Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery.

Abstract:

:Self-assembled nanostructures that are sensitive to environmental stimuli are promising nanomaterials for drug delivery. In this class, disulfide-containing redox-sensitive strategies have gained enormous attention because of their wide applicability and simplicity of nanoparticle design. In the context of nucleic acid delivery, numerous disulfide-based materials have been designed by relying on covalent or noncovalent interactions. In this review, we highlight major advances in the design of disulfide-containing materials for nucleic acid encapsulation, including covalent nucleic acid conjugates, viral vectors or virus-like particles, dendrimers, peptides, polymers, lipids, hydrogels, inorganic nanoparticles, and nucleic acid nanostructures. Our discussion will focus on the context of the design of materials and their impact on addressing the current shortcomings in the intracellular delivery of nucleic acids.

journal_name

Biochemistry

journal_title

Biochemistry

authors

Dutta K,Das R,Medeiros J,Thayumanavan S

doi

10.1021/acs.biochem.0c00860

subject

Has Abstract

pub_date

2021-01-11 00:00:00

eissn

0006-2960

issn

1520-4995

pub_type

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