Abstract:
:Measurement of HIV viral load (VL) is the best indicator of success of antiretroviral therapy. We investigated the correlation between results by the Cepheid GeneXpert and a standard of care VL assay (Abbott M2000). This was a prospective study of people living with HIV who attended the department for routine VL measurement with the Abbott M2000. Consenting patients agreed to provide one extra blood sample for VL measurement with the Cepheid GeneXpert assay. One hundred patients consented to participate in the study. There were 18 patients with VL ≥ 40 copies/mL and 75 patients with VL < 40 copies on both assays. The two assays had 93% agreement, with a kappa of 0.79 (p < 0.001). Treating VL as a continuous variable found measurements to be significantly higher on the Cepheid GeneXpert assay than the Abbott (p = 0.002). Analysis of samples with VL ≥ 40 copies/mL on either assay (n = 25) found the mean difference between the two assays to be 0.31 log10 copies/mL (95% limits of agreement: -0.63, 1.25). Whilst the measurements on the two assays are relatively highly correlated, there is a clear bias, with the Cepheid GeneXpert tending to give higher VL values.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Manavi K,Hodson J,Masuka S,Singo M,Dedicoat K,Osman Hdoi
10.1177/0956462420975606subject
Has Abstractpub_date
2021-01-09 00:00:00pages
956462420975606eissn
0956-4624issn
1758-1052pub_type
杂志文章abstract::We describe a recent outbreak of syphilis in young heterosexuals in the north west of England. A cluster of 12 cases of syphilis (7 primary and 5 early latent) was identified in Rochdale in heterosexuals aged 20 or under. Nine were women. Five were asymptomatic at presentation. This outbreak occurred in a group not us...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011031
更新日期:2011-09-01 00:00:00
abstract::In a study to determine the significance of Bacteroides ureolyticus in the lower urogenital tract using a new selective and differential medium, this organism was isolated from 30.1% of asymptomatic men, 37.8% of men with genital warts, and 26.3% of men with non-gonococcal urethritis. Using the same selective medium B...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249200300206
更新日期:1992-03-01 00:00:00
abstract::Our objectives were to determine the prevalence of Neisseria gonorrhoeae not fully sensitive to ciprofloxacin from a sexually transmitted infection (STI) clinic in London and where the isolates were acquired from. Data of antibiotic sensitivities of N. gonorrhoeae from 292 patients were reviewed over a 6-month period ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001915264
更新日期:2000-12-01 00:00:00
abstract::From June to December 1990, 806 prostitutes registered with the STD programme in Singapore for regular screening for sexually transmitted diseases (STD) were investigated for factors associated with STD incidence in the preceding year. The majority were foreigners (92.7% Malaysians and 3.1% Thais). Anal sex (0.4%) and...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249200300506
更新日期:1992-09-01 00:00:00
abstract::This study examined the health risk profile of prostitutes in Dublin. Clinical records of all 150 new prostitutes who attended a drop-in clinic for prostitutes in Dublin city during the period 1991-1997 were reviewed. Variables examined included: age, use of injectable drugs, human immunodeficiency virus (HIV) status,...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981922557
更新日期:1998-08-01 00:00:00
abstract::Detection of Haemophilus ducreyi in genital ulcer specimens by culture lacks sensitivity. To enhance detection, a heminested polymerase chain reaction (PCR) assay was developed targeting the nucleotide sequence of a gene, designated p27, which encodes for a 27 kDa H. ducreyi-specific protein. The p27 PCR assay detecte...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011924425
更新日期:2001-12-01 00:00:00
abstract::This study looks at the sensitivity of microscopy in the diagnosis of Neisseria gonorrhoeae (NG), the effect of microscopy on time to treatment of NG and the added value of microscopy in the management of gonorrhoea. Women diagnosed with NG at an inner city genitourinary (GU) medicine clinic between August 2005 and Ju...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207782193876
更新日期:2007-10-01 00:00:00
abstract::Within the UK, the majority of hepatitis A occurs in high risk groups such as men who have sex with men (MSM). It has been estimated that 70% of MSM need immunity to provide adequate herd immunity. We aimed to estimate the proportion of hepatitis A susceptibility in MSM throughout a 10-year period (2010-2019), and exp...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420961960
更新日期:2020-12-18 00:00:00
abstract::Danish male military recruits (n = 388) were included in a follow-up study to investigate the prevalence and persistence of asymptomatic Chlamydia trachomatis infections. Urine specimens were collected at enrolment and after approximately six months. C. trachomatis was detected by polymerase chain reaction (Amplicor, ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646202762226100
更新日期:2002-12-01 00:00:00
abstract::In the Sexual Health Strategy, the targets of HIV testing uptake in genitourinary medicine clinics (GUM) are set at 40% by year 2004 and 60% by 2007. We assessed the uptake of HIV test amongst GUM clinic attendees, more than six months after introducing an information leaflet in place of verbal pre-test counselling (P...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204774195308
更新日期:2004-06-01 00:00:00
abstract::The management of cases of Chlamydia trachomatis genital infection diagnosed in clinics in Wessex in the last quarter of 1996 was surveyed, and the results compared with those obtained in the national gonorrhoea audit. Treatment regimens were extremely varied both between and within clinics. Overall, 71% of patients s...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921675
更新日期:1998-02-01 00:00:00
abstract::Since 2014, HIV care and treatment services among key populations including female sex workers (FSWs) have intensified in Tanzania. We sought to track the epidemic among FSWs in Dar es Salaam, Tanzania. We conducted a cross-sectional integrated bio-behavioral survey using respondent-driven sampling and a structured qu...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420917848
更新日期:2020-09-01 00:00:00
abstract::The prevalence of viral and bacterial sexually transmitted diseases were studied in 101 men attending a dermatovenereal outpatient clinic in Mogadishu. A control group of 103 healthy adult men were included for the serological part of the study. Serological markers of hepatitis B virus (HBV), human immunodeficiency vi...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100206
更新日期:1990-03-01 00:00:00
abstract::The current standard treatment for cerebral toxoplasmosis (pyrimethamine/sulfadiazine) often encounters problems of poor tolerability, adverse effects, frequent dropouts and non-availability of pyrimethamine/sulfadiazine in some parts of India. We have had to use the combination of two effective alternative agents for...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414560594
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to develop and evaluate a simple V3 peptide-based enzyme immunoassay (PEIA) for large-scale serotyping of HIV-1 specimens derived from injecting drug users (IDUs) in the Russian Federation. Two synthetic peptides were evaluated, named P1 (RKSIHIGPGRAFYATGD) and P2 (RTSVRIGPGQVFYKTGD), in an P...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::We aim to monitor the trends of antimicrobial resistance in Neisseria gonorrhoeae and to compare the results of antimicrobial sensitivity by disc diffusion and minimum inhibitory concentration (MIC). Two hundred and eleven confirmed strains of N. gonorrhoeae were subjected to antimicrobial sensitivity testing by disc ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646240001100209
更新日期:2000-02-01 00:00:00
abstract::A questionnaire survey and case notes audit reviewing management of epididymo-orchitis (E-O) by 34 Genitourinary Medicine (GUM) clinics located in the North Thames was undertaken. Twenty-two clinics (65%) returned completed questionnaires and audited a total of 83 newly diagnosed cases. All participating clinics offer...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011923066
更新日期:2001-05-01 00:00:00
abstract:SUMMARY:The objective of this study was to identify factors associated with (i) longer patient travel time to genitourinary (GU) medicine clinics and (ii) not attending the nearest clinic. Questionnaires were completed by 4600 new attendees from seven sociodemographically and geographically different GU clinics across ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008205
更新日期:2008-12-01 00:00:00
abstract::Progression of lipodystrophy syndrome is a big challenge in HIV treatment. Nowadays, fat loss at the lower part of buttocks has become another problem as patients have started to complain that it is painful to be seated for a long time and/or on hard surfaces. We developed a method for buttock lipoatrophy treatment wi...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414536878
更新日期:2015-03-01 00:00:00
abstract::Sexually transmitted diseases (STDs) interact uniquely with HIV infection, regardless of the form of sexual transmission of HIV. Both STDs and HIV infection are behaviorally and biologically intertwined with one another. This concept is called epidemiologic synergy since they facilitate the sexual transmission of on...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462961917735
更新日期:1996-01-01 00:00:00
abstract::The prevalence of gonorrhoea and urogenital chlamydial infection was investigated in female prostitutes in Tegucigalpa, Honduras. Epidemiological data were recorded according to a standardized questionnaire. The median age of the prostitutes was 27 years and the median period of prostitution was 2-4 years. Most of the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200309
更新日期:1991-05-01 00:00:00
abstract::To assess the efficacy of a novel glycosylated mammalian cell derived recombinant human interferon-beta (r-hIFN-beta-1a) in the intralesional treatment of genital condylomata acuminata. The study was randomized, double-blind and placebo-controlled. Patients (n=60) with up to 8 distinct condylomata acuminata were rando...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1258/0956462971918878
更新日期:1997-10-01 00:00:00
abstract::The distribution of prevalent HIV-1 strains are still complex in China. Men who have sex with men (MSM) play an important bridging role in spreading HIV. The aim of our study was to quantitatively evaluate the prevalence of HIV-1 subtypes among the MSM population in China from published studies. Relevant studies were ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0956462414543841
更新日期:2015-04-01 00:00:00
abstract::There is still a paucity of research on the sociodemographic and other underlying factors associated with HIV transmission among women in India. This study was designed to investigate such factors in sexually experienced Indian women. We used data from the National Family Health Survey 3 (NFHS-3), which tested 52,853 ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.010127
更新日期:2011-03-01 00:00:00
abstract::Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420964647
更新日期:2020-12-13 00:00:00
abstract::The British HIV Association (BHIVA) has published guidelines for immunization of HIV-infected adults. A chart review of 200 HIV-infected patients diagnosed was conducted to determine shortcomings in previous practice and determine which vaccines should routinely be given in specialist HIV clinics and which might be ab...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011231
更新日期:2012-02-01 00:00:00
abstract::The objective of this study was to audit the management of syphilis in our integrated sexual health clinic according to the British Association for Sexual Health and HIV (BASHH) guideline using the 'Treponemal Infection Care' (TIC) audit tool devised by our clinic. The case notes of patients diagnosed with all stages ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010392
更新日期:2011-05-01 00:00:00
abstract::Cytomegalovirus (CMV) colitis is a well recognized complication of advanced HIV disease and is only rarely diagnosed in patients with normal immune function. A case of CMV colitis occurring in early HIV infection is described. Although CMV infection is normally confined to patients with advanced HIV disease, it is pos...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001915183
更新日期:2000-11-01 00:00:00
abstract::Risk factors for HIV infection in partners of HIV-seropositive index cases were investigated in a cross-sectional survey. Between September 1992 and April 1994 a total of 251 HIV-infected persons and 76 of their sexual partners were interviewed at the main sexually transmitted diseases (STDs) clinic in Trinidad. All p...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921918
更新日期:1998-03-01 00:00:00
abstract::National guidelines state that hepatitis B and C testing should be targeted to those with risk factors. However, there is little data to support this recommendation. There is also limited data of viral hepatitis prevalence in attendees at genitourinary medicine clinics. We report the prevalence of hepatitis B infectio...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416641528
更新日期:2017-03-01 00:00:00