Evolutionary genetics of skin pigmentation in African populations.

Abstract:

:Skin color is a highly heritable human trait, and global variation in skin pigmentation has been shaped by natural selection, migration, and admixture. Ethnically diverse African populations harbor extremely high levels of genetic and phenotypic diversity, and skin pigmentation varies widely across Africa. Recent genome-wide genetic studies of skin pigmentation in African populations have advanced our understanding of pigmentation biology and human evolutionary history. For example, novel roles in skin pigmentation for loci near MFSD12 and DDB1 have recently been identified in African populations. However, due to an underrepresentation of Africans in human genetic studies, there is still much to learn about the evolutionary genetics of skin pigmentation. Here, we summarize recent progress in skin pigmentation genetics in Africans and discuss the importance of including more ethnically diverse African populations in future genetic studies. In addition, we discuss methods for functional validation of adaptive variants related to skin pigmentation.

journal_name

Hum Mol Genet

journal_title

Human molecular genetics

authors

Feng Y,McQuillan MA,Tishkoff SA

doi

10.1093/hmg/ddab007

subject

Has Abstract

pub_date

2021-01-12 00:00:00

eissn

0964-6906

issn

1460-2083

pii

6089124

pub_type

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