Abstract:
:Background: Prescription Drug Monitoring Programs (PDMPs) collect controlled substance prescriptions dispensed within a state. Many PDMP programs perform targeted outreach (i.e., "unsolicited reporting") for patients who exceed numerical thresholds, however, the degree to which patients at highest risk of fatal opioid overdose are identified has not been compared with one another or with a predictive model. Methods: A retrospective analysis was performed using statewide PDMP data for Maryland residents aged 18 to 80 years with an opioid fill between April to June 2015. The outcome was opioid-related overdose death in 2015 or 2016. A multivariable logistic regression model and three PDMP thresholds were evaluated: (1) multiple provider episodes; (2) high daily average morphine milligram equivalents (MME); and (3) overlapping opioid and benzodiazepine prescriptions. Results: The validation cohort consisted of 170,433 individuals and 244 deaths. The predictive model captured more individuals who died (46.3% of total deaths) and had a higher death rate (7.12 per 1000) when the risk score cutoff (0.0030) was selected for a comparable size of high-risk individuals (n = 15,881) than those meeting the overlapping opioid/benzodiazepine prescriptions (n = 17,440; 33.2% of total deaths; 4.64 deaths per 1000) and high MME (n = 14,675; 24.6% of total deaths; 4.09 deaths per 1000) thresholds. Conclusions: The predictive model identified more individuals at risk of fatal opioid overdose as compared with PDMP thresholds commonly used for unsolicited reporting. PDMP programs could improve their targeting of unsolicited reports to reach more individuals at risk of overdose by using predictive models instead of simple threshold-based approaches.
journal_name
Subst Use Misusejournal_title
Substance use & misuseauthors
Ferris LM,Saloner B,Jackson K,Lyons BC,Murthy V,Kharrazi H,Latimore A,Stuart EA,Weiner JPdoi
10.1080/10826084.2020.1868520subject
Has Abstractpub_date
2021-01-15 00:00:00pages
1-8eissn
1082-6084issn
1532-2491pub_type
杂志文章abstract:BACKGROUND:Although integrated programs between child welfare and substance abuse treatment are recommended for families with co-occurring child maltreatment and substance use disorders, implementing integrated service delivery strategies with fidelity is a challenging process. OBJECTIVE:This study of the first five y...
journal_title:Substance use & misuse
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doi:10.3109/10826084.2015.1013131
更新日期:2015-01-01 00:00:00
abstract::Communication of accurate, objective, and timely scientific information to treatment professionals is important--especially in the "drug abuse" and addiction field where misinformation and a lack of exposure to new information are common. The purpose of this study was to assess knowledge and belief changes that accomp...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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abstract:BACKGROUND:Information on e-cigarettes among youth in the Russian Federation is lacking. OBJECTIVE:We examined prevalence of and factors associated with youth e-cigarette use in the Russian Federation. METHODS:A cross-sectional, anonymous survey, conducted among 716 (females 51.5%) high school students in three citie...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2013.796989
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abstract:BACKGROUND:While there is evidence for socioeconomic inequalities in some adolescent substance use behaviors, there is limited information on how socioeconomic inequalities compare across European countries and over time. OBJECTIVES:To compare socioeconomic inequalities in problematic adolescent substance use (regular...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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doi:10.1080/10826084.2019.1686021
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journal_title:Substance use & misuse
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abstract:BACKGROUND:Alcohol use/misuse is a prevalent health issue among youth and may lead to adverse consequences. Religiosity has been identified as a protective factor against alcohol use/misuse among youth. Identifying moderators in the religiosity-alcohol relationship has important implications for intervention developmen...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2018.1555598
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826089709035627
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826089709035617
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abstract:BACKGROUND:Global estimates suggest there are 15.6 million people who inject drugs (PWID) of whom 17.8% are living with HIV.Few studies have characterized newly-onset injectors with long-term injectors and its association with injecting risk behaviors. OBJECTIVES:We examined the relationship between length of injectio...
journal_title:Substance use & misuse
pub_type: 杂志文章
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2018.1458319
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journal_title:Substance use & misuse
pub_type: 杂志文章,评审
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更新日期:2000-10-01 00:00:00
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journal_title:Substance use & misuse
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更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.3109/10826089909037228
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journal_title:Substance use & misuse
pub_type: 杂志文章,多中心研究
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journal_title:Substance use & misuse
pub_type: 杂志文章,评审
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journal_title:Substance use & misuse
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doi:10.3109/10826089809115895
更新日期:1998-02-01 00:00:00
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journal_title:Substance use & misuse
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doi:10.3109/10826089609045795
更新日期:1996-01-01 00:00:00
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doi:10.3109/10826084.2016.1160120
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abstract::Although khat (Catha edulis) is not widely known outside its countries of production in East Africa and Yemen, it evokes strong views among consumers, development workers, and government officials who often behave as self-styled experts on the drug. Yet, the evidence of harm to health is scant. As khat consumption has...
journal_title:Substance use & misuse
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doi:10.1080/10826080701739057
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abstract::This 2005 study compared parent-child attachment in 89 American female Adult Children of Alcoholics (ACOAs) as compared to 201 non-ACOAs. Women attended a large university in the southeastern United States. Participants categorized as ACOA on the Children of Alcoholics Screen Test (CAST; Jones, 1983) reported signific...
journal_title:Substance use & misuse
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doi:10.1080/10826080802240906
更新日期:2008-01-01 00:00:00
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