Host and microbiologic factors associated with mortality in Taiwanese children with invasive pneumococcal diseases, 2001 to 2006.


:We concurrently evaluated host- and organism-related factors in determining the outcomes of 160 invasive pneumococcal diseases episodes in 158 Taiwanese children during 2001 and 2006. Most (138/160, 86.2%) episodes occurred at age less than 60 months, and an underlying condition was present in 35 (22.2%) cases. Common disease syndromes included complicated pneumonia (29.4%), uncomplicated pneumonia (29.4%), occult bacteremia (17.5%), and meningitis (14.4%). Mortality (13/160, 8.1%) was associated with age less than 24 months, underlying conditions, meningitis, cytopenia, intensive care, and penicillin MIC >or=2 microg/mL in univariate analysis. Pneumococcal serotypes, genotypes, origin of infections, and discordant therapy did not influence the outcome. Multivariate analysis determined the presence of underlying conditions (adjusted odds ratio [OR], 30.5; 95% confidence interval [CI], 4.8-193.1) and penicillin MIC >or=2 microg/mL (adjusted OR, 8.1; 95% CI, 1.4-47.3), which are the independent predictors for fatality. This finding highlighted the importance of immunization of disadvantaged children, targeting drug-resistant pneumococci.


Chen CJ,Lin CL,Chen YC,Wang CW,Chiu CH,Lin TY,Huang YC




Has Abstract


2009-02-01 00:00:00














  • Molecular diagnosis of Arcobacter and Campylobacter in diarrhoeal samples among Portuguese patients.

    abstract::The present study was conducted to investigate the prevalence and diversity of Arcobacter and Campylobacter spp. in 298 stool samples of patients with diarrhoea, collected from 22 Portuguese hospitals, between September and November 2012. Detection of Arcobacter and Campylobacter spp. was performed using molecular-bas...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究


    authors: Ferreira S,Júlio C,Queiroz JA,Domingues FC,Oleastro M

    更新日期:2014-03-01 00:00:00

  • Treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae in Mexico City.

    abstract::Since being recognized in 1976 and 1983, respectively, penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) and chromosomally mediated resistance (CMRNG) have attained a worldwide distribution. The high endemicity of both types of resistance in some regions precludes the continued routine use of procaine pe...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Calderón E,Conde CJ,de la Cruz R,Narcio L,Hirata C

    更新日期:1987-09-01 00:00:00

  • Comparative performance of peptide-, recombinant protein-, and viral lysate-based enzyme immunosorbent assays for the detection of HIV-1 antibodies.

    abstract::The performance of peptide-, recombinant protein-, and whole virus lysate-based enzyme immunosorbent assays (EIAs) for the detection of antibodies to the human immunodeficiency virus type 1 (HIV-1) was compared on a panel of 245 routine samples, a panel of low-positive samples, four seroconversion panels, and serial d...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Griffith BP,Chacko TM

    更新日期:1993-05-01 00:00:00

  • Evaluation of rapid culture centrifugation method for adenovirus detection in stools.

    abstract::Routine laboratory testing for adenovirus (Adv) requires a procedure that is rapid and reliable, especially for samples from children and immunosuppressed patients, when diarrhea may signal the onset of severe gastrointestinal disorders. An improved culture technique for Adv isolation, using centrifugation step of 24-...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Durepaire N,Ranger-Rogez S,Denis F

    更新日期:1996-01-01 00:00:00

  • Clinical evaluation of a dried commercially prepared microdilution panel for antifungal susceptibility testing of five antifungal agents against Candida spp. and Cryptococcus neoformans.

    abstract::A commercially prepared dried-broth microdilution panel (Sensititre, TREK Diagnostic Systems, Cleveland, OH) was compared with a reference frozen-broth microdilution panel for antifungal susceptibility testing of 728 clinical isolates of Candida spp. and 98 clinical isolates of Cryptococcus neoformans. The antifungal ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Pfaller MA,Boyken L,Hollis RJ,Messer SA,Tendolkar S,Diekema DJ

    更新日期:2004-10-01 00:00:00

  • Antimicrobial activity of cefepime tested against Bush group I beta-lactamase-producing strains resistant to ceftazidime. A multilaboratory national and international clinical isolate study.

    abstract::The potency of cefepime, a parenteral aminothiazolyl methoxyimino cephalosporin, was assessed against 256 ceftazidime-resistant Gram-negative bacilli from five medical centers in the United States. In addition, cefepime activity was compared with that of ciprofloxacin and imipenem against 506 ceftazidime-resistant Gra...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究


    authors: Jones RN,Marshall SA

    更新日期:1994-05-01 00:00:00

  • In vitro activity of recombinant lysostaphin-antibiotic combinations toward methicillin-resistant Staphylococcus aureus.

    abstract::In vitro bactericidal experiments were performed with combinations of recombinant lysostaphin and various antibiotics against five strains of Staphylococcus aureus, including clinical isolates of methicillin-resistant S. aureus (MRSA). Sublethal concentrations of lysostaphin combined with beta-lactam antibiotics (incl...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Polak J,Della Latta P,Blackburn P

    更新日期:1993-11-01 00:00:00

  • Characterization of Trypanosoma cruzi isolated from humans, vectors, and animal reservoirs following an outbreak of acute human Chagas disease in Santa Catarina State, Brazil.

    abstract::During March 2005, 24 cases of acute human Chagas disease were detected in Santa Catarina State, southern Brazil, all of them related to the ingestion of Trypanosoma cruzi-contaminated sugar cane juice. Following field studies allowed the isolation of 13 T. cruzi strains from humans, opossums (Didelphis aurita and Did...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Steindel M,Kramer Pacheco L,Scholl D,Soares M,de Moraes MH,Eger I,Kosmann C,Sincero TC,Stoco PH,Murta SM,de Carvalho-Pinto CJ,Grisard EC

    更新日期:2008-01-01 00:00:00

  • Cephalothin is not a reliable surrogate marker for oral cephalosporins in susceptibility testing of Enterobacteriaceae causing urinary tract infection.

    abstract::Vitek® 2 (bioMérieux) is a widely used commercial antimicrobial susceptibility test (AST) system. AST-N244 card includes cephalothin as first-generation cephalosporin. We compared the cephalothin susceptibility results obtained with Vitek® 2 AST-N244 to those obtained by broth microdilution (BMD) and disk diffusion (D...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: López IA,Montes JC,Álvarez MJ,Mazarrasa CF,Martínez-Martínez L

    更新日期:2016-12-01 00:00:00

  • Prediction of community-onset bacteremia among febrile adults visiting an emergency department: rigor matters.

    abstract:OBJECTIVES:Bacteremia is a severe bacterial infection with significant mortality and morbidity. Clinical parameters that reliably predict the presence of community-onset bacteremia are less elucidated. METHODS:During 96 randomly selected days between August 2006 and July 2007, a prospective study was conducted to anal...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Lee CC,Wu CJ,Chi CH,Lee NY,Chen PL,Lee HC,Chang CM,Ko NY,Ko WC

    更新日期:2012-06-01 00:00:00

  • Molecular epidemiology of KPC-2-producing Enterobacteriaceae (non-Klebsiella pneumoniae) isolated from Brazil.

    abstract::In Brazil, since 2009, there has been an ever increasing widespread of the bla(KPC-2) gene, mainly in Klebsiella pneumoniae. This study aims to assess the molecular epidemiology and genetic background of this gene in Enterobacteriaceae (non-K. pneumoniae) species from 9 Brazilian states between 2009 and 2011. Three hu...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Tavares CP,Pereira PS,Marques Ede A,Faria C Jr,de Souza Mda P,de Almeida R,Alves Cde F,Asensi MD,Carvalho-Assef AP

    更新日期:2015-08-01 00:00:00

  • Impact of immune status on the clinical characteristics and treatment outcomes of nocardiosis.

    abstract::Nocardiosis occurs in both immunocompromised and immunocompetent patients. We aimed to assess how its characteristics differ depending on patients' immune status. Of a total of 54 patients with culture-proven nocardiosis diagnosed over 13 years, 18 (33%) were immunocompetent. Half of immunocompetent patients had chron...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Kim YK,Sung H,Jung J,Yu SN,Lee JY,Kim SH,Choi SH,Kim YS,Woo JH,Lee SO,Chong YP

    更新日期:2016-08-01 00:00:00

  • The clinical significance of isolation of two different organisms from the urine of patients with an indwelling catheter.

    abstract:BACKGROUND:We evaluated the clinical significance of urine cultures from patients with an indwelling urinary catheter (UC) from which 2 different pathogens were isolated. METHODS:Urine cultures from patients with a UC from which 2 different organisms were isolated were randomly divided into a control group (culture re...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Wiener-Well Y,Gofman I,Assous MV,Freier-Dror Y,Yinnon AM,Lachish T

    更新日期:2013-05-01 00:00:00

  • Gatifloxacin in community-based treatment of acute respiratory tract infections in the elderly.

    abstract::The elderly are at increased risk for respiratory tract infections. To evaluate the safety and efficacy of gatifloxacin in adults of any age with community-acquired respiratory tract infections, this open-label, multicenter, noncomparative study in community-based practices enrolled male and female outpatients at leas...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Nicholson SC,High KP,Gothelf S,Webb CD

    更新日期:2002-09-01 00:00:00

  • Evaluation of the Abbott ARCHITECT Toxo IgM assay.

    abstract::Development of the ARCHITECT Toxo IgM assay has been done to assist the clinician in acute Toxoplasma gondii infection detection, especially in pregnant women. Its use, in conjunction with ARCHITECT Toxo IgG and Toxo Avidity assays, will provide an array of assays particularly useful in the monitoring of pregnant fema...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Sickinger E,Braun HB,Praast G,Stieler M,Gundlach C,Birkenbach C,Prostko J,Palafox MA,Frias E,Hsu S,Matias M,Pucci D,Hausmann M,Sagel U,Smith D

    更新日期:2009-07-01 00:00:00

  • A highly sensitive 1-tube nested real-time RT-PCR assay using LNA-modified primers for detection of respiratory syncytial virus.

    abstract::Respiratory syncytial virus (RSV) causes serious respiratory tract infection worldwide. The relatively low RSV load makes it difficult to detect in frail, elderly, and severely immune-compromised patients. In the present study, we developed a locked nucleic acid--based 1-tube nested real-time RT-PCR (OTNRT-PCR) assay ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Zhao L,Wang J,Li GX,Qiu FZ,Chen C,Zhao MC,Wang L,Duan SX,Feng ZS,Ma XJ

    更新日期:2019-02-01 00:00:00

  • Mycetoma of the scalp due to Microsporum canis: hystopathologic, mycologic, and immunogenetic features in a 6-year-old girl.

    abstract::Dermatophytic mycetoma is an extremely rare subcutaneous mycosis. Here, we report the case of a 6-year-old girl with clinical, histologic, and mycologic findings consistent with a mycetoma of the scalp caused by Microsporum canis. To our knowledge, this is the first report showing the immunologic and immunogenetic fea...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Chiapello LS,Dib MD,Nuncira CT,Nardelli L,Vullo C,Collino C,Abiega C,Cortes PR,Spesso MF,Masih DT

    更新日期:2011-05-01 00:00:00

  • Helicobacter pylori growth stimulation by adrenaline detected by two methods.

    abstract::Our aim was to assess growth effects of adrenaline on 32 Helicobacter pylori strains on 2.5% blood agar. By agar-well diffusion and disk diffusion methods, concentration-dependent growth stimulation occurred in ≤50.0% and 36.8% of the strains, respectively. Growth inhibition was less frequent. Most strains were adrena...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Boyanova L,Markovska R,Mitov I

    更新日期:2019-01-01 00:00:00

  • Bipolaris oryzae, a novel fungal opportunist causing keratitis.

    abstract::We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation factor 1α (TEF1) gene, and partial glyceraldehyde-3-phosphate dehydrogenase (GPDH) gene, and the species ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Wang L,Al-Hatmi AM,Lai X,Peng L,Yang C,Lai H,Li J,Meis JF,de Hoog GS,Zhuo C,Chen M

    更新日期:2016-05-01 00:00:00

  • Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections.

    abstract::Clostridium difficile infections (CDI) is a leading cause of nosocomial infections worldwide. The changes in the epidemiology of CDI during the past years, including the appearance of new epidemic strains of C. difficile that cause CDI episodes with increased severity, have led to the development of molecular methods ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Hernández-Rocha C,Barra-Carrasco J,Álvarez-Lobos M,Paredes-Sabja D,Guzmán-Durán AM

    更新日期:2013-04-01 00:00:00

  • Rapid identification of fungal pathogens in BacT/ALERT, BACTEC, and BBL MGIT media using polymerase chain reaction and DNA sequencing of the internal transcribed spacer regions.

    abstract::We report a direct polymerase chain reaction/sequence (d-PCRS)-based method for the rapid identification of clinically significant fungi from 5 different types of commercial broth enrichment media inoculated with clinical specimens. Media including BacT/ALERT FA (BioMérieux, Marcy l'Etoile, France) (n = 87), BACTEC Pl...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Pryce TM,Palladino S,Price DM,Gardam DJ,Campbell PB,Christiansen KJ,Murray RJ

    更新日期:2006-04-01 00:00:00

  • Metabolic interactions of ciprofloxacin.

    abstract::The mechanism and clinical relevance of the inhibitory effect of ciprofloxacin on the metabolism of selected drugs were studied in patients with bacterial infections. In study A, antipyrine tests were carried out in two groups of patients taking 1000 mg (group 1) and 250 mg (group 2) of oral ciprofloxacin for 7-10 day...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Ludwig E,Graber H,Székely E,Csiba A

    更新日期:1990-03-01 00:00:00

  • Comparison of five different susceptibility test methods for detecting antimicrobial agent resistance among Haemophilus influenzae isolates.

    abstract::The detection of antimicrobial agent resistance among ninety-eight Haemophilus influenzae isolates was assessed by six different antibiotic test methods: agar dilution on Mueller-Hinton agar supplemented with 5% lysed horse blood (MH-LHB), E-test using both Haemophilus test medium (HTM) agar and chocolate Mueller-Hint...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Giger O,Mortensen JE,Clark RB,Evangelista A

    更新日期:1996-03-01 00:00:00

  • Evaluation of a commercial latex agglutination method for toxoplasmosis.

    abstract::A commercial latex agglutination test for detecting immunoglobulin G antibody to Toxoplasma gondii, the Syn-Kit Toxotest MT, was evaluated in two laboratories against the Sabin-Feldman dye test, the indirect immunofluorescence test, and FIAX. The Toxotest MT was found easy to perform and required no special equipment ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Walls KW,Remington JS

    更新日期:1983-12-01 00:00:00

  • Major methodology-dependent discordant susceptibility results for Bacteroides fragilis group isolates but not other anaerobes.

    abstract::Two standardized susceptibility test methods, a broth microdilution (BMD) and agar dilution (AD) method were performed on a total of 441 clinical isolates of anaerobes with ceftizoxime, cefotaxime, ceftriaxone, cefoxitin, piperacillin, and metronidazole. Against the 339 strains of the Bacteroides fragilis group BMD mi...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Aldridge KE,Schiro DD

    更新日期:1994-11-01 00:00:00

  • Evaluation of alternative disk diffusion methods for detecting mecA-mediated oxacillin resistance in an international collection of staphylococci: validation report from the SENTRY Antimicrobial Surveillance Program.

    abstract::To validate the current National Committee for Clinical Laboratory Standards recommendations of the cefoxitin disk as a preferred surrogate marker to detect oxacillin resistance in staphylococcal isolates, 304 staphylococcal isolates originating from 49 sites in 16 countries in the SENTRY Antimicrobial Surveillance Pr...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Pottumarthy S,Fritsche TR,Jones RN

    更新日期:2005-01-01 00:00:00

  • In vitro antimicrobial activity of GAR-936 tested against antibiotic-resistant gram-positive blood stream infection isolates and strains producing extended-spectrum beta-lactamases.

    abstract::GAR-936, a new, semisynthetic glycylcycline, has shown good antibacterial activity against a wide range of clinically important Gram-positive and -negative aerobic bacteria including Streptococcus pneumoniae, Hemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, most Enterobacteriaceae, Staphylococcus a...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Biedenbach DJ,Beach ML,Jones RN

    更新日期:2001-08-01 00:00:00

  • Development of a 1-step cell-based assay for cost-effective screening of antiviral drugs for vaccinia virus.

    abstract::We report a 1-step assay to screen antiviral substances combining the simultaneous application of cells, virus sample, and drug to 96-well plates. The results were obtained within 26 h when vaccinia virus plaques were counted or virus-induced cytopathic effect was measured. This fast cost-effective procedure may be us...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Jesus DM,Santos ES,Schnellrath LC,Damaso CR

    更新日期:2009-07-01 00:00:00

  • Distribution of AdeABC efflux system genes in genotypically diverse strains of clinical Acinetobacter baumannii.

    abstract::Acinetobacter baumannii has emerged as a highly problematic hospital-associated pathogen. Different mechanisms contribute to the formation of multidrug resistance in A. baumannii, including the AdeABC efflux system. Distribution of the structural and regulatory genes encoding the AdeABC efflux system among genetically...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Wieczorek P,Sacha P,Czaban S,Hauschild T,Ojdana D,Kowalczuk O,Milewski R,Poniatowski B,Nikliński J,Tryniszewska E

    更新日期:2013-10-01 00:00:00

  • Identification by 16S ribosomal RNA gene sequencing of an Enterobacteriaceae species with ambiguous biochemical profile from a renal transplant recipient.

    abstract::Traditional ways of identification of bacteria by phenotypic characteristics cannot be used for non-cultivable organisms and organisms with unusual biochemical profiles. In this study, an Enterobacteriaceae was isolated in pure growth from the mid-stream urine of a 67-year old renal transplant recipient with urinary t...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章


    authors: Woo PC,Cheung EY,Leung K,Yuen K

    更新日期:2001-02-01 00:00:00