Abstract:
OBJECTIVE:Amorphous pharmaceuticals, a viable approach to enhancing bioavailability, must be stable against crystallization. An amorphous drug can be stabilized by dispersing it in a polymer matrix. To implement this approach, it is desirable to know the drug's solubility in the chosen polymer, which defines the maximal drug loading without risk of crystallization. Measuring the solubility of a crystalline drug in a polymer is difficult because the high viscosity of polymers makes achieving solubility equilibrium difficult. METHOD:Differential Scanning Calorimetry (DSC) was used to detect dissolution endpoints of solute/polymer mixtures prepared by cryomilling. This method was validated against other solubility-indicating methods. RESULTS:The solubilities of several small-molecule crystals in polymers were measured for the first time near the glass transition temperature, including D: -mannitol (beta polymorph) in PVP, indomethacin (gamma polymorph) in PVP/VA, and nifedipine (alpha polymorph) in PVP/VA. CONCLUSION:A DSC method was developed for measuring the solubility of crystalline drugs in polymers. Cryomilling the components prior to DSC analysis improved the uniformity of the mixtures and facilitated the determination of dissolution endpoints. This method has the potential of providing useful data for designing physically stable formulations of amorphous drugs.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Tao J,Sun Y,Zhang GG,Yu Ldoi
10.1007/s11095-008-9784-zsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
855-64issue
4eissn
0724-8741issn
1573-904Xjournal_volume
26pub_type
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1016283027139
更新日期:1995-02-01 00:00:00
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journal_title:Pharmaceutical research
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abstract::The effects of process and storage conditions of solid-state emulsions were studied. Oil-in-water emulsions may be prepared from solid state emulsions by adding an aqueous phase to the solid. Solid-state emulsions are prepared by processing an oil phase and an aqueous solution of matrix material via a solvent removal ...
journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2020-01-03 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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journal_title:Pharmaceutical research
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2018-06-25 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1012127829032
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To investigate how likely two extended release formulations are to be bioequivalent when they demonstrate f2 similarity. METHOD:Dissolution profiles were simulated using the Weibull model and varying model parameters around those of a reference profile. The f2 values were calculated for the comparisons of each...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-011-0377-x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:N-terminal site-specific mono-PEGylation of recombinant human epidermal growth factor (EGF) was accomplished using polyethyleneglycol (PEG) derivatives (Mw = 2000 and 5000) through a reactive terminal aldehyde group. METHODS:The site-specific PEG conjugation was conducted ata slightly acidic pH condition (pH 5...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1023402123119
更新日期:2003-05-01 00:00:00