Semiological differences of focal onset bilateral motor (convulsive) seizure between mesial temporal lobe epilepsy and neocortical epilepsy.

abstract：:Single photon emission computed tomography (SPECT) has frequently been used to investigate cerebral brain perfusion (CBP) occurring ictally and inter-ictally in epileptic patients. Several studies have addressed the multimodal analysis of the modifications occurring in cerebral areas involved in seizure activity, by c...

journal_title：Epilepsy research

authors： Marrosu F,Puligheddu M,Giagheddu M,Cossu G,Piga M

更新日期：2000-06-01 00:00:00

abstract：:Acute psychological disorders (APDs) are more common in epilepsy than in the general population, with estimates varying from 2 to 16% depending on the population of patients sampled. APD has traditionally been classified by seizure activity (ictal), the early post-ictal period (post-ictal) and unrelated to seizure act...

journal_title：Epilepsy research

authors： Cockerell OC,Moriarty J,Trimble M,Sander JW,Shorvon SD

更新日期：1996-10-01 00:00:00

abstract：:Metalloproteinase 9 (MMP9) is a member of a family of enzymes that mediate the degradation of extracellular matrix proteins, and is especially involved in blood-brain barrier maintenance. Increased levels of MMP9 have been observed in many neurological disorders, including epilepsy, suggesting it may be involved in th...

journal_title：Epilepsy research

authors： Cudna A,Jopowicz A,Mierzejewski P,Kurkowska-Jastrzębska I

更新日期：2017-01-01 00:00:00

abstract：:We report an interaction between lamotrigine (LTG), a new antiepileptic drug (AED), and carbamazepine (CBZ) and its primary metabolite CBZ-10,11-epoxide (CBZ-E) in 9 consecutive patients (5 male, 4 female, aged 19-31 years). After introduction of LTG (median daily dose 200 mg, range 100-300 mg) the mean serum CBZ-E co...

journal_title：Epilepsy research

authors： Warner T,Patsalos PN,Prevett M,Elyas AA,Duncan JS

更新日期：1992-04-01 00:00:00

abstract：:Benign childhood epilepsy with occipital paroxysms is classified among childhood benign partial epilepsies. The absence of neurological and neuropsychological deficits has long been considered as a prerequisite for a diagnosis of benign childhood partial epilepsy. Much evidence has been reported in literature in the l...

journal_title：Epilepsy research

authors： Germanò E,Gagliano A,Magazù A,Sferro C,Calarese T,Mannarino E,Calamoneri F

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To assess functional organization of the motor cortex in patients with Unverricht-Lundborg disease (EPM1A) using a combined neurophysiologic and imaging approach. METHODS:EPM1A patients underwent transcranial magnetic stimulation (TMS)-based cortical mapping of the motor hand area. Moreover, they performed n...

journal_title：Epilepsy research

authors： Rossi Sebastiano D,Visani E,Contarino VE,Panzica F,Duran D,D'Incerti L,Franceschetti S,Canafoglia L

更新日期：2020-02-01 00:00:00

abstract：:Weak relationships have been reported between subjective complaints of memory deficits and memory performance in neuropsychological tests in patients with temporal lobe epilepsy (TLE). This study investigated whether the individual exposure to cognitive demands in daily life contributes to cancel out the performance-c...

journal_title：Epilepsy research

authors： Gleissner U,Helmstaedter C,Quiske A,Elger CE

更新日期：1998-11-01 00:00:00

abstract：:Mutations in GABRG2, which encodes the γ2 subunit of GABAA receptors, can cause both genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. Most GABRG2 truncating mutations associated with Dravet syndrome result in premature termination codons (PTCs) and are stably translated into mutant proteins wit...

journal_title：Epilepsy research

authors： Ishii A,Kanaumi T,Sohda M,Misumi Y,Zhang B,Kakinuma N,Haga Y,Watanabe K,Takeda S,Okada M,Ueno S,Kaneko S,Takashima S,Hirose S

更新日期：2014-03-01 00:00:00

abstract：:We examined the influence of seizures and carbamazepine (CBZ) on spiking rates in kindled cats. In the first experiment, spiking rates were measured before and after seizures, with and without CBZ. CBZ was administered immediately after seizures in order not to affect them. Spiking rates were measured over 9 h during ...

journal_title：Epilepsy research

authors： Gigli GL,Gotman J

更新日期：1991-04-01 00:00:00

abstract：:An earlier pharmacodynamic study of the chiral antiepileptic drug stiripentol in an intravenous pentylenetetrazol-induced seizure model in the rat showed the development of a significant degree of tolerance to the anticonvulsant and neurotoxic effects following subacute treatment with the racemic compound. A more rece...

journal_title：Epilepsy research

authors： Arends RH,Zhang K,Levy RH,Baillie TA,Shen DD

更新日期：1994-06-01 00:00:00

abstract：:Focal epilepsy (FE) is one of the most common forms of adult epilepsy and is usually regarded as a multifactorial disorder. Febrile seizures (FS) often appear during childhood in a subtype of FE patients, i.e. with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). FS are the most common human convulsive eve...

journal_title：Epilepsy research

authors： Belhedi N,Perroud N,Karege F,Vessaz M,Malafosse A,Salzmann A

更新日期：2014-01-01 00:00:00

abstract：:The objective of the study was to explore clinical, electroencephalography (EEG), neuropsychological features and prognosis of myoclonic-astatic epilepsy (MAE). Of 327 children aged between 1 and 9 years with a diagnosis of generalized epilepsy followed between 2000 and 2008, 18 (5.5%) had MAE. Male significantly pred...

journal_title：Epilepsy research

authors： Trivisano M,Specchio N,Cappelletti S,Di Ciommo V,Claps D,Specchio LM,Vigevano F,Fusco L

更新日期：2011-11-01 00:00:00

abstract：:The purpose of this investigation was to inquire into the multietiological determinants of psychopathology and social competence in children with epilepsy. The relationship between behavioral functioning as assessed by the Child Behavior Checklist and a variety of biological, psychosocial, medication and demographic r...

journal_title：Epilepsy research

authors： Hermann BP,Whitman S,Hughes JR,Melyn MM,Dell J

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Cases of temporal lobe epilepsy (TLE) with ipsilateral amygdala enlargement (AE) have increasingly been reported. However, the white matter (WM) abnormalities of TLE patients with AE remain poorly investigated. Here we explored macrostructural and microstructural WM abnormalities in TLE patients with AE compare...

journal_title：Epilepsy research

authors： Sone D,Ota M,Maikusa N,Kimura Y,Sumida K,Yokoyama K,Imabayashi E,Watanabe M,Watanabe Y,Okazaki M,Sato N,Matsuda H

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

journal_title：Epilepsy research

authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

更新日期：2006-08-01 00:00:00

abstract：:There is increasing clinical and experimental evidence that hormones, in particular sex steroid hormones, influence neuronal excitability and other brain functions. The term 'neuroactive steroids' has been coined for steroids that interact with neurotransmitter receptors. One of the best characterized actions of neuro...

journal_title：Epilepsy research

authors： Beyenburg S,Stoffel-Wagner B,Bauer J,Watzka M,Blümcke I,Bidlingmaier F,Elger CE

更新日期：2001-05-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00

abstract：:The potential clinical efficacy of tiagabine for control of status epilepticus was evaluated in an experimental model. Tiagabine was administered to cobalt-lesioned rats in which status epilepticus was induced by injection of homocysteine thiolactone. Tiagabine was effective in controlling status epilepticus in this m...

journal_title：Epilepsy research

authors： Walton NY,Gunawan S,Treiman DM

更新日期：1994-12-01 00:00:00

abstract：:The ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment of intractable epilepsy. Recent studies suggest that the KD may be both anticonvulsant and antiepileptogenic. Epileptic seizures have been shown to stimulate the proliferation rate of neuronal progenitor cells in...

journal_title：Epilepsy research

authors： Kwon YS,Jeong SW,Kim DW,Choi ES,Son BK

更新日期：2008-02-01 00:00:00

abstract：:In the brain, injury-induced gliosis and axonal sprouting have been regarded as age-dependent repairing processes with, unfortunately, epileptogenic effects. The present study examines whether brains injured at different developmental stages become more or less susceptible to experimentally-induced status epilepticus....

journal_title：Epilepsy research

authors： Setkowicz Z,Janeczko K

更新日期：2003-03-01 00:00:00

abstract：:Developmental changes of transport of drugs into the brain play an important role in ontogenetic neuropharmacology. Two convulsant drugs with different mechanisms of action (glutamate and bicuculline methiodide) were chosen to demonstrate these changes in developing rats. High dose of glutamate (4 g/kg i.p.) induced b...

journal_title：Epilepsy research

authors： Mares P,Chino M,Kubová H,Mathern P,Veliký M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Polyunsaturated fatty acids have been reported to increase seizure threshold and to reduce seizure duration and severity in rats. OBJECTIVE:The purpose of the present study was to test the anticonvulsant effects of an essential fatty acid mixture containing linoleic and alpha-linolenic acids at a 4:1 ratio ...

journal_title：Epilepsy research

authors： Taha AY,Baghiu BM,Lui R,Nylen K,Ma DW,Burnham WM

更新日期：2006-09-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine the histological effects of valproic acid (VPA) on the penis in prepubertal rats. METHODS:Twelve male Wistar rats (21-24 days old) were divided equally into 2 experimental groups, and given tap water (control group) or 300mg/kg/day VPA via gavage for 30 days. After t...

journal_title：Epilepsy research

authors： Kutlu O,Cansu A,Karagüzel E,Gürgen SG,Koç O,Gür M,Ozgür GK

更新日期：2012-05-01 00:00:00

abstract：:A brief review of kindling is provided, which highlights some important points of historical interest often overlooked by researchers. These points include the fact that the original rating scale of convulsive seizures presented by Racine 'EEG Clin. Neurophysiol 32 (1972) 281'. was based on amygdala kindling, and may ...

journal_title：Epilepsy research

authors： McIntyre DC,Poulter MO,Gilby K

更新日期：2002-06-01 00:00:00

abstract：:In the present study, L-pGlu-(1-benzyl)-L-His-L-ProNH(2) (NP-355), a newer CNS active thyrotropin-releasing hormone (TRH) analog was evaluated for its antiepileptic potential. NP-355 (5, 10 and 20 micromol/kg; i.v.) pretreatment significantly delayed onset and reduced the frequency of convulsions in pentylenetetrazole...

journal_title：Epilepsy research

authors： Rajput SK,Singh JN,Ingole S,Jain G,Kaur N,Monga V,Meena CL,Jain R,Sharma SS

更新日期：2009-12-01 00:00:00

abstract：AIM:Vitamin D (Vit D) has been considered as a neurosteroid and has a pivotal role in neuroprotection including epilepsy. Vit D regulator acts via a Vit D receptor (VDR). WAG/Rij rats have a genetically epileptic model of absence epilepsy with comorbidity of depression. The aim of the present study was to investigate t...

journal_title：Epilepsy research

authors： Aygun H,Ayyildiz M,Agar E

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS:We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome...

journal_title：Epilepsy research

authors： Ferlazzo E,Nikanorova M,Italiano D,Bureau M,Dravet C,Calarese T,Viallat D,Kölmel M,Bramanti P,De Santi L,Genton P

更新日期：2010-05-01 00:00:00

abstract：:Simultaneous electroencephalography-transcranial magnetic stimulation (EEG-TMS) investigates cortical reactivity to external perturbations. TMS evoked potentials (TEPs) have been described in normals during sleep and wake but not after sleep deprivation or in pathologically enhanced excitability, i.e., epilepsy. The a...

journal_title：Epilepsy research

authors： Del Felice A,Fiaschi A,Bongiovanni GL,Savazzi S,Manganotti P

更新日期：2011-09-01 00:00:00

abstract：:The Neurotoxicity Scale was devised as a patient-based report scale to assess the adverse effects of antiepileptic drugs on cognitive function. In a previous report we reported the clinical validity of the scale, tested in a double-blind randomized study, using a benzodiazepine in normal volunteers. In the present stu...

journal_title：Epilepsy research

authors： Aldenkamp AP,Baker GA

更新日期：1997-06-01 00:00:00

abstract：:Opioid peptide release was monitored in the amygdala and hippocampus of freely moving rats following a single oral administration of gabapentin using microdialysis. Extracellular opioid peptide levels were elevated above basal levels in the amygdala within the first 60 (54%) and 90 min (68%) after gabapentin administr...

journal_title：Epilepsy research

authors： Rocha L,Ondarza-Rovira R,Maidment NT

更新日期：1999-05-01 00:00:00