Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil.

abstract：BACKGROUND:Computerized ambulatory monitoring provides real-time assessments of clinical outcomes in natural contexts, and it has been increasingly applied in recent years to investigate symptom expression in a wide range of disorders. The purpose of this study was to examine the feasibility and validity of this data c...

journal_title：Neurology

authors： Johnson EI,Sibon I,Renou P,Rouanet F,Allard M,Swendsen J

更新日期：2009-11-10 00:00:00

abstract：OBJECTIVE:Diagnostic criteria from 2002 classify transverse myelitis (TM) as idiopathic or disease associated but predate the discovery of aquaporin-4 (AQP4)-immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which associate with TM. Prior incidence estimates of idiopathic TM (ITM) range from 1 t...

journal_title：Neurology

authors： Sechi E,Shosha E,Williams JP,Pittock SJ,Weinshenker BG,Keegan BM,Zalewski NL,Lopez-Chiriboga AS,Jitprapaikulsan J,Flanagan EP

更新日期：2019-07-23 00:00:00

abstract：:The authors assessed the referral pattern and outcome in patients with Guillain-Barré syndrome (n = 266) after the introduction of intravenous immunoglobulin (IVIg). Fewer patients were transferred from small to large hospitals after the introduction of IVIg (p = 0.05). This did not result in a worse outcome in patien...

journal_title：Neurology

authors： Van Koningsveld R,Van Doorn PA,Schmitz PI,Van der Meché FG

更新日期：2001-02-27 00:00:00

abstract：:We determined the horizontal and vertical components of brain displacement on coronal MRIs in 10 patients with acute supratentorial masses. The vertical distances from the superior sagittal sinus to the pontomesencephalic junction (PMJ) and from the vertical midline of the brain to the PMJ did not differ from measurem...

journal_title：Neurology

authors： Ropper AH

更新日期：1989-05-01 00:00:00

abstract：:The relationship between multiple sclerosis (MS) and primary Sjögren's syndrome (PSS) is ambiguous; it was suggested that some patients diagnosed with MS may instead have PSS. In a recent epidemiologic study, the prevalence of PSS was 2.7% in southern Sweden. We randomly selected 30 patients with definite MS from our ...

journal_title：Neurology

authors： Sandberg-Wollheim M,Axéll T,Hansen BU,Henricsson V,Ingesson E,Jacobsson L,Larsson A,Lieberkind K,Manthorpe R

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...

journal_title：Neurology

authors： Chandra V,Ganguli M,Pandav R,Johnston J,Belle S,DeKosky ST

更新日期：1998-10-01 00:00:00

abstract：:Many advances in prevention, diagnosis, and treatment of neurologic disease have emerged in the last few decades, resulting in reduced mortality and decreased disability. However, these advances have not benefitted all populations equally. A growing body of evidence indicates that barriers to care fall along racial an...

journal_title：Neurology

authors： Marulanda-Londoño ET,Bell MW,Hope OA,Leacock RO,O'Carroll CB,Posas J 3rd,Stover NP,Young R,Hamilton R

更新日期：2019-02-05 00:00:00

abstract：OBJECTIVE:To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. METHODS:The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, res...

journal_title：Neurology

authors： Siegel AM,Cascino GD,Meyer FB,McClelland RL,So EL,Marsh WR,Scheithauer BW,Sharbrough FW

更新日期：2004-12-28 00:00:00

abstract：:We investigated the modulatory effects of human interferon beta (IFN-beta) and gamma (IFN-gamma) on expression of class I and II major histocompatibility complex (MHC) antigens and intercellular adhesion molecule-1 (ICAM-1) in fetal human astrocytes in culture using flow cytometry and immunocytochemistry. Under the ba...

journal_title：Neurology

authors： Satoh J,Paty DW,Kim SU

更新日期：1995-02-01 00:00:00

abstract：:Many studies have demonstrated that dipyridamole is not purely an antiplatelet agent but also exerts its antithrombotic properties through the vessel wall. Using a laboratory model in which bovine endothelial cells are seeded to form a subendothelial matrix (SEM), investigators have shown that dipyridamole enhances th...

journal_title：Neurology

authors： Eisert WG

更新日期：2001-01-01 00:00:00

abstract：:The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...

journal_title：Neurology

authors： Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

更新日期：1979-11-01 00:00:00

abstract：:Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...

journal_title：Neurology

authors： Buchhalter JR,Dichter MA

更新日期：1986-02-01 00:00:00

abstract：:To determine if there is abnormal phenylalanine and biopterin metabolism in patients with dopa-responsive dystonia (DRD), we measured plasma levels of phenylalanine, tyrosine, biopterin, and neopterin at baseline, and 1, 2, 4, and 6 hours after an oral phenylalanine load (100 mg/kg). Seven adults with DRD, two severel...

journal_title：Neurology

authors： Hyland K,Fryburg JS,Wilson WG,Bebin EM,Arnold LA,Gunasekera RS,Jacobson RD,Rost-Ruffner E,Trugman JM

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS:A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 200...

journal_title：Neurology

authors： Wallin MT,Culpepper WJ,Campbell JD,Nelson LM,Langer-Gould A,Marrie RA,Cutter GR,Kaye WE,Wagner L,Tremlett H,Buka SL,Dilokthornsakul P,Topol B,Chen LH,LaRocca NG,US Multiple Sclerosis Prevalence Workgroup.

更新日期：2019-03-05 00:00:00

abstract：:Proteins from single frozen sections of human muscle were separated by two-dimensional gel electrophoresis and detected by fluorography or Coomassie Blue staining. The major proteins were identical in different normal muscles obtained from either sex at different ages, and in Duchenne and myotonic dystrophy samples. C...

journal_title：Neurology

authors： Giometti CS,Danon MJ,Anderson NG

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVE:To report the CNS syndromes of patients ≥60 years of age with antibodies against neuronal surface antigens but no evidence of brain MRI and CSF inflammatory changes. METHODS:This was a retrospective clinical analysis of patients with antibodies against neuronal surface antigens who fulfilled 3 criteria: age ...

journal_title：Neurology

authors： Escudero D,Guasp M,Ariño H,Gaig C,Martínez-Hernández E,Dalmau J,Graus F

更新日期：2017-10-03 00:00:00

abstract：:Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...

journal_title：Neurology

authors： Landau WM,Torack RM,Guggenheim MA

更新日期：1976-09-01 00:00:00

abstract：:Fatal familial insomnia (FFI), a condition characterized by inability to sleep, dysautonomia, motor disturbances, and selective thalamic atrophy is a prion disease linked to a GAC----AAC mutation at codon 178 of the prion gene. These data were obtained from one kindred. We now report a second kindred affected by FFI a...

journal_title：Neurology

authors： Medori R,Montagna P,Tritschler HJ,LeBlanc A,Cortelli P,Tinuper P,Lugaresi E,Gambetti P

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome, and multifocal motor neuropathy, and to determine the added...

journal_title：Neurology

authors： Herraets IJT,Goedee HS,Telleman JA,van Eijk RPA,van Asseldonk JT,Visser LH,van den Berg LH,van der Pol WL

更新日期：2020-04-07 00:00:00

abstract：:Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...

journal_title：Neurology

authors： Parker WD Jr

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/METHODS:We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. I...

journal_title：Neurology

authors： Jackson CE,Amato AA,Bryan WW,Wolfe GI,Sakhaee K,Barohn RJ

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To determine whether longitudinal cognitive decline is associated with increased risk of sleep disturbance in older, nondemented, community-dwelling women. METHODS:We studied 2,474 women (mean age 68.9 years) who were part of a prospective study started in 1986; women with baseline or follow-up evidence of p...

journal_title：Neurology

authors： Yaffe K,Blackwell T,Barnes DE,Ancoli-Israel S,Stone KL,Study of Osteoporotic Fractures Group.

更新日期：2007-07-17 00:00:00

abstract：OBJECTIVE:We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with irinotecan (CPT-11) while participating in the BRAIN study. METHODS:An independent neuroradiologist reviewed MRI scans at baseline and progression in patient...

journal_title：Neurology

authors： Pope WB,Xia Q,Paton VE,Das A,Hambleton J,Kim HJ,Huo J,Brown MS,Goldin J,Cloughesy T

更新日期：2011-02-01 00:00:00

abstract：:Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. ...

journal_title：Neurology

authors： Shelton GD,Cardinet GH,Lindstrom JM

更新日期：1988-09-01 00:00:00

abstract：:A specific form of deep cerebral hemisphere infarction was identified in 11 of 1,600 stroke register patients. Despite the CT finding of a deep striatocapsular lesion, these patients showed evidence of both cortical and capsular abnormalities. Angiography showed significant proximal carotid artery lesions as well as e...

journal_title：Neurology

authors： Bladin PF,Berkovic SF

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). METHODS:Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. After a 1-week washout they crossed over to the...

journal_title：Neurology

authors： Garcia-Borreguero D,Larrosa O,de la Llave Y,Verger K,Masramon X,Hernandez G

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To assess the relationship between CSF creatine kinase BB isoenzyme activity (CSF CKBB) and neurologic outcome after cardiac arrest in clinical practice. BACKGROUND:CSF CKBB reflects the extent of brain damage following cardiac arrest. METHODS:To help with prognosis, treating physicians ordered CSF CKBB tes...

journal_title：Neurology

authors： Tirschwell DL,Longstreth WT Jr,Rauch-Matthews ME,Chandler WL,Rothstein T,Wray L,Eng LJ,Fine J,Copass MK

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...

journal_title：Neurology

authors： Budhiraja R,Javaheri S,Pavlova MK,Epstein LJ,Omobomi O,Quan SF

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...

journal_title：Neurology

authors： Simon JH,Kinkel RP,Jacobs L,Bub L,Simonian N

更新日期：2000-03-14 00:00:00

abstract：OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...

journal_title：Neurology

authors： Alroughani R,Alowayesh MS,Ahmed SF,Behbehani R,Al-Hashel J

更新日期：2018-03-06 00:00:00