ChIP-based methods for the identification of long-range chromatin interactions.

abstract：:Liver selected B16-LS9 melanoma cells show a dramatic overexpression of the proto-oncogene c-met, the cellular receptor for hepatocyte growth factor/scatter factor. As a consequence, c-met becomes constitutively active, and the cells become more responsive to hepatocyte growth factor stimulation. We have investigated ...

journal_title：Journal of cellular biochemistry

authors： Elia G,Ren Y,Lorenzoni P,Zarnegar R,Burger MM,Rusciano D

更新日期：2001-01-01 00:00:00

abstract：:Papillary renal cell carcinoma (pRCC) is a heterogeneous disease containing multifocal or solitary tumors with an aggressive phenotype. Increasing evidence has indicated the involvement of aberrant splicing variants in renal cell cancer, while systematic profiling of aberrant alternative splicing (AS) in pRCC was lack...

journal_title：Journal of cellular biochemistry

authors： Duan Y,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that participate in the regulation of gene expression. Although many studies have demonstrated the involvement of miR-17-5p in different cancers, little is known to its function in ovarian cancer. In this study, we demonstrated that overexpression of miR-17-5p was able to ...

journal_title：Journal of cellular biochemistry

authors： Li L,He L,Zhao JL,Xiao J,Liu M,Li X,Tang H

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Endometrial carcinoma (EC), a common gynecological malignancy with high incidence, affects the mental and physical health of women. Mounting evidence shows that long noncoding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) have instrumental roles in various biological processes associated with t...

journal_title：Journal of cellular biochemistry

authors： Zhao D,Ren C,Yao Y,Wang Q,Li F,Li Y,Jiang A,Wang G

更新日期：2020-03-01 00:00:00

abstract：:Osteogenic differentiation refers to the process of bone formation and remodeling, which is controlled by complex molecular mechanisms. Activin A receptor type I (ACVR1) is reported to be associated with osteogenic differentiation. However, the underlying molecular mechanism remains elusive. Therefore, this study eval...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Sun JC,Wang HB,Xu XM,Kong QJ,Wang YJ,Zheng B,Shi GD,Shi JG

更新日期：2018-12-16 00:00:00

abstract：:Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM-1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen-priming T-cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells,...

journal_title：Journal of cellular biochemistry

authors： Jo JH,Kwon MS,Choi HO,Oh HM,Kim HJ,Jun CD

更新日期：2010-12-01 00:00:00

abstract：:Melanoma skin cancer is one of the main causes of male cancer-related deaths worldwide. It has been suggested that miR-330-5p can act as a tumor suppressor in various types of cancers. So, in this study, we replaced miR-330 in melanoma cancer cells by vector-based miR-330 to evaluate the effects of this microRNA on th...

journal_title：Journal of cellular biochemistry

authors： Sehati N,Sadeghie N,Mansoori B,Mohammadi A,Shanehbandi D,Baradaran B

更新日期：2020-01-01 00:00:00

abstract：:Sexual differences on thyroxin 5'-deiodinase (5'-D) in the Harderian gland of Syrian hamsters were investigated. We compared the 24-h profile of 5'-D activity in male and female hamsters, observing a clear rhythm in males but not in females. Female values were always significantly higher than male ones. After pinealec...

journal_title：Journal of cellular biochemistry

authors： Rubio A,Menendez-Pelaez A,Buzzell GR,Vaughan MK,Vaughan GM,Reiter RJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND/AIMS:Fibroblast growth factor 21 (FGF21) plays a protective role in ischemia/reperfusion induced cardiac injury. However, the exact molecular mechanism of FGF21 action remains unclear. This study was designed the protective effect of FGF21 on the heart and its mechanism. METHOD:Adenovirus vector expressing ...

journal_title：Journal of cellular biochemistry

authors： Sun M,Jin L,Bai Y,Wang L,Zhao S,Ma C,Ma D

更新日期：2019-12-01 00:00:00

abstract：:Human DNA replication depends on the activation of thousands of origins distributed within the genome. The actual distribution of origins is not known, nor whether this distribution is unique to a cell type, or if it changes with the proliferative state of the cell. In this study, we have employed a real-time PCR-base...

journal_title：Journal of cellular biochemistry

authors： Valenzuela MS,Hu L,Lueders J,Walker R,Meltzer PS

更新日期：2012-01-01 00:00:00

abstract：:Magnesium homeostasis in HL-60 promyelocytic leukemia cells was compared to that in neutrophyl-like HL-60 cells obtained by 1.3% DMSO treatment. Magnesium homeostasis was studied by the characterization of magnesium efflux, the identification of intracellular magnesium pools, and the regulation of intracellular ionize...

journal_title：Journal of cellular biochemistry

authors： Wolf FI,Covacci V,Bruzzese N,Di Francesco A,Sacchetti A,Corda D,Cittadini A

更新日期：1998-12-01 00:00:00

abstract：:In this study, we examined the effects of shark cartilage extract on the attachment and spreading properties and the focal adhesion structure of cultured bovine pulmonary artery endothelial cells. Treatment with cartilage extract resulted in cell detachment from the substratum. Immunofluorescence staining of those tre...

journal_title：Journal of cellular biochemistry

authors： Chen JS,Chang CM,Wu JC,Wang SM

更新日期：2000-06-06 00:00:00

abstract：:Lysophosphatidic acid (LPA) elicits diverse cellular responses through cell surface LPA receptors in nervous system-derived cells and cell lines. The developing nervous system is one of the major loci for LPA receptor expression. Recent studies have also revealed that metabolic pathways of LPA are present in the nervo...

journal_title：Journal of cellular biochemistry

authors： Fukushima N

更新日期：2004-08-01 00:00:00

abstract：:Both clinical and experimental evidence indicates that AIDS-related Kaposi's sarcoma (AIDS-KS) has a multifactorial pathogenesis with factors such as HIV viral load, latent virus induction, and opportunistic infections contributing to disease progression. However, a consistent feature that unites these apparently dive...

journal_title：Journal of cellular biochemistry

authors： Mallery SR,Landwehr DJ,Ness GM,Clark YM,Hohl CM

更新日期：1998-03-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor has recently been identified in bone, but the molecular composition of this receptor expressed by bone cells is unknown. NMDA receptor (NMDAR) is a hetero-oligomeric protein composed of two classes of subunits, the essential subunit NR1 and NR2A to D su...

journal_title：Journal of cellular biochemistry

authors： Itzstein C,Cheynel H,Burt-Pichat B,Merle B,Espinosa L,Delmas PD,Chenu C

更新日期：2001-04-02 00:00:00

abstract：:Diabetes mellitus (DM), one of the most prevalent metabolic diseases in the world population, is associated with a number of comorbid conditions including obesity, pancreatic endocrine changes, and renal and cardio-cerebrovascular alterations, coupled with peripheral neuropathy and neurodegenerative disease, some of t...

journal_title：Journal of cellular biochemistry

authors： Morsi M,Kobeissy F,Magdeldin S,Maher A,Aboelmagd O,Johar D,Bernstein L

更新日期：2019-09-01 00:00:00

abstract：:Deregulation and functional inhibition of CCAAT-enhancer-binding protein α (C/EBPα), a key transcription factor of myeloid lineage leads to development of myeloid leukemia. In this study, we show that cyclin-dependent kinase 2 (CDK2) negatively regulates C/EBPα protein levels in myeloid leukemia cells. The overexpress...

journal_title：Journal of cellular biochemistry

authors： Thacker G,Mishra M,Sharma A,Singh AK,Sanyal S,Trivedi AK

更新日期：2020-04-01 00:00:00

abstract：:Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to...

journal_title：Journal of cellular biochemistry

authors： Niu Z,Zhao X,Liu H,Quan J,Lin Y,Li J,Wang J,Liu M,Song W,Chen A,Liu S

更新日期：2018-06-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The C...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Huang T,Sun X,Wang Y

更新日期：2019-11-01 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymorphism (SNP) in the...

journal_title：Journal of cellular biochemistry

authors： Benbow U,Tower GB,Wyatt CA,Buttice G,Brinckerhoff CE

更新日期：2002-01-01 00:00:00

abstract：:In the present study, monoclonal antibodies were produced using porcine adipocyte extracts as the immunogen. Two of the monoclonal antibodies, designated CB6 and IB4, exhibited reactivity toward only cells containing lipid in stromal-vascular cell cultures. The antigens recognized by the CB6 and IB4 monoclonal antibod...

journal_title：Journal of cellular biochemistry

authors： Wright JT,Hausman GJ

更新日期：1991-03-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity. TRAIL is known to induce apoptosis in cancer cells but spare most normal cells. In the previous study [Yoo and Lee, 2007], we have reported that hyperthermia could enhance the cytot...

journal_title：Journal of cellular biochemistry

authors： Yoo J,Lee YJ

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence ...

journal_title：Journal of cellular biochemistry

authors： Li J,Liu R,Tang S,Feng F,Wang X,Qi L,Liu C,Yao Y,Sun C

更新日期：2018-11-28 00:00:00

abstract：:We have cloned and sequenced a genomic DNA fragment of chicken containing a cluster of DNase I hypersensitive sites (DHS) located 11-15 kb upstream from the first gene of the alpha-globin gene domain and including a constitutive DHS flanked by two erythroid-specific ones. A 1.2-kb subfragment of the DNA fragment under...

journal_title：Journal of cellular biochemistry

authors： Razin SV,Shen K,Ioudinkova E,Scherrer K

更新日期：1999-07-01 00:00:00

abstract：:The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes-induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule were prepared and administered p.o. to diabetic mice for 17 we...

journal_title：Journal of cellular biochemistry

authors： Yang X,Zhang P,Zhang F,Ke Z,Chen Q,Liu C

更新日期：2020-06-01 00:00:00

abstract：:Breast cancer cells preferentially metastasize to bone, leading to the formation of primarily osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of osteolytic bone metastases. An increase in the ratio of receptor activator of nuclear factor kappaB ligand (RANKL) to OPG increases os...

journal_title：Journal of cellular biochemistry

authors： Kapoor P,Suva LJ,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression o...

journal_title：Journal of cellular biochemistry

authors： Wang D,Wang H,Gao F,Wang K,Dong F

更新日期：2017-06-01 00:00:00

abstract：:Madin-Darby canine kidney (MDCK) cells were previously shown to have few or no plasma membrane insulin binding sites (Hofmann et al: J Biol Chem 258:11774, 1983]. Accordingly, neither insulin-stimulated incorporation of [14C]glucose into glycogen, nor insulin-induced uptake of radiolabeled alpha-aminoisobutyrate ([3H]...

journal_title：Journal of cellular biochemistry

authors： Hofmann C,Crettaz M,Bruns P,Hessel P,Hadawi G

更新日期：1985-01-01 00:00:00

abstract：:Using computer stress-induced duplex destabilization (SIDD) analysis and binding experiments, we identified a S/MAR element (-599/-200 bp) (Hp-S/MAR) adjacent to the cis-element (-165/-56 bp) in the rat haptoglobin gene. We examined its functional interactions with the lamins and lamin-associated proteins in the basal...

journal_title：Journal of cellular biochemistry

authors： Vidaković M,Dinić S,Grdović N,Mihailović M,Uskoković A,Quesada P,Poznanović G

更新日期：2009-08-15 00:00:00

abstract：:The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PT...

journal_title：Journal of cellular biochemistry

authors： Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen J

更新日期：2020-02-01 00:00:00