytotoxic to any population of oocytes in the mature female mouse. Epidemiological studies of TCDD reproductive toxicity have been limited in design. There are some reports of adverse effects in the Seveso population and in children born to American veterans presumed to have been exposed to TCDD in Agent Orange during the Vietnam war. Occupational cohorts have not been found to show such paternally mediated effects of TCDD exposure.

journal_name

Am J Ind Med

authors

Silbergeld EK,Mattison DR

doi

10.1002/ajim.4700110203

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

131-44

issue

2

eissn

0271-3586

issn

1097-0274

journal_volume

11

pub_type

杂志文章,评审
  • Bespoke latex allergen testing improves assessment of respiratory symptoms in textile-braiding workers.

    abstract:BACKGROUND:Latex allergy is poorly understood in latex-exposed textile workers. METHODS:A cross-sectional study was carried out to better characterize respiratory symptoms, using personal breathing zone latex allergen measurement and specific IgE to latex allergens. RESULTS:Forty-four of the 86 (51% participation rat...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22050

    authors: Harris-Roberts J,Tate P,Robinson E,Griffin P,Mason H,Barber C,Curran AD,Fishwick D

    更新日期:2012-07-01 00:00:00

  • Twenty-three years of hypersensitivity pneumonitis mortality surveillance in the United States.

    abstract:BACKGROUND:There are few population-based studies addressing hypersensitivity pneumonitis (HP) in the United States. The National Institute for Occupational Safety and Health (NIOSH) has nationally comprehensive longitudinal mortality data that can contribute to a better understanding of the epidemiology of HP. METHOD...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20405

    authors: Bang KM,Weissman DN,Pinheiro GA,Antao VC,Wood JM,Syamlal G

    更新日期:2006-12-01 00:00:00

  • Cryptosporidiosis outbreak at an academic animal research laboratory-Colorado, 2014.

    abstract:BACKGROUND:After cryptosporidiosis was reported in three workers caring for preweaned calves at an academic research laboratory, we sought to identify cases, determine risk factors, and implement control measures. METHODS:A cryptosporidiosis case was defined as diarrhea duration ≥72 hr, abdominal cramps, or vomiting i...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22630

    authors: Hancock-Allen J,Alden NB,Cronquist AB

    更新日期:2017-02-01 00:00:00

  • Cancer incidence in the United Farmworkers of America (UFW), 1987-1997.

    abstract:BACKGROUND:The purpose of this study was to evaluate cancer incidence in the membership a largely Hispanic farmworker labor union in California, the United Farmworkers of America (UFW) and to examine cancer-site specific distributions as well as histology and stage of cancer at diagnosis in this group. METHODS:An elec...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.1125

    authors: Mills PK,Kwong S

    更新日期:2001-11-01 00:00:00

  • DNA variants and organophosphate neurotoxicity among emerging farmers in the Western Cape of South Africa.

    abstract:BACKGROUND:Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS:A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and back...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22790

    authors: Glass T,Dalvie MA,Holtman Z,Vorster AA,Ramesar RS,London L

    更新日期:2018-01-01 00:00:00

  • Workers' response to risk notification.

    abstract::Since 1988, the National Institute for Occupational Safety and Health (NIOSH) has notified workers who were subjects in occupational epidemiology studies of the study findings ("worker notification"). This paper describes seven notifications and the worker's reactions to them. The chemicals of interest in the studies ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700270403

    authors: Boal WL,Friedland J,Schulte PA

    更新日期:1995-04-01 00:00:00

  • IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study.

    abstract:BACKGROUND:The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS:Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide prod...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20086

    authors: Doekes G,Larsen P,Sigsgaard T,Baelum J

    更新日期:2004-10-01 00:00:00

  • The Mine Safety and Health Administration's criterion threshold value policy increases miners' risk of pneumoconiosis.

    abstract:BACKGROUND:The Mine Safety and Health Administration (MSHA) proposes to issue citations for non-compliance with the exposure limit for respirable coal mine dust when measured exposure exceeds the exposure limit with a "high degree of confidence." This criterion threshold value (CTV) is derived from the sampling and ana...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20318

    authors: Weeks JL

    更新日期:2006-06-01 00:00:00

  • Length of time spent working on a commercial construction site and the associations with worker characteristics.

    abstract:BACKGROUND:Construction workers move frequently from jobsite to jobsite, yet little is documented about length of stay on-site and associations with worker characteristics. METHOD:Using cross-sectional data, we investigated associations between worker characteristics (including trade and musculoskeletal pain) and leng...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22461

    authors: Sparer EH,Okechukwu CA,Manjourides J,Herrick RF,Katz JN,Dennerlein JT

    更新日期:2015-09-01 00:00:00

  • Occupational exposure to benzene in the shoe industry.

    abstract::In order to determine the possible actual exposure to benzene in the shoe industry from industrially used solvents, glues, and paints containing benzene as a nondeclared constituent, phenol in urine and benzene in blood, as indices of internal exposure to benzene, were measured in workers (N = 33). Since toluene, in c...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700120507

    authors: Karacić V,Skender L,Prpić-Majić D

    更新日期:1987-01-01 00:00:00

  • Social and economic consequences of workplace injury: a population-based study of workers in British Columbia, Canada.

    abstract:BACKGROUND:Existing research suggests that workplace injuries can have significant economic and social consequences for workers; but there are no quantitative studies on complete populations. METHODS:The British Columbia Linked Health Database (BCLHD) was used to examine 1994 injured workers who lost work time due to ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20503

    authors: Brown JA,Shannon HS,Mustard CA,McDonough P

    更新日期:2007-09-01 00:00:00

  • Occupational exposures to acid mists and gases and ulcerative lesions of the oral mucosa.

    abstract:BACKGROUND:This study examines the hypothesis that acid mist or mixtures of acid mists and acid gases are associated with ulcerative lesions of the oral mucosa. METHODS:All 665 active male workers of a metal processing factory were the study population. Semi-quantitative measures of exposure were estimated from a job ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.10343

    authors: Vianna MI,Santana VS,Loomis D

    更新日期:2004-03-01 00:00:00

  • Socioeconomic and health status of electronics workers employed in organized industry.

    abstract::To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status o...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700230209

    authors: Mathur N,Gupta BN,Rastogi SK,Mahendra PN,Pangtey BS,Husain T,Bharti RS

    更新日期:1993-02-01 00:00:00

  • Promoting integrated approaches to reducing health inequities among low-income workers: applying a social ecological framework.

    abstract:BACKGROUND:Nearly one of every three workers in the United States is low-income. Low-income populations have a lower life expectancy and greater rates of chronic diseases compared to those with higher incomes. Low- income workers face hazards in their workplaces as well as in their communities. Developing integrated pu...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22174

    authors: Baron SL,Beard S,Davis LK,Delp L,Forst L,Kidd-Taylor A,Liebman AK,Linnan L,Punnett L,Welch LS

    更新日期:2014-05-01 00:00:00

  • Is a reduction in residual volume a sub-clinical manifestation of hydrogen sulfide intoxication?

    abstract:BACKGROUND:A number of employees at an aircraft factory were accidentally exposed to hydrogen sulfide. Because of concern that this may have resulted in lung injury, forty-seven workers were referred for clinical and physiological evaluation. METHODS:Comprehensive pulmonary function tests were performed including spir...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0274(200003)37:3<296::aid-ajim8

    authors: Buick JB,Lowry RC,Magee TR

    更新日期:2000-03-01 00:00:00

  • Smoking as a confounder in case-control studies of occupational bladder cancer in women.

    abstract:BACKGROUND:In studies in men, risk estimates on occupation and bladder cancer are distorted by about 10% when not adjusting for smoking. We examined the degree to which occupational risk estimates for bladder cancer in women are confounded by smoking, and the degree of residual confounding by inadequate control of this...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,meta分析

    doi:10.1002/(sici)1097-0274(199907)36:1<75::aid-ajim11

    authors: 't Mannetje A,Kogevinas M,Chang-Claude J,Cordier S,González CA,Hours M,Jöckel KH,Bolm-Audorff U,Lynge E,Porru S,Donato F,Ranft U,Serra C,Tzonou A,Vineis P,Wahrendorf J,Boffetta P

    更新日期:1999-07-01 00:00:00

  • Longitudinal respiratory health study of the wood processing industry.

    abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20594

    authors: Glindmeyer HW,Rando RJ,Lefante JJ,Freyder L,Brisolara JA,Jones RN

    更新日期:2008-08-01 00:00:00

  • Dimercaptosuccinic acid in the treatment of depression following lead exposure.

    abstract::Long-term exposure to lead is known to cause a variety of neurotoxic manifestations, including symptoms of depression. Dimercaptosuccinic acid (DMSA), a recently approved oral chelating agent, can diminish the body burden of lead, but few cases of documented clinical improvement following treatment have been reported....

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700240606

    authors: Frumkin H,Gerr F

    更新日期:1993-12-01 00:00:00

  • Genetic susceptibility testing for beryllium: worker knowledge, beliefs, and attitudes.

    abstract:BACKGROUND:We sought to gain insight into workers' knowledge, beliefs, and attitudes on the subject of testing for genetic susceptibility to beryllium. METHODS:Five focus groups were held with 30 current and former beryllium workers and nine family members. Audio recordings were transcribed and assessed by hierarchica...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20962

    authors: Silver K,Kukulka G,Gorniewicz J,Rayman K,Sharp R

    更新日期:2011-07-01 00:00:00

  • Lung cancer risk in the electroplating industry in Lombardy, Italy, using the Italian occupational cancer monitoring (OCCAM) information system.

    abstract:BACKGROUND:Occupational Cancer Monitoring (OCCAM) is an Italian organization that monitors occupational cancers, by area and industrial sector, by retrieving cases and employment history from official databases. OCCAM previously estimated a relative risk (RR) of lung cancer of about 1.32 among "metal treatment" workers...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.21004

    authors: Panizza C,Bai E,Oddone E,Scaburri A,Massari S,Modonesi C,Contiero P,Marinaccio A,Crosignani P

    更新日期:2012-01-01 00:00:00

  • Evaluation of toolbox safety training in construction: The impact of narratives.

    abstract:BACKGROUND:Construction is a dangerous industry with a large number of small businesses. Because they require minimal resources to deliver, toolbox talks may be an ideal training format for small construction contractors. METHODS:Eight toolbox talks were developed, each with two versions. One version of each toolbox t...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ajim.22919

    authors: Eggerth DE,Keller BM,Cunningham TR,Flynn MA

    更新日期:2018-12-01 00:00:00

  • Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners.

    abstract:BACKGROUND:Pulmonary tuberculosis and HIV incidence, mortality, and the progression of silicosis and lung function impairment are described over a 1-year period in migrant ex-gold miners from Lesotho. METHODS:Seven hundred seventy-nine Basotho miners were followed for 1 year starting 18 months after lay-off from a Sou...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20767

    authors: Park HH,Girdler-Brown BV,Churchyard GJ,White NW,Ehrlich RI

    更新日期:2009-12-01 00:00:00

  • Histologic differences in occupational risks of lung cancer incidence.

    abstract::A five-year total community study of lung cancer incidence by occupation revealed that 1) virtually all the cases occurred in smokers; 2) all major histologic types of lung cancer were strongly associated with smoking behavior; 3) in most high-risk occupations the significant elevations of risk were limited to one or ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700030409

    authors: Morton WE,Treyve EL

    更新日期:1982-01-01 00:00:00

  • Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects.

    abstract:INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tubercul...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23066

    authors: Salum KCR,de Castro MCS,Moreira VB,Nani ASF,Kohlrausch FB

    更新日期:2020-01-01 00:00:00

  • Reducing occupation-based disparities related to tobacco: roles for occupational health and organized labor.

    abstract:BACKGROUND:Persistent and growing occupation-based disparities related to tobacco pose a serious public health challenge. Tobacco exacts a disproportionate toll on individuals employed in working class occupations, due to higher prevalence of smoking and exposure to secondhand smoke among these workers compared to othe...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20026

    authors: Barbeau EM,McLellan D,Levenstein C,DeLaurier GF,Kelder G,Sorensen G

    更新日期:2004-08-01 00:00:00

  • The health of California's immigrant hired farmworkers.

    abstract:BACKGROUND:Hispanic immigrant workers dominate California's hired farm workforce. Little is known about their health status; even less is known about those lacking employment authorization. METHODS:The California Agricultural Workers Health Survey (CAWHS) was a statewide cross-sectional household survey conducted in 1...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20796

    authors: Villarejo D,McCurdy SA,Bade B,Samuels S,Lighthall D,Williams D 3rd

    更新日期:2010-04-01 00:00:00

  • Comparison of fatal and severe nonfatal traumatic work-related injuries in Washington state.

    abstract:OBJECTIVE:To compare fatal and hospitalized nonfatal work-related traumatic injuries by occupation and cause. METHODS:Fatal and hospitalized nonfatal injuries occurring from 1991-1995 were identified from Washington State workers' compensation claims data. Nonfatal injuries were classified as severe if they had at lea...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199908)36:2<317::aid-ajim1

    authors: Alexander BH,Franklin GM,Fulton-Kehoe D

    更新日期:1999-08-01 00:00:00

  • Breast cancer, occupation, and exposure to electromagnetic fields among Swedish men.

    abstract:BACKGROUND:Investigations of breast cancer among men may provide clues for environmental and occupational risk factors that may be difficult to study in women, because of confounding or effect modification from reproductive female characteristics. The objective was to estimate occupation-specific risks of male breast c...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/1097-0274(200103)39:3<276::aid-ajim1015>3.

    authors: Pollán M,Gustavsson P,Floderus B

    更新日期:2001-03-01 00:00:00

  • Occupational neck and shoulder pain among automobile manufacturing workers in Iran.

    abstract:BACKGROUND:Work-related musculoskeletal disorders (MSDs) of the upper extremities are a major problem globally, though most relevant studies have been reported from high income countries. AIMS AND METHODS:The prevalence of neck and shoulder pain and its association with work-related physical and psychosocial factors a...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20562

    authors: Alipour A,Ghaffari M,Shariati B,Jensen I,Vingard E

    更新日期:2008-05-01 00:00:00

  • Longitudinal study of probable post-traumatic stress disorder in firefighters exposed to the World Trade Center disaster.

    abstract:BACKGROUND:Symptoms of post-traumatic stress disorder (PTSD) have been reported even years after the terrorist attacks of September 11, 2001 (9/11). METHODS:We used screening tools to assess the prevalence of probable PTSD in 9/11-exposed firefighters at two time points, within 6 months of 9/11 (baseline) and 3-4 year...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20894

    authors: Berninger A,Webber MP,Niles JK,Gustave J,Lee R,Cohen HW,Kelly K,Corrigan M,Prezant DJ

    更新日期:2010-12-01 00:00:00