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OUTCOMES AFTER VASCULAR SURGERY PROCEDURES IN PATIENTS WITH COVID-19 INFECTION: A NATIONAL MULTICENTRE COHORT STUDY (COVID-VAS).

Abstract：

OBJECTIVES:To analyze the outcome of vascular procedures performed in patients with COVID-19 infection during the 2020 pandemic. METHODS:This is a multicenter, prospective observational cohort study. We analyzed data from 75 patients with COVID-19 infection undergoing vascular surgery procedures in 17 hospitals across Spain and Andorra between March and May 2020. The primary end point was 30-day mortality. Clinical Trials registry number NCT04333693. RESULTS:The mean age was 70.9 (45-94) and 58 (77.0%) patients were male. Around 70.7% had postoperative complications, 36.0% of patients experienced respiratory failure, 22.7% acute renal failure, and 22.7% acute respiratory distress syndrome (ARDS). All-cause 30-days mortality rate was 37.3%. Multivariate analysis identified age >65 years (P = 0.009), American Society of Anesthesiologists (ASA) classification IV (P = 0.004), preoperative lymphocyte count <0.6 (×109/L) (P = 0.001) and lactate dehydrogenase (LDH) >500 (UI/L) (P = 0.004), need for invasive ventilation (P = 0.043), postoperative acute renal failure (P = 0.001), ARDS (P = 0.003) and major amputation (P = 0.009) as independent variables associated with mortality. Preoperative coma (P = 0.001), quick Sepsis Related Organ Failure Assessment (qSOFA) score ≥2 (P = 0.043), lymphocytes <0.6 (×109/L) (P = 0.019) leucocytes >11.5 (×109/L) (P = 0.007) and serum ferritin >1800 mg/dL (P = 0.004), bilateral lung infiltrates on thorax computed tomography (P = 0.025), and postoperative acute renal failure (P = 0.009) increased the risk of postoperative ARDS. qSOFA score ≥2 was the only risk factor associated with postoperative sepsis (P = 0.041). CONCLUSIONS:Patients with COVID-19 infection undergoing vascular surgery procedures showed poor 30-days survival. Age >65 years, preoperative lymphocytes <0.6 (x109/L) and LDH >500 (UI/L), and postoperative acute renal failure, ARDS and need for major amputation were identified as prognostic factors of 30-days mortality.

journal_name

Ann Vasc Surg

journal_title

Annals of vascular surgery

authors

San Norberto EM,De Haro J,Peña R,Riera L,Fernández-Caballero D,Sesma A,Rodríguez-Cabeza P,Ballesteros M,Gómez-Jabalera E,Taneva GT,Aparicio C,Moradillo N,Soguero I,Badrenas AM,Lara R,Torres A,Sala VA,Vaquero C,COVID-V

doi

10.1016/j.avsg.2021.01.054

subject

Has Abstract

pub_date

2021-01-22 00:00:00

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(21)00054-6

pub_type

杂志文章

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OUTCOMES AFTER VASCULAR SURGERY PROCEDURES IN PATIENTS WITH COVID-19 INFECTION: A NATIONAL MULTICENTRE COHORT STUDY (COVID-VAS).