Association of longitudinal changes in NT-proBNP with changes in Left Atrial Volume and Function: MESA.

Abstract:

BACKGROUND:The mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multi-ethnic population. METHODS:From the prospective cohort study, the Multi-Ethnic Study of Atherosclerosis, our analysis included 1838 participants who underwent cardiac magnetic resonance imaging at the baseline and 10-year examinations, had NT-proBNP levels available at both time points, and did not develop heart failure, myocardial infarction and/or atrial fibrillation. Multivariable linear regression was used to analyze the association between NT-proBNP level (log-transformed) at the two time points and change in LA volumes, LA emptying fractions (total, active and passive) and LA longitudinal strain. Log NT-proBNP was categorized into Low-Low (N=681), Low-High (N=238), High-Low (N=237), and High-High (N=682) based on the median value at both time points. RESULTS:With the Low-Low group as the reference group, the High-High group experienced a greater increase in LA maximum and minimum indexed volumes: 3.1 ml/m 2 (95% confidence interval (CI) 1.98, 4.20) and 2.7 ml/m 2 (1.89, 3.51) respectively. The High-High group also experienced a greater decrease in LA total, passive, active emptying fraction and longitudinal strain: -3.3% (-4.46, -2.11), -0.9% (-1.80, -0.02), -4.2% (-5.55, -2.76), and -2.3% (-3.80, -0.72) respectively. The Low-High group had similar associations, but the effect-sizes were not as high. CONCLUSIONS:Adverse LA remodeling over 10 years of follow-up strongly correlates with prolonged elevated levels of intra-cardiac stress, as assessed by NT-proBNP levels.

journal_name

Am J Hypertens

authors

Varadarajan V,Ambale-Venkatesh B,Hong SY,Habibi M,Ashikaga H,Wu CO,Chen LY,Heckbert SR,Bluemke DA,Lima JAC

doi

10.1093/ajh/hpab018

subject

Has Abstract

pub_date

2021-01-25 00:00:00

eissn

0895-7061

issn

1941-7225

pii

6118660

pub_type

杂志文章
  • Changes of plasma endothelin and growth factor levels, and of left ventricular mass, after chronic AT1-receptor blockade in human hypertension.

    abstract::The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00027-2

    authors: Cottone S,Vadalà A,Vella MC,Nardi E,Mulé G,Contorno A,Riccobene R,Cerasola G

    更新日期:1998-05-01 00:00:00

  • G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study.

    abstract:BACKGROUND:The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2007.06.001

    authors: Bhuiyan AR,Chen W,Srinivasan SR,Rice J,Mock N,Tang R,Bond MG,Boerwinkle E,Berenson GS

    更新日期:2007-10-01 00:00:00

  • Prevalence and Determinants of Hypertension in India Based on the 2017 ACC/AHA Guideline: Evidence from the India National Family Health Survey.

    abstract:OBJECTIVE:To estimate the prevalence and determinants of hypertension in India based on a new definition by the 2017 American College of Cardiology/American Heart Association (2017 ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults, and compare prevalence estima...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpz181

    authors: Abariga SA,Khachan H,Al Kibria GM

    更新日期:2020-03-13 00:00:00

  • Characterization of a Na+/K+-ATPase inhibitor from human plasma: preliminary data.

    abstract::The role of an endogenous sodium pump inhibitor in the pathogenesis of hypertension has been reported in several papers. Unfortunately, because of the unknown structure and lack of biochemical characterization, some discrepancies have arisen. In this study we report a method to obtain extracts from human plasma that a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.56s

    authors: Boschi S,Munarini A,Borghi C,Strocchi E,Costa FV,Mussi A,Ettore A

    更新日期:1988-07-01 00:00:00

  • Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.

    abstract:BACKGROUND:We reported that insulin modestly stimulates NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells (VSMC) and synergistically stimulates enzyme activity with angiotensin II (Ang II), leading to synergistic stimulation of VSMC migration. The aim of this study was to determine the mechanism of ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.11.017

    authors: Yang M,Kahn AM

    更新日期:2006-06-01 00:00:00

  • Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.

    abstract::In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.6.505

    authors: Khaw KT,Barrett-Connor E

    更新日期:1990-06-01 00:00:00

  • Adiposity and blood pressure in South Asian children and adolescents in Karachi.

    abstract:BACKGROUND:The association of adiposity during childhood with future risk of elevated blood pressure (BP) in South Asian children is not known. We aimed to investigate the relationship between waist circumference (WC) and body mass index (BMI) with BP over a 2-year period, independent of the baseline BP. METHODS:We an...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ajh.2011.67

    authors: Almas A,Jafar TH

    更新日期:2011-08-01 00:00:00

  • Effect of dietary sodium on insulin sensitivity in older, obese, sedentary hypertensives.

    abstract::Increased dietary sodium intake has been associated with an increase in blood pressure as well as a decrease in insulin-mediated glucose disposal in young healthy adults. The purpose of this study was to determine whether dietary sodium intake is associated with changes in oral glucose tolerance, insulin sensitivity, ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(97)00159-3

    authors: Dengel DR,Mayuga RS,Kairis GM,Goldberg AP,Weir MR

    更新日期:1997-09-01 00:00:00

  • Racial/ethnic differences in hypertension prevalence, treatment, and control for outpatients in northern California 2010-2012.

    abstract:BACKGROUND:Hypertension (HTN) is a known major cardiovascular disease risk factor, but prevalence, treatment, and control of HTN among rapidly growing minority groups such as Asian Americans and Hispanics are unknown largely due to either underrepresentation in epidemiologic studies or aggregation of Asian American sub...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajh/hpu189

    authors: Zhao B,Jose PO,Pu J,Chung S,Ancheta IB,Fortmann SP,Palaniappan LP

    更新日期:2015-05-01 00:00:00

  • Methods and devices for measuring arterial compliance in humans.

    abstract::This review analyses methods and devices used worldwide to evaluate the arterial stiffness. Three main methodologies are based upon analysis of pulse transit time, of wave contour of the arterial pulse, and of direct measurement of arterial geometry and pressure, corresponding to regional, systemic and local determina...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(02)02962-x

    authors: Pannier BM,Avolio AP,Hoeks A,Mancia G,Takazawa K

    更新日期:2002-08-01 00:00:00

  • Hypertension management in 2002: where have we been? where might we be going?

    abstract::The term "blood pressure" was coined almost 300 years ago by the man who first measured it, the Reverend Stephen Hales of England. However, our understanding of the pathogenesis and consequences of hypertension, as well as the available treatments for it, have remained greatly limited and inadequate until only the pas...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(02)03004-2

    authors: Hansson L

    更新日期:2002-10-01 00:00:00

  • Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.04.002

    authors: Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

    更新日期:2006-11-01 00:00:00

  • Subtypes of hypertension and risk of stroke in rural Chinese adults.

    abstract:BACKGROUND:Hypertension is a definitive risk factor for stroke. We examined the associations between hypertension subtypes and stroke incidence in rural Chinese adults. METHODS:We conducted a prospective study in a sample of 38,949 rural Chinese adults aged ≥35 years and free from stroke at baseline. The subtypes of h...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt197

    authors: Sun Z,Han X,Zheng L,Zhang X,Li J,Hu D,Sun Y

    更新日期:2014-02-01 00:00:00

  • New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

    abstract:BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...

    journal_title:American journal of hypertension

    pub_type:

    doi:10.1093/ajh/hpz125

    authors: Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

    更新日期:2019-11-15 00:00:00

  • Specific genetic influences on nighttime blood pressure.

    abstract:OBJECTIVES:Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1093/ajh/hpu162

    authors: Xu X,Su S,Treiber FA,Vlietinck R,Fagard R,Derom C,Gielen M,Loos RJ,Snieder H,Wang X

    更新日期:2015-04-01 00:00:00

  • Masked hypertension in the elderly: cross-sectional analysis of a population-based sample.

    abstract:BACKGROUND:Masked hypertension (MHT), defined as normal blood pressure (BP) at office associated with high BP at home, has been shown to be associated with an increased risk of vascular events. However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.23

    authors: Cacciolati C,Hanon O,Alpérovitch A,Dufouil C,Tzourio C

    更新日期:2011-06-01 00:00:00

  • Estimated healthcare savings associated with adequate dairy food intake.

    abstract::Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/j.amjhyper.2003.08.008

    authors: McCarron DA,Heaney RP

    更新日期:2004-01-01 00:00:00

  • Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure.

    abstract:BACKGROUND:We previously showed that the infusion of tumor necrosis factor alpha (TNF-alpha) induces hypertension and vascular dysfunction in late pregnant but not virgin rats. In the present study, we tested the hypothesis that levels of ovarian hormones to mimic pregnancy are required for TNF-alpha-induced changes in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2007.07.002

    authors: LaMarca BD,Chandler DL,Grubbs L,Bain J,McLemore GR Jr,Granger JP,Ryan MJ

    更新日期:2007-11-01 00:00:00

  • Ambulatory blood pressure after acute exercise in older men with essential hypertension.

    abstract::We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(99)00141-7

    authors: Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

    更新日期:2000-01-01 00:00:00

  • Antagonism of the renin-angiotensin system can counteract cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in the normal heart.

    abstract:BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.04.023

    authors: Siddiqui AJ,Mansson-Broberg A,Gustafsson T,Grinnemo KH,Dellgren G,Hao X,Fischer H,Sylvén C

    更新日期:2005-10-01 00:00:00

  • Hyperinsulinemia and insulin resistance are associated with preeclampsia in African-Americans.

    abstract::There is evidence that hyperinsulinemia and insulin resistance play a role in the development of hypertension. Accordingly, in our ongoing longitudinal study of pregnancy-induced hypertension, we have measured fasting levels of insulin and glucose at 18 to 25 weeks gestation in 140 nulliparous African-American women f...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(94)00166-9

    authors: Sowers JR,Saleh AA,Sokol RJ

    更新日期:1995-01-01 00:00:00

  • Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity.

    abstract::Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.10.754

    authors: Wolpert HA,Steen SN,Istfan NW,Simonson DC

    更新日期:1992-10-01 00:00:00

  • A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study.

    abstract:OBJECTIVE:The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS:This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu249

    authors: Eguchi K,Hoshide S,Komori T,Nagasaka S,Kario K

    更新日期:2015-08-01 00:00:00

  • Effect of hypoxic exercise on atrial natriuretic factor and aldosterone regulation.

    abstract::To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.4.341

    authors: Lawrence DL,Shenker Y

    更新日期:1991-04-01 00:00:00

  • Effects of a human-derived sodium transport inhibitor on in vitro vascular reactivity.

    abstract::Concentrations of sodium-transport inhibitors (STI) which block the sodium-potassium-ATPase pump are increased in the plasma and urine of volume-expanded and low-renin hypertensive humans and animals. To evaluate the physiologic relevance of STI to blood-pressure-raising mechanisms, we have examined the in vitro prope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.10.754

    authors: Weber MA,Weiler E,Gonick HC,Prins BA,Purdy RE

    更新日期:1989-10-01 00:00:00

  • The effect of sodium supplementation on glucose tolerance and insulin concentrations in patients with hypertension and diabetes mellitus.

    abstract::Severe short-term sodium restriction or extreme sodium loading may alter glucose tolerance and insulin resistance in patients with hypertension, but it is unclear whether variations in sodium intake within the clinically observed range affect glucose tolerance. To examine this issue, 21 patients with primary hypertens...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(01)01310-3

    authors: Ames RP

    更新日期:2001-07-01 00:00:00

  • Worldwide trends and shortcomings in the treatment of hypertension.

    abstract::Despite advances in the availability and quality of antihypertensive medications and the institution of national programs to educate people about the seriousness of hypertension, much remains to be done. The percentages of people who are aware of their disease, are being treated for it, and are achieving adequate cont...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(00)00273-9

    authors: Julius S

    更新日期:2000-05-01 00:00:00

  • Short-term antihypertensive medication does not exacerbate sleep-disordered breathing in newly diagnosed hypertensive patients.

    abstract::It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a dou...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(96)00507-9

    authors: Bartel PR,Loock M,Becker P,Robinson E,van der Meyden C,Rossouw S

    更新日期:1997-06-01 00:00:00

  • Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.

    abstract:BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu059

    authors: Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

    更新日期:2014-11-01 00:00:00

  • Aerobic exercise training fails to reduce blood pressure in nondipper-type hypertension.

    abstract::To assess whether aerobic exercise training is an effective and an alternative method to control blood pressure (BP) in hypertension, 32 uncomplicated, never treated patients suffering from mild-to-moderate essential arterial hypertension (EAH) were included in an aerobic exercise training program using a regular stan...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00265-4

    authors: Nami R,Mondillo S,Agricola E,Lenti S,Ferro G,Nami N,Tarantino M,Glauco G,Spanò E,Gennari C

    更新日期:2000-06-01 00:00:00