Viewing a humorous film decreases IgE production by seminal B cells from patients with atopic eczema.

Abstract:

OBJECTIVE:Sperms induced IgE production by seminal B cells from patients with atopic eczema via interaction of B cells with galectin-3 on sperms. We studied the effect of viewing a humorous film on IgE production by seminal B cells cultured with sperms. METHODS:Twenty-four male patients with atopic eczema viewed a humorous film (Modern Times, featuring Charlie Chaplin). Just before and immediately after viewing, semen was collected, and seminal B cells and sperms were purified. Seminal B cells were cultured with sperms and IgE production was measured, while expression of galectin-3 on sperms was assessed. RESULTS:After viewing the humorous film, IgE production by B cells cultured with sperms was significantly decreased. Moreover, expression of galectin-3 on sperms was reduced. CONCLUSION:Viewing a humorous film reduced galectin-3 expression on sperms, which in turn decreased IgE production by seminal B cells cultured with sperms. These results indicate that viewing a humorous film may be helpful for the study and treatment of local IgE production and allergy in the reproductive tract.

journal_name

J Psychosom Res

authors

Kimata H

doi

10.1016/j.jpsychores.2008.06.006

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

173-5

issue

2

eissn

0022-3999

issn

1879-1360

pii

S0022-3999(08)00290-0

journal_volume

66

pub_type

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