Abstract:
:Incomplete and unbalanced multivariate data often arise in longitudinal studies due to missing or unequally-timed repeated measurements and/or the presence of time-varying covariates. A general approach to analysing such data is through maximum likelihood analysis using a linear model for the expected responses, and structural models for the within-subject covariances. Two important advantages of this approach are: (1) the generality of the model allows the analyst to consider a wider range of models than were previously possible using classical methods developed for balanced and complete data, and (2) maximum likelihood estimates obtained from incomplete data are often preferable to other estimates such as those obtained from complete cases from the standpoint of bias and efficiency. A variety of applications of the model are discussed, including univariate and multivariate analysis of incomplete repeated measures data, analysis of growth curves with missing data using random effects and time-series models, and applications to unbalanced longitudinal data.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Schluchter MDdoi
10.1002/sim.4780070132subject
Has Abstractpub_date
1988-01-01 00:00:00pages
317-24issue
1-2eissn
0277-6715issn
1097-0258journal_volume
7pub_type
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