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Mediterranean diet and antihypertensive drug use: a randomized controlled trial.

Abstract：

OBJECTIVE:To examine in older individuals at high cardiovascular risk whether following a Mediterranean diet decreased the necessity of antihypertensive drugs and modulated their associated cardiovascular risk. METHODS:In the PREvención con DIeta MEDiterránea study, we assessed whether volunteers randomly allocated to an intervention with a Mediterranean diet enriched with extra-virgin olive oil or nuts (relative to a low-fat control diet) disclosed differences in the risk of: initiating antihypertensive medication in nonusers at baseline (n = 2188); and escalating therapy in participants using one, two, or three drugs at baseline (n = 2361, n = 1579, and n = 554, respectively). We also assessed whether allocation to Mediterranean diet modified the association between antihypertensive drug use and incident cardiovascular events. RESULTS:Participants allocated to Mediterranean diet interventions were associated with lower risk of initiating antihypertensive therapy [5-year incidence rates: 47.1% in the control diet, 43.0% in MedDiets; hazard ratio = 0.84, 95% CI (0.74--0.97), in a model adjusted for age, sex, and recruitment site]. Volunteers using two drugs at baseline in the Mediterranean diet intervention enriched with extra-virgin olive oil decreased their risk of therapy escalation [5-year incidence rates: 22.9% in the control diet, 20.1% in the MedDiet; hazard ratio = 0.77, 95% CI (0.60--0.99)]. Allocation to Mediterranean diet interventions attenuated the association between antihypertensive therapy at baseline and incidence of major adverse cardiovascular events (P interaction = 0.003). CONCLUSION:In an older population at high cardiovascular risk, following a Mediterranean diet reduced the risk of initiating or escalating antihypertensive medication and attenuated cardiovascular risk in antihypertensive drug users.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Ribó-Coll M,Lassale C,Sacanella E,Ros E,Toledo E,Sorlí JV,Babio N,Lapetra J,Gómez-Gracia E,Alonso-Gómez ÁM,Fiol M,Serra-Majem L,Pinto X,Castañer O,Díez-Espino J,González JI,Becerra-Tomás N,Cofán M,Díaz-López A,Estru

doi

10.1097/HJH.0000000000002765

subject

Has Abstract

pub_date

2021-01-25 00:00:00

eissn

0263-6352

issn

1473-5598

pii

00004872-900000000-96734

pub_type

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Mediterranean diet and antihypertensive drug use: a randomized controlled trial.