[Pulmonary involvement in the course of cytomegalovirus infection in an immunocompetent adult].

Abstract:

INTRODUCTION:Cytomegalovirus (CMV) infection in the immunocompetent is generally silent or it may present as a mononucleosis like syndrome but, rarely, it can lead to symptomatic manifestations. CASE REPORT:An immunocompetent and previously healthy 43- year-old woman presented with fever, dyspnoea, liver cell necrosis and a mononucleosis syndrome. The CT scan showed diffuse ground-glass opacity. BAL and blood cultures were sterile. Urinary antigens (Legionella pneumophila, Streptococcus pneumoniae) and serology for atypical respiratory pathogens (Mycoplasma pneumoniae and Chlamydia sp.) were negative. A diagnosis of CMV pneumonia was established on serology (presence of anti-CMV IgM) and PCR detection of viral DNA in the serum. Without antiviral therapy, there was a favourable clinical outcome 1 week later and 1 month later the CT scan was normal. CONCLUSION:CMV infection can lead, exceptionally. to a hypoxic pneumonia in the immunocompetent host. Antiviral therapy should not be prescribed systematically.

journal_name

Rev Mal Respir

authors

Margery J,Lefebvre N,Dot JM,Gervaise A,Andriamanantena D,Dieudonné M,Girodeau A

doi

10.1016/s0761-8425(09)70134-2

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

53-6

issue

1

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(09)70134-2

journal_volume

26

pub_type

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