Abstract:
:Self-assembled nanostructures that are sensitive to environmental stimuli are promising nanomaterials for drug delivery. In this class, disulfide-containing redox-sensitive strategies have gained enormous attention because of their wide applicability and simplicity of nanoparticle design. In the context of nucleic acid delivery, numerous disulfide-based materials have been designed by relying on covalent or noncovalent interactions. In this review, we highlight major advances in the design of disulfide-containing materials for nucleic acid encapsulation, including covalent nucleic acid conjugates, viral vectors or virus-like particles, dendrimers, peptides, polymers, lipids, hydrogels, inorganic nanoparticles, and nucleic acid nanostructures. Our discussion will focus on the context of the design of materials and their impact on addressing the current shortcomings in the intracellular delivery of nucleic acids.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Dutta K,Das R,Medeiros J,Thayumanavan Sdoi
10.1021/acs.biochem.0c00860subject
Has Abstractpub_date
2021-01-11 00:00:00eissn
0006-2960issn
1520-4995pub_type
杂志文章相关文献
BIOCHEMISTRY文献大全abstract::Mismatches in DNA occur naturally during replication and as a result of endogenous DNA damaging agents, but the mismatch repair (MMR) pathway acts to correct mismatches before subsequent rounds of replication. Rhodium metalloinsertors bind to DNA mismatches with high affinity and specificity and represent a promising ...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi2015822
更新日期:2011-12-20 00:00:00
abstract::ALY is a ubiquitously expressed nuclear protein which interacts with proteins such as TAP that are involved in export of mRNA from the nucleus to the cytoplasm, as well as with proteins that bind the T cell receptor alpha gene enhancer. ALY has also been shown to bind mRNA and to co-localize in the nucleus with compon...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi034062o
更新日期:2003-06-24 00:00:00
abstract::We have developed a new genomic sequencing method for detecting, with resolution at the nucleotide level, the interstrand DNA cross-links induced by 4,5',8-trimethylpsoralen along single-copy genes in mammalian cells. The cross-links (diadducts) initially formed are converted into monoadducts by alkali reversal prior ...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi002539f
更新日期:2001-04-03 00:00:00
abstract::For the elucidation of the mechanism of steroid hormone receptor activation, the hydrodynamic properties of the unactivated and activated forms of the nonproteolyzed glucocorticoid receptor from the mouse AtT-20 pituitary tumor cell line were determined. The unactivated, molybdate-stabilized receptor has the following...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00277a038
更新日期:1983-04-12 00:00:00
abstract::Peptide nucleic acids (PNAs) are nonionic DNA/RNA mimics that can recognize complementary sequences by Watson-Crick base pairing. The neutral PNA backbone facilitates the recognition of duplex DNA by strand invasion, suggesting that antigene PNAs (agPNAs) can be important tools for exploring the structure and function...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi700230a
更新日期:2007-06-26 00:00:00
abstract::FHA domains are phosphoThr recognition modules found in diverse signaling proteins, including kinase-associated protein phosphatase (KAPP) from Arabidopsis thaliana. The kinase-interacting FHA domain (KI-FHA) of KAPP targets it to function as a negative regulator of some receptor-like kinase (RLK) signaling pathways i...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi061763n
更新日期:2007-03-13 00:00:00
abstract::Methylmalonyl-CoA mutase from Propionibacterium shermanii is an adenosylcobalamin-dependent enzyme which catalyzes the reversible isomerization of methylmalonyl-CoA and succinyl-CoA. The rate of tritium loss from 5'-[3H]adenosylcobalamin during the enzymic reaction and the relative rates of tritium appearance in subst...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi961250o
更新日期:1996-09-10 00:00:00
abstract::4-Chlorobenzoyl-coenzyme A (4-CBA-CoA) dehalogenase catalyzes the hydrolysis of 4-CBA-CoA to 4-hydroxybenzoyl-coenzyme A (4-HBA-CoA) via a nucleophilic aromatic substitution pathway involving the participation of an active site carboxylate side chain in covalent catalysis. In this paper we report on the identification...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi9609533
更新日期:1996-08-20 00:00:00
abstract::Nucleotide excision repair (NER) is a crucial pathway in the maintenance of genome stability requiring at least two dozen proteins. XPA and RPA have essential roles in the damage recognition step of NER. To better understand the mechanism of their interactions with DNA, we utilized equilibrium and stop-flow kinetic ap...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi011041q
更新日期:2002-01-08 00:00:00
abstract::As part of a larger effort to engineer the stability and hemin-binding properties of microsomal (Mc) cytochromes b(5) into rat liver outer mitochondrial membrane (OM) cytochrome (cyt) b(5), several mutants of rat OM cyt b(5) were prepared to study the effect of gradual and complete elimination of two extended hydropho...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi026005l
更新日期:2002-10-01 00:00:00
abstract::We have developed a system for targeting foreign DNA to hepatocytes in vitro using a soluble DNA carrier that takes advantage of receptor-mediated endocytosis to achieve internalization. The idea is based on the fact that hepatocytes possess a unique receptor that binds and internalizes galactose-terminal (asialo)glyc...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00403a008
更新日期:1988-02-09 00:00:00
abstract::A Ca(2+)-activated thiol protease was purified from Drosophila melanogaster. The procedure involves Phenyl-Sepharose, Reactive Red-Agarose and Q-Sepharose fast flow (or MonoQ) chromatographic steps. The enzyme eluting from Q-Sepharose fast flow seems to be homogeneous as judged by silver staining on SDS-PAGE: it consi...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00150a012
更新日期:1992-09-08 00:00:00
abstract::The repeating units of mouse, rat, and alpha-monkey satellites have been cloned. All three show properties that are characteristic of curved DNA: (i) their migration in polyacrylamide gels is slower than predicted from their sequences, and (ii) they appear as curved molecules when visualized by electron microscopy. Al...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00461a019
更新日期:1990-03-06 00:00:00
abstract::For expression in Saccharomyces cerevisiae the cDNA of the uncoupling protein (UCP) of brown adipose tissue from hamster has been isolated and used to transform yeast cells. Optimized expression conditions yielded 2% of mitochondrial protein as UCP. UCP was isolated, avoiding copurification of ADP/ATP carrier and pori...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi970513r
更新日期:1997-07-08 00:00:00
abstract::Membrane preparations from two independent ouabain-resistant HeLa cell clones, HI-B1 and HI-C1, each appear to contain two species of (Na,K)ATPase. Two-thirds of the total (Na,K)ATPase in each mutant is indistinguishable from the enzyme in preparations of wild type cells with respect to ouabain binding, ouabain inhibi...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00642a600
更新日期:1977-11-15 00:00:00
abstract::Tandem calponin-homology (CH) domains are the most common actin-binding domains in proteins. However, structural principles underlying their function are poorly understood. These tandem domains exist in multiple conformations with varying degrees of inter-CH-domain interactions. Dystrophin and utrophin tandem CH domai...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/acs.biochem.5b00741
更新日期:2015-09-08 00:00:00
abstract::On the basis of the available high-resolution structures of mandelate racemase (MR) from Pseudomonas putida [Landro, J. A., Gerlt, J. A., Kozarich, J. W., Koo, C. W., Shah, V. J., Kenyon, G. L., Neidhart, D. J., Fujita, J., & Petsko, G. A. (1994) Biochemistry 33, 635-643], Lys 166 and His 297 are positioned appropriat...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00009a007
更新日期:1995-03-07 00:00:00
abstract::The effect of DnaB helicase on the initiation specificity of primase was studied biochemically using a series of single-stranded DNA templates in which each nucleotide of the trinucleotide d(CTG) initiation sequence was systematically varied. DnaB helicase accelerated the rate of primer syntheisis, prevented "overlong...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi991555d
更新日期:2000-02-01 00:00:00
abstract::Translocator protein 18 kDa (TSPO) was previously known as the peripheral benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the mitochondrial outer membrane. Considerable evidence indicates that it plays regulatory roles in steroidogenesis and apoptosis and is involved in various human disea...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/acs.biochem.6b00142
更新日期:2016-05-24 00:00:00
abstract::Sedimentation in a preparative ultracentrifuge was used to determine the affinity of heavy meromyosin, HMM, for regulated actin, F-actin plus troponin-tropomyosin, in the presence of MgATP at pH 7.0, 20 degrees C, and mu = 18 mM. HMM was prepared from vertebrate striated muscle myosin by a mild chymotryptic digestion....
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00275a003
更新日期:1983-03-15 00:00:00
abstract::Aspartoacylase catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate and is the only brain enzyme that has been shown to effectively metabolize NAA. Although the exact role of this enzymatic reaction has not yet been completely elucidated, the metabolism of NAA appears to be nec...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi052608w
更新日期:2006-05-09 00:00:00
abstract::The thermotropic phase behavior of 10 mixed-chain phosphatidylcholines, in excess water, has been examined and compared with that of identical-chain C(16):C(16)PC by using high-resolution differential scanning calorimetry (DSC). The molecular weights (MW) of these 11 molecular species are the same, but their delta C/C...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00243a022
更新日期:1991-07-23 00:00:00
abstract::The reversible inhibition of beta-lactamase I from Bacillus cereus by cloxacillin, methicillin, and nafcillin has been systematically investigated. For these substrates the enzymatic reaction involves partitioning of the substrate between turnover and inhibition. Typically, concentrations of several hundred millimolar...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00388a011
更新日期:1987-07-14 00:00:00
abstract::The inactivation of cytochrome P450 2B4 by aldehydes in a reconstituted enzyme system requires molecular oxygen and NADPH and is not prevented by the addition of catalase, superoxide dismutase, epoxide hydrolase, glutathione, or ascorbic acid. A strong correlation between loss of enzymatic activity and bleaching of th...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi9630568
更新日期:1997-04-22 00:00:00
abstract::We have studied the effects of site-directed mutations in Escherichia coli nitrate reductase A (NarGHI) on heme reduction by a menaquinol analogue (menadiol) using the stopped-flow method. For NarGHI(H66Y) and NarGHI(H187Y), both lacking heme b(L) but having heme b(H), the heme reduction by menadiol is abolished. For ...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi0350856
更新日期:2003-12-09 00:00:00
abstract::The molecular weight of phosphophoryn, an acidic phosphoprotein unique to dentin matrix, has been difficult to determine because of a combination of neutral protease activities in this tissue and the intrinsic high charge density of the molecule. In this study, bovine dentin phosphophoryn (BDPP) was isolated by a proc...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00287a025
更新日期:1983-08-30 00:00:00
abstract::The interactions of the ligand binding domain (LBD) of androgen receptor (AR) and the AR T877A mutant, found in prostate cancer, with peptides from coactivator and corepressor proteins or random phage display peptides were investigated using in vitro time-resolved fluorescence resonance energy transfer (TR-FRET). Inte...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi061321b
更新日期:2007-01-23 00:00:00
abstract::Mycobacterium tuberculosis and many other members of the Actinomycetes family produce mycothiol, i.e., 1-d-myo-inosityl-2-(N-acetyl-l-cysteinyl)amido-2-deoxy-alpha-d-glucopyranoside (MSH or AcCys-GlcN-Ins), to act against oxidative and antibiotic stress. The biosynthesis of MSH is essential for cell growth and has bee...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi7011492
更新日期:2007-10-09 00:00:00
abstract::ArsR (or ArsR/SmtB) family metalloregulatory homodimeric repressors collectively respond to a wide range of metal ion inducers in regulating homeostasis and resistance of essential and nonessential metal ions in bacteria. BxmR from the cyanobacterium Osciliatoria brevis is the first characterized ArsR protein that sen...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi801313y
更新日期:2008-10-07 00:00:00
abstract::Two oxygenated iron-cobalt hybrid hemoglobins (Hbs), (alpha Co-O2 beta Fe-O2)2 and (alpha Fe-O2 beta Co-O2)2, were studied by electron spin echo envelope modulation (ESEEM) spectroscopy in order to measure (i) electron-nuclear hyperfine and nuclear quadrupole coupling to the N epsilon of the proximal histidyl imidazol...
journal_title:Biochemistry
pub_type: 杂志文章
doi:10.1021/bi00020a036
更新日期:1995-05-23 00:00:00