当前位置： SCI文献检索 > JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS期刊下所有文献 > Identify protein-coding genes in the genomes of Aeropyrum pernix K1 and Chlorobium tepidum TLS.

Identify protein-coding genes in the genomes of Aeropyrum pernix K1 and Chlorobium tepidum TLS.

Abstract：

:The problem that how many protein-coding genes there are in the genome of Aeropyrum pernix K1 has confused many scientists since the sequencing in 1999. In this paper, the protein-coding genes in A. pernix K1 are identified from the original and current NITE annotation by using the Aper_ORFs method. Consequently, 702 of 704 experimentally validated genes are correctly predicted as coding, which means the sensitivity of the method is 702/704 approximately 99.7%. This sensitivity is one percent higher than that of the versatile bacterial gene-finding program, ZCURVE 1.0. The number of genes determined in this work is 1699. This number is very closely equal to that of the current NITE annotation, which is 1700. Therefore, the two independent predictions may end the ten-years-lasting controversy about gene number in this genome. Furthermore, the Aper_ORFs method is extended to identify protein-coding genes in the genome of Chlorobium tepidum TLS and about 98% of the function-known genes are correctly predicted as coding. In addition, 188 hypothetical ORFs are identified as non-coding in the genome. Mapping point analysis shows that these ORFs have different base frequency distribution with that of function-known genes, suggesting that most of them do not encode proteins. It's hoped the Aper_ORFs method will become a useful tool for gene annotation in newly sequenced bacterial and archaeal genomes, as long as the G+C content of which is similar with that of A. pernix.

journal_name

J Biomol Struct Dyn

journal_title

Journal of biomolecular structure & dynamics

authors

Guo FB,Lin Y

doi

10.1080/07391102.2009.10507256

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

413-20

issue

4

eissn

0739-1102

issn

1538-0254

pii

d=3035&c=4276&p=17019&do=detail

journal_volume

26

pub_type

杂志文章

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