Abstract:
:Treatment of BALB/c or MF1 mice with cyclosporin A (CsA) around the time of infection with Schistosoma mansoni conferred almost complete protection. The migration kinetics of L-[75Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration were achieved by cercariae in control and drug-treated individuals. CsA arrested 87-94% of the worms in the skin and ultimately all of these died in this site. Few worms (7-14%) migrated from the skin to the lungs and none completed migration to the liver. Nevertheless, the autoradiograms revealed a limited degree of lateral cutaneous migration by the worms present in the skins of CsA-treated mice. Results of perfusion recovery experiments carried out during the course of infection reinforced the tracking data.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Munro GH,Brannan LR,Chappell LH,Thomson AW,McLaren DJdoi
10.1017/s0031182000060340subject
Has Abstractpub_date
1991-02-01 00:00:00pages
57-63eissn
0031-1820issn
1469-8161journal_volume
102 Pt 1pub_type
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