Abstract:
BACKGROUND:Clinicians and researchers synthesize data from randomized controlled trials (RCTs) of antidepressants to make conclusions about the efficacy of medications for depression. All treatments include nonspecific factors in addition to the specific effects of drugs, and study design may influence patient outcomes via nonspecific factors. This study investigated whether placebo control and treatment duration affect the outcome in antidepressant RCTs. METHODS:Medline and the Cochrane Database were searched to identify RCTs of antidepressants for major depression approved by the Food and Drug Administration. Included studies enrolled outpatient participants aged 18-65, lasted 6-12 weeks, compared an antidepressant to placebo or another antidepressant and were published in English after 1985. Excluded trials enrolled inpatients, pregnant women and subjects with psychosis or mania. Mixed-effects logistic regression models including study type (placebo-controlled or comparator) and study duration (6, 8 or 12 weeks) as fixed effects determined whether these factors affected response and remission rates. RESULTS:In the 90 trials analyzed, the odds of depression response (OR = 1.79, 95% CI = 1.45-2.17, p < 0.001) and remission (OR 1.53, 95% CI = 1.11-2.11, p < 0.001) were significantly higher in comparator relative to placebo-controlled trials. Trials lasting 8 (OR = 1.37, CI = 1.14-1.64, p = 0.001) and 12 (OR = 1.52, CI = 1.12-2.07, p = 0.008) weeks had significantly greater response rates than 6-week trials without differing themselves. CONCLUSIONS:Response and remission rates to antidepressants are significantly affected by study type and duration. Clinicians and researchers must consider the study design when interpreting and designing RCTs of antidepressant medications.
journal_name
Psychother Psychosomjournal_title
Psychotherapy and psychosomaticsauthors
Rutherford BR,Sneed JR,Roose SPdoi
10.1159/000209348subject
Has Abstractpub_date
2009-01-01 00:00:00pages
172-81issue
3eissn
0033-3190issn
1423-0348pii
000209348journal_volume
78pub_type
杂志文章abstract::Many child and adolescent psychotherapists are asked to work in specialized institutions (where the children are either interns or externs), with children presenting behaviour problems, learning difficulties, mental handicap or important psychosocial problems. They learn through diverse treatment forms, or parent acco...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288344
更新日期:1990-01-01 00:00:00
abstract::Compliance is an ancient topic subjected to intense recent scrutiny as a result of scientific and social changes which focus on lifestyle adjustment to chronic illness and emphasize increasing patient involvement in self-care. Difficulties in definition, measurement and research design as well as the complexity of the...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288624
更新日期:1992-01-01 00:00:00
abstract::The relationship between depressed mood and alexithymia, measured by the Toronto Alexithymia Scale (TAS) was investigated in a group of psychiatric inpatients (n = 81) and outpatients (n = 97). In both cohorts correlations between the TAS and obsessoid personality style were significant when controlled for mood. The o...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288373
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Parent-child treatments have been shown to be superior to child-focused treatments of childhood obesity. Yet until now, the comparative effectiveness of parent-only and parent-child approaches has been little studied. METHOD:Fifty-six obese children and their families were randomly assigned to a 16-session ...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000129659
更新日期:2008-01-01 00:00:00
abstract::It used to be fashionable to begin consideration of psychosomatics about philosophy of mind and body. Nowadays it is a topic about health and practical care of patients--principally about the psychological aspects of any illness. Pathogenesis is becoming understood with some risk factors clearly identifiable. The high...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288009
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the clinical features of psychosomatic disorders in Japan. METHODS:A total of 1,432 outpatients (515 males and 917 females; 9-95 years of age, mean age 36) attending a psychosomatic clinic for the first time were assessed by the DSM-III-R or DSM-IV semistructured int...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000012258
更新日期:1998-01-01 00:00:00
abstract::Given the contradictory reports concerning psychophysiological reactivity of hypertensives this issue was reexamined. In contrast to the large majority of studies, the hypertensive sample should not be made up of patients in medical care and the control group should be comparable in all relevant aspects other than blo...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288936
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Scarce data are available on the influence of psychological aspects on 24-hour ambulatory blood pressure patterns either in normotensive or hypertensive subjects. This study was designed to evaluate the relationship between psychological profile and changes in daytime/nighttime blood pressure rhythm. METHOD...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000065996
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Except for 3 case reports of Conn's syndrome presenting as depression, psychosocial factors have not been explored in primary aldosteronism. We investigated psychological correlates in primary aldosteronism using methods that were found to be sensitive and reliable in psychosomatic research. METHOD:Ten cons...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000093956
更新日期:2006-01-01 00:00:00
abstract::The political or ecological concept of quality of life refers to irreplaceable aspects of life. The health-related quality of life concept has the same impact of considering the irreplaceable (idiographic) aspects of treatment outcome in patients with chronic disorders. When comparing the different attempts to measure...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288637
更新日期:1993-01-01 00:00:00
abstract::Psychiatric clinicians frequently prescribe biologic treatments such as antidepressant medication in combination with psychologic treatments such as psychotherapy. In the present article we propose a model integrating antidepressant treatment with Beck's cognitive therapy, a form of psychotherapy with established effi...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288892
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Somatic illness and its consequences evoke strong emotions of various kinds. They may affect the course of illness and the treatment results through their physiological components. The purpose of the study was to explore emotional reactions to different kinds of illnesses and changes of these emotions over t...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000012348
更新日期:1999-01-01 00:00:00
abstract::The introduction of DSM-III/DSM-III-R and ICD-10 implies fundamental innovations to the diagnostic process. The changes relate both to formal aspects (e.g. symptom and time-related criteria) and to content (e.g. the abandonment of the concept of neurosis). Additionally, specific assessment instruments are introduced. ...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000288944
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Depression is one of the most frequent and costly mental disorders. While there is increasing evidence for the efficacy of online self-help to improve depression or prevent relapse, there is little evidence in blended care settings, especially combined with inpatient face-to-face psychotherapy. Therefore, we...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000481177
更新日期:2017-01-01 00:00:00
abstract::Recognition of the body-mind dilemma goes back to antiquity. Growth in medical knowledge has produced an ever increasing emphasis on physiological deviations and somatic pathology--which too often is not accompanied by sufficient attention to the total patients. Psychosomatics is now the term often used by those who b...
journal_title:Psychotherapy and psychosomatics
pub_type: 历史文章,杂志文章
doi:10.1159/000287311
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Many antidepressant medications (ADM) are associated with disruptions in sleep continuity that can compromise medication adherence and impede successful treatment. The present study investigated whether mindfulness meditation (MM) training could improve self-reported and objectively measured polysomnographic...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1159/000332755
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study is to compare the psychosomatic symptoms of postmenopausal women who are users of hormonal treatment with the psychosomatic symptoms of nonusers. We studied 68 postmenopausal women receiving estrogen treatment (age range 48-56 years; 51.1 +/- 1.9, mean +/- SD) and 50 postmenopausal women (age...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287971
更新日期:1986-01-01 00:00:00
abstract::In this article the results of a study to determine the degree of somatopsychic vulnerability in children with encopresis are discussed. A checklist was constructed for the registration of somatic and functional data relevant to encopresis. Twenty-five children with encopresis were compared with a control group. The e...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000286894
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Stress reduction and comprehensive lifestyle modification programs have improved atherosclerosis and cardiac risk factors in earlier trials. Little is known about the impact of such programs on quality-of-life (QoL) and psychological outcomes. Given recent significant improvements in cardiac care, we evaluat...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000087781
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Electromagnetic hypersensitivity (EHS) is a poorly understood condition in which patients report symptoms following perceived exposure to weak electromagnetic fields (EMFs) such as those produced by mobile phones or visual display units. Little is known about the aetiology of the condition although experimen...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章,评审
doi:10.1159/000089222
更新日期:2006-01-01 00:00:00
abstract::A psychometric analysis on patients with duodenal ulcer using latent structure coefficients (Loevinger and Mokken) showed that the MMPI subscales of depression, psychasthenia, hypochondriasis, hysteria, schizophrenia and social introversion all could be considered as indicators of Eysenck's dimension of neuroticism. B...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288919
更新日期:1994-01-01 00:00:00
abstract::The relation between personality characteristics and body awareness, defined as the attention paid to different body zones and measured by means of the Fisher Body Focus Questionnaire, is examined in two ways in groups of medical and dental students: (1) Our results replicate fairly well the relation, reported by Fish...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287385
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Psychiatric disorders are frequent in dermatology patients, and many studies pointed out complex, mutual relationships between psyche and skin. Our aim was to provide a systematic psychosocial evaluation of a large and heterogeneous population of patients with skin diseases, including assessments of quality ...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000086323
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Increasing attention has been given to the transparency of potential conflicts of interest in clinical medicine and biomedical sciences, particularly in journal publishing and science advisory panels. The authors examined the degree and type of financial ties to the pharmaceutical industry of panel members r...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000091772
更新日期:2006-01-01 00:00:00
abstract::In order to compare hypochondriacal phenomena in patients with generalized anxiety disorder (GAD) and panic disorder (PD), and in order to examine the relationship between worries about illness on one hand, and disease fears/phobias and hypochondriacal beliefs on the other, the authors administered the Illness Attitud...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000288873
更新日期:1994-01-01 00:00:00
abstract::In a small pilot controlled study over 8 weeks, 12 obsessive-compulsive ruminators listened for 2 h daily to their own audiotaped voice either (1) describing their anxiogenic thoughts (exposure) but omitting anxiolytic thoughts (mental/cognitive rituals), or (2) reading neutral prose or poetry. Taking all patients, bo...
journal_title:Psychotherapy and psychosomatics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000288883
更新日期:1994-01-01 00:00:00
abstract::In the present study of 253 patients with chronic pain syndrome we have made a multidimensional approach. All patients have been included in the study independent of coexisting states of anxiety or depression. We included criteria for diagnosis, duration, generability and intensity of pain, anxiety and depression, psy...
journal_title:Psychotherapy and psychosomatics
pub_type: 临床试验,杂志文章
doi:10.1159/000288032
更新日期:1987-01-01 00:00:00
abstract::114 patients with permanent colostomy for carcinoma of the rectum were compared by questionnaire and interview with 110 cancer patients, having undergone colonic resection but not bearing a colostomy. The patients' own assessment of their health was for the colostomy group even better than for the controls. The emotio...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000286938
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:: Previous studies of cancer patients investigated the effect of psychological treatment on basal endocrine and immune values. Using a randomized experiment, we explored the effect of a 13-week experiential-existential group psychotherapy (EEGP) program on the reactivity to a speech task in breast cancer pat...
journal_title:Psychotherapy and psychosomatics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000056271
更新日期:2001-11-01 00:00:00
abstract::Adolescents are frequently entangled in a web of transitions during their developmental journey from child to adult. These modulations include physiological and psychological changes: individual, familial and social readjustments, and alterations in the evolving family group. Psychosomatic manifestations are often tar...
journal_title:Psychotherapy and psychosomatics
pub_type: 杂志文章
doi:10.1159/000287421
更新日期:1980-01-01 00:00:00