Abstract:
:For various reasons, data on smoking are frequently missing, or only partially available, in retrospective epidemiologic studies of occupational risk factors. In such situations, indirect methods may be used to evaluate the magnitude and direction of the potentially confounding effects of smoking. Such an evaluation can be made quantitatively or qualitatively. Here we describe both approaches. A specific problem relates to case-referent studies, where sampling variation in referent selection may limit the possibility of controlling for confounding by smoking, even when smoking data are available. We present data showing that estimates of risk from occupational exposures which are not controlled for smoking may be as accurate as estimates derived after controlling for smoking, when the number of referents is relatively small. The problem of interaction is also discussed. In the absence of smoking data, the investigator has no indication of how smoking and occupation jointly affect disease risk (eg, additively or multiplicatively). The multiplicative model is usually assumed. However, if exposure and smoking act independently (additively), rate ratios are diminished. In such situations, in the presence of negative confounding by smoking, rate ratios may actually even be less than one--also when exposure and disease are strongly related.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Axelson O,Steenland Kdoi
10.1002/ajim.4700130107subject
Has Abstractpub_date
1988-01-01 00:00:00pages
105-18issue
1eissn
0271-3586issn
1097-0274journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20896
更新日期:2010-12-01 00:00:00
abstract::A 5-year prospective analysis tests the hypothesis that coal miners who have impaired respiratory health also experience greater numbers of disability days due to occupational injury. Occupational and respiratory health information collected for the period 1977 through 1981 by the National Institute for Occupational S...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700070409
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The Oak Ridge, Tennessee Y-12 plant has operated as a nuclear materials fabrication plant since the 1940s. Given the work environment, and prior findings that lung cancer mortality was elevated among white male Y-12 workers relative to US white males, we investigated whether lung cancer mortality was associa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20254
更新日期:2006-02-01 00:00:00
abstract::Exposure evaluation for epidemiology has special requirements, which can be derived from the pharmacological processes that determine the exposure-effect relationship. Since environmental concentrations of toxic agents typically are highly variable over time, the tissue concentrations they produce will vary over time,...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120303
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Harvesting of blueberries is associated with musculoskeletal injury. This study assessed the effects of several alternative designs of the harvesting rake. METHODS:A community-based work team selected rake design for intervention and pilot tested potential design modifications to the blueberry harvesting ra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20554
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Despite their legal rights, individuals with disabilities face numerous obstacles to integration in the workplace which can result in their discharge from the labor force. Currently occupational physicians have few resources to help decide whether to integrate disabled workers in pre-placement, or in cases o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22818
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Use of surrogate responders often needs to be considered in case-control studies with a high case fatality. METHODS:Agreement between 98 colon cancer patients and their closest relative was expressed as a percentage of the exact agreement and by Kappa coefficients and intra-class correlation coefficients. ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10266
更新日期:2003-09-01 00:00:00
abstract::Pressure from the vinyl chloride (VC) industry on researchers involved in industry-sponsored studies and on regulatory agencies has been documented since 1970s. This commentary describes the influence of a lawsuit pursued by workers of an Italian VC plant on the recent scientific debate on VC exposure and risk of hepa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20941
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Lead stabilizers (e.g., lead sulfate, lead stearate) are common additives in plastics used in electrical devices. In 1997, three plastics compounders at one California company were severely lead-poisoned. METHODS:The poisonings were investigated by interviewing the workers, employer, and treating physician ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20123
更新日期:2005-02-01 00:00:00
abstract::Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference B...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250127
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:An investigation of a small private agate mill was prompted by an agate worker who presented with silicosis in Guangzhou, China, in December 1998. METHODS:The work processes and records of dust measurements of the mill were examined. The mean total dust concentrations ranged from 3.0 to 9.9 mg/m3; 86-88% of...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1074
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:The Deepwater Horizon disaster cleanup effort provided an opportunity to examine the effects of ambient thermal conditions on exertional heat illness (EHI) and acute injury (AI). METHODS:The outcomes were daily person-based frequencies of EHI and AI. Exposures were maximum estimated WBGT (WBGTmax) and sever...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22650
更新日期:2016-12-01 00:00:00
abstract::Cause-specific mortality was evaluated by period of hire for 37,682 male chemical workers in order to test the hypothesis that employees hired during World War II (1941-1945) were at increased risk for selected causes of death. One recent study of refinery workers reported that those hired during the war years had exp...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150308
更新日期:1989-01-01 00:00:00
abstract::Since 1988, the National Institute for Occupational Safety and Health (NIOSH) has notified workers who were subjects in occupational epidemiology studies of the study findings ("worker notification"). This paper describes seven notifications and the worker's reactions to them. The chemicals of interest in the studies ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270403
更新日期:1995-04-01 00:00:00
abstract::A microcomputer system for on-lone analysis of saccadic and smooth-pursuit tracking eye movements is described. Results from a longitudinal study of lead workers and matched controls reveal a consistent decrease in saccade accuracy in the lead workers compared to the controls. Saccade peak velocity and latency and smo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700010112
更新日期:1980-01-01 00:00:00
abstract::Lifetime industrial and occupational histories of women with a medically-confirmed diagnosis of infertility (n = 281) were compared to a group of postpartum women (n = 216) for risks of infertility. Controlling for age of first pregnancy or self-report of infertility, date of outcome, cigarette use, and employment in ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199704)31:4<445::aid-ajim1
更新日期:1997-04-01 00:00:00
abstract::In 1979, a pilot survey defined respiratory status and unmet health care needs of retired and former male asbestos workers in Hawaii. Of 1,401 identified subjects, 741 were contacted and 411 were interviewed. Forty-five subjects were between 39 and 54 years of age; 208, between 55 and 64; and 158, age 65 or more. They...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700060208
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Sickness benefit claims are an important economic burden to society. This study aims to determine the incidence of sickness benefit claims in Brazil in 2008, exploring the role of economic activity. METHODS:Population-based study on sickness claims lasting longer than 15 days of sickness absence granted to ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20974
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compile nationally representative statistics describing inpatient hospital care for patients with work-related injuries and illnesses covered under workers' compensation (WC) insurance in the United States. METHODS:Three years of data (1997-1999) from the Nationwide Inpatient Sa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10273
更新日期:2003-10-01 00:00:00
abstract::Several studies on the mortality of chemists have revealed a lower overall mortality but an excess of deaths from certain diseases, in particular, cancers. This study determined the causes of mortality of 4,012 chemists among 14,884 members of The Royal Society of Chemistry who were followed for a period of 25 years. ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230409
更新日期:1993-04-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150103
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the prevalence of hand paresthesias (HP) and their relationship with pruning activities. METHODS:A cross-sectional study was conducted among 537 workers pruning grapevines in the region of Champagne. All workers completed a questionnaire about nocturnal HP and musculoskele...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10012
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Persistent and growing occupation-based disparities related to tobacco pose a serious public health challenge. Tobacco exacts a disproportionate toll on individuals employed in working class occupations, due to higher prevalence of smoking and exposure to secondhand smoke among these workers compared to othe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20026
更新日期:2004-08-01 00:00:00
abstract::This report describes the reanalysis of a cross-sectional study of asthma in a large cohort of autoworkers with exposure to metalworking fluids (MWF). There is strong evidence from case reports, clinical studies, and medical surveillance data that exposure to MWF can cause asthma, yet no association was found in the o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199706)31:6<671::aid-ajim1
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:The Mine Safety and Health Administration (MSHA) proposes to issue citations for non-compliance with the exposure limit for respirable coal mine dust when measured exposure exceeds the exposure limit with a "high degree of confidence." This criterion threshold value (CTV) is derived from the sampling and ana...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20318
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Fish processing is a common economic activity in Southern Africa. The aim of this study was to determine the prevalence and host determinants of allergic symptoms, allergic sensitization, bronchial hyper-responsiveness and asthma among workers processing saltwater fish. METHODS:A cross-sectional study was c...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20635
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Thoroughbred horse farm workers self-report a high frequency of work-related injuries and pain. However, an analysis of Thoroughbred horse farm workers' compensation injury claims is absent from the literature, yet may benefit worker safety. METHODS:We analyzed workers' compensation insurance firm data cont...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23159
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Multiple comorbidities have been reported among rescue/recovery workers responding to the 9/11/2001 WTC disaster. In this study, we developed an index that quantifies the cumulative physiological burden of comorbidities and predicts life expectancy in this cohort. METHODS:A machine learning approach (gradie...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22786
更新日期:2018-01-01 00:00:00
abstract::Occupational health studies of agricultural workers have generally excluded migrant and seasonal farmworkers, and this population experiences a high degree of health risk from agricultural exposures. A survey of dermatologic disorders among migrant and seasonal farmworkers will be used to illustrate this point. Data f...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180317
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The community of Libby, Montana has recently been the focus of national attention secondary to widespread amphibole contamination associated with vermiculite mining and processing. METHODS:Patients who had occupational and non-occupational exposure to amphibole asbestos in Libby, Montana were evaluated for ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20053
更新日期:2004-09-01 00:00:00