The larvicidal activity of cyclosporin A against Schistosoma mansoni in mice.

Abstract:

:Treatment of BALB/c or MF1 mice with cyclosporin A (CsA) around the time of infection with Schistosoma mansoni conferred almost complete protection. The migration kinetics of L-[75Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration were achieved by cercariae in control and drug-treated individuals. CsA arrested 87-94% of the worms in the skin and ultimately all of these died in this site. Few worms (7-14%) migrated from the skin to the lungs and none completed migration to the liver. Nevertheless, the autoradiograms revealed a limited degree of lateral cutaneous migration by the worms present in the skins of CsA-treated mice. Results of perfusion recovery experiments carried out during the course of infection reinforced the tracking data.

journal_name

Parasitology

journal_title

Parasitology

authors

Munro GH,Brannan LR,Chappell LH,Thomson AW,McLaren DJ

doi

10.1017/s0031182000060340

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

57-63

eissn

0031-1820

issn

1469-8161

journal_volume

102 Pt 1

pub_type

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