Prognostic factors in the persistence of posttraumatic epilepsy after penetrating head injuries sustained in war.

Abstract:

OBJECT:The goal of this paper was to investigate the long-term outcome and the possible prognostic factors that might have influenced the persistence of posttraumatic epilepsy after penetrating head injuries sustained during the Iraq-Iran war (1980-1988). METHODS:In this retrospective study, the authors evaluated 189 patients who sustained penetrating head injury and suffered posttraumatic epilepsy during the Iraq-Iran war (mean 18.6 +/- 4.7 years after injury). The probabilities of persistent seizures (seizure occurrence in the past 2 years) in different periods after injury were estimated using the Kaplan-Meier method. The possible prognostic factors (patients and injury characteristics, clinical findings, and seizure characteristics) were studied using log-rank and Cox regression analysis. RESULTS:The probability of persistent seizures was 86.4% after 16 years and 74.7% after 21 years. In patients with < 3 pieces of shrapnel or no sphincter disturbances during seizure attacks, the probability of being seizure free after these 16 and 21 years was significantly higher. CONCLUSIONS:Early seizures, prophylactic antiepileptics drugs, and surgical intervention did not significantly affect long-term outcome in regard to persistence of seizures.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Eftekhar B,Sahraian MA,Nouralishahi B,Khaji A,Vahabi Z,Ghodsi M,Araghizadeh H,Soroush MR,Esmaeili SK,Masoumi M

doi

10.3171/2008.4.17519

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

319-26

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

110

pub_type

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