Inhibition of phagocyte chemotaxis by uteroglobin, an inhibitor of blastocyst rejection.

Abstract:

:Uteroglobin, a steroid-dependent secretory protein first discovered in the rabbit uterus during early pregnancy, is a potent phospholipase A2 inhibitor. We found that uteroglobin also inhibited human and rabbit phagocyte chemotaxis in response to formyl peptide attractants in a dose-dependent manner. Half-maximal inhibition was at 1.2 microM. Uteroglobin did not compete with a formyl peptide for its receptor but inhibited internalization of radiolabeled formyl peptide. Uteroglobin appears to inhibit chemotaxis by a mechanism different from that of dansylcadaverine, a well studied inhibitor of endocytosis. Unlike dansylcadaverine, uteroglobin did not have any effect upon the synthesis of phosphatidylcholine or phosphatidylinositol. It is suggested that uteroglobin may protect trophoblastic cells from the defense system of the host not only by binding to antigenic determinants of embryonic cells but also by impairing migration of phagocytes, one of the primary components of the immune defense system. These results may explain why embryonic cells do not elicit an inflammatory response in the uterine endometrium during pregnancy.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Vasanthakumar G,Manjunath R,Mukherjee AB,Warabi H,Schiffmann E

doi

10.1016/0006-2952(88)90204-3

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

389-94

issue

3

eissn

0006-2952

issn

1873-2968

pii

0006-2952(88)90204-3

journal_volume

37

pub_type

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