Abstract：
:Valine-proline-aspartate-proline-arginine (VPDPR), the amino terminal pentapeptide of pancreatic procolipase, produced a dose-dependent reduction in food intake when injected intraperitoneally into Osborne-Mendel rats that had been starved overnight. This inhibition of feeding was observed when the rats were fed a high-fat diet but not in rats fed a high-carbohydrate, low-fat diet. At higher doses of VPDPR, the inhibition of feeding was maintained for over 6 hours. An equimolar mixture of the free amino acids had no effect on food intake. In rats adapted to a three-choice macronutrient diet, VPDPR inhibited fat intake but had no effect on carbohydrate or protein intake. This selective inhibition of fat intake was observed in both overnight-fasted rats presented with food and in ad-lib-fed rats at the beginning of the dark-onset feeding period. It is suggested that this peptide may be a feedback signal to regulate the intake of dietary fat.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Okada S,York DA,Bray GA,Erlanson-Albertsson Cdoi
10.1016/0031-9384(91)90349-ssubject
Has Abstractpub_date
1991-06-01 00:00:00pages
1185-9issue
6eissn
0031-9384issn
1873-507Xpii
0031-9384(91)90349-Sjournal_volume
49pub_type
杂志文章abstract：:Olfactory bulbectomy (OBX) is a well known screening model for depression. Panax quinquefolium (PQ) is known for its therapeutic potential against several psychiatric disorders. Nitric oxide (NO), an intercellular messenger has been suggested to play a crucial role in the pathogenesis of depression. The present study ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.037
更新日期：2014-04-22 00:00:00
abstract：:The development of the metabolic syndrome in an increasing percentage of the populations of Western societies, particularly in the United States, requires valid models for establishing basic biochemical changes and performing preclinical studies on potential drug targets. The C57BL/6J mouse has become an important mod...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2004.02.006
更新日期：2004-04-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of death worldwide and hypertension is the most common risk factor for death. Although many anti-hypertensive pharmacotherapies are approved for use in the United States, rates of hypertension have increased over the past decade. This review article summarizes a presentation...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2016.01.020
更新日期：2016-08-01 00:00:00
abstract：:The effects of castration on male spawning behavior, nestbuilding and fertility were measured in a five day spawning trial with an intact female. Spawning and fertility decreased one week following castration while nestbuilding was unaffected. Sham operated males showed normal spawning and fertility. Two weeks postope...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90281-5
更新日期：1977-09-01 00:00:00
abstract：:EEG sleep recordings were performed in rats after administration of CCK-8. Mildly food-deprived rats were given IP CCK-8 (8 and 16 micrograms/kg body weight) and behavioural as well as EEG changes were examined. With 16 micrograms/kg of CCK-8, there was a significant increase of slow wave sleep in the 30 min of record...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90242-v
更新日期：1990-12-01 00:00:00
abstract：:Appetite and eating are not only controlled by energy needs, but also by extrinsic factors that are not directly related to energy balance. Environmental signals that acquire motivational properties through associative learning-learned cues-can override homeostatic signals and stimulate eating in sated states, or inhi...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2011.04.059
更新日期：2011-09-26 00:00:00
abstract：:The electromotor behavior evoked by novel sensory stimuli in the electrogenic teleost fish Gnathonemus petersii was examined. Novelty responses (NRs) consisted of a transient accelerations of the rate of electric organ discharges following a change in sensory input. NRs were basically similar in nontreated and in immo...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00153-5
更新日期：1999-12-01 00:00:00
abstract：:In 1975, at the start of my junior year in college, I took a course on experimental methods in psychology from Dr. James C. Smith, when he was a Visiting Professor at Penn State University. That experience set me on the professional path of studying the neural bases of taste function and ingestion on which I remain to...
journal_title：Physiology & behavior
pub_type： 历史文章,杂志文章
doi：10.1016/j.physbeh.2015.04.026
更新日期：2015-12-01 00:00:00
abstract：:We investigated the relationship between perceived bitterness, food disgust sensitivity, and sex. Participants completed the 8-item Food Disgust Scale and a 6-n-propylthiouracil (PROP) taster test and were categorised as PROP non-tasters, medium-tasters, or supertasters. An analysis of variance of between-subject fact...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.02.036
更新日期：2019-05-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00207-8
更新日期：1998-12-01 00:00:00
abstract：:Behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses were investigated in farm mink (Mustela vison) selected for either confident or fearful behaviour for nine generations. Two groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given the serotonin (5-HT) 1A receptor agonist buspir...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00964-2
更新日期：2003-02-01 00:00:00
abstract：:Both subjective and objectively measured social status has been associated with multiple health outcomes, including weight status, but the mechanism for this relationship remains unclear. Experimental studies may help identify the causal mechanisms underlying low social standing as a pathway for obesity. Our objective...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2016.04.024
更新日期：2016-08-01 00:00:00
abstract：:A possible role of endogenous opioids in male copulatory behavior was examined in six experiments which studied the effects of opiate antagonists on the copulatory behavior of male hamsters (Mesocricetus auratus). In Experiment 1, the acute administration of naloxone hydrochloride (4 mg/kg, SC) ten minutes before test...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90048-x
更新日期：1986-01-01 00:00:00
abstract：:Rats secrete saliva in response to heat. In the present study, details of thermal salivation were investigated using the FOK rat in comparison with Sprague-Dawley (SD), Donryu, and ACI rats. The FOK rat is a strain inbred for genotypic heat adaptation and endures heat for long periods. Conscious rats of all four strai...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00541-6
更新日期：1998-03-01 00:00:00
abstract：:GPRC6A is an amino acid-sensing receptor highly expressed in the brain and in skeletal muscle. Although recent evidence suggests that genetically engineered GPRC6A receptor knockout (KO) mice are susceptible to develop subtle endocrine and metabolic disturbances, the underlying disruptions in energy metabolism are lar...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.05.015
更新日期：2013-06-13 00:00:00
abstract：:Our recent studies have shown that the difference in basal pain sensitivity to mechanical and thermal stimulation between Dark-Agouti (DA) rats and a novel congenic DA.1U rats is major histocompatibility complex (MHC) genes dependent. In the present study, we further used DA and DA.1U rats to investigate the role of M...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.04.009
更新日期：2015-08-01 00:00:00
abstract：:The alarmingly high rates of overweight and obesity pose a serious global health threat. Numerous factors can result in weight gain, one of which is excess consumption of caloric sweeteners. In an effort to aid weight loss efforts, many people have switched from caloric sweeteners to low calorie sweeteners, which prov...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2016.04.004
更新日期：2016-10-01 00:00:00
abstract：:Rats weighing about 450 g were provided with permanent catheters in the portal vein and the right auricle. This method allows blood sampling from the portal and peripheral circulation at the same moment in the nondisturbed unanesthetized rat. In the ad lib condition the portal glucose level was higher than that in the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90342-0
更新日期：1977-08-01 00:00:00
abstract：:It has been recognized for some time that a number of different neuropeptides exert powerful effects on food intake. During the last few years, the neurocircuitry within which these peptides operate has also begun to be elucidated. Peptidergic feeding-regulatory neurones are found both in the hypothalamus and the brai...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00611-4
更新日期：2001-11-01 00:00:00
abstract：:Locomotor activities in the goldfish Carassius auratus were recorded under light-dark (LD) and constant light regimens. Under LD 12:12, all goldfish adjusted to given LD cycles. Activity patterns were classified into three types: L-type activity during the photophase (83%), LD-type activity both during the photophase ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(96)00131-x
更新日期：1996-09-01 00:00:00
abstract：:Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.11.040
更新日期：2019-02-01 00:00:00
abstract：:After two hours of immobilization stress, C57BL/6 mice presented a significant reduction of spontaneous locomotion and a slight reduction of spontaneous climbing. The effect of stress on locomotor activity disappeared after ten daily sessions of immobilization while this chronic treatment increased the effect of stres...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90242-9
更新日期：1988-01-01 00:00:00
abstract：:Neophobia, or the fear of novel objects, is a behavior that is often found in wild animals. Neophobia appears to be related to the physiological stress response because individuals with higher glucocorticoid responses to stress often are more neophobic. The relationship between the heart rate response and novelty, how...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.04.014
更新日期：2016-07-01 00:00:00
abstract：:The effects of fluoxetine on food intake, body weight, and mood of obese individuals was examined in a 16-week inpatient/outpatient study. Six male and eight female obese volunteers began the study (four male and five females completed all phases of the study). They lived in a residential laboratory during three one-w...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(99)00020-7
更新日期：1999-07-01 00:00:00
abstract：:The food intakes of male and female rats (Harvard strain) adapted to cold (5 degrees C) starting at weaning were studied in the cold and during reacclimation to 25 degrees C. Following 24 hr food deprivation, the male rats regained the weight they had lost without making up for the food they had missed (increased food...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90377-8
更新日期：1982-07-01 00:00:00
abstract：:Young, specific-pathogen-free cats were fed purified diets containing different sources of fat. Food intake was depressed and cats lost weight when the diet contained either hydrogenated coconut oil (HCO) or medium-chain triglycerides (MCT). With an MCT preparation enriched in 8:0 (MCT8), cats would not eat after firs...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90311-7
更新日期：1985-09-01 00:00:00
abstract：:The objective of the study was to confirm the satiety/energy intake effect of a novel fat emulsion (Olibra) versus placebo in the short term. A randomized, double-blind, placebo-controlled, crossover design was used. 41 subjects participated in the study (n=21: junior-normal weight: age 23.7+/-2.8 years; BMI: 22.0+/-1...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.physbeh.2008.05.006
更新日期：2008-09-03 00:00:00
abstract：:Data are presented which demonstrate the task generality of pituitary-adrenal changes that accompany avoidance conditioning. In two experiments a conditioned aversion to milk was established by pairing it with lithium chloride (LiCl). In Experiment 1 conditioned pituitary-adrenal activation occurred when, in a conflic...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(76)90006-8
更新日期：1976-12-01 00:00:00
abstract：:Intermittent exposure to the same stressor can lead to a gradual decline in physiological, neuroendocrine and behavioral stress responses (habituation). We investigated possible habituation of cardiac autonomic responsiveness and susceptibility to cardiac arrhythmias in male rats exposed to either intermittent social ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00455-3
更新日期：2001-06-01 00:00:00
abstract：:Female mate choice is often investigated in terms of reproductive success in order to understand how male characteristics contribute to sexual attractiveness. Previous studies have found that females rats prefer mating with their first encounter rather than males visited subsequently, suggesting that the rewarding val...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.10.031
更新日期：2018-02-01 00:00:00
