Fulminant hepatitis induced by lamotrigine.

Abstract:

:Anticonvulsant hypersensitivity syndrome (AHS) is a potentially life-threatening adverse drug reaction presenting with fever, skin eruptions, and internal organ involvement. We describe a case of AHS with fulminant hepatitis that occurred two weeks after introduction of lamotrigine in a 40-year-old female patient with a recently diagnosed bipolar disorder, no pre-existent systemic organ involvement, and no other medication. Lamotrigine was introduced at a dosage of 25 mg daily and increased to 50 mg daily 12 days later. The patient had favorable evolution with cessation of lamotrigine and supportive treatment. This report suggests that AHS with fulminant hepatitis may occur idiosyncratically, independent of dosage, titration and comedication with other potentially hepatotoxic drugs.

journal_name

South Med J

journal_title

Southern medical journal

authors

Ouellet G,Tremblay L,Marleau D

doi

10.1097/SMJ.0b013e3181878b95

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

82-4

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

102

pub_type

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