Abstract：
:The ecotoxicity of binary chemical mixtures with a common mode of action is often predicted with the concentration addition model. The assumption of concentration addition is commonly tested statistically based on results of toxicity experiments with the two single chemicals and their binary mixture. The present simulation study shows that if not all these experiments are performed simultaneously, one has a 20-80% chance of concluding synergism or antagonism while the mixture is actually additive (false positive rate). Truly synergistic or antagonistic mixtures have a 10-50% chance of being falsely categorized as additive (false negative rate). Additionally, false positive rates decrease with increasing experimental error, while false negative rates increase with increasing experimental error. Based on these results, we put forward a number of recommendations for future mixture ecotoxicity evaluation.
journal_name
Chemospherejournal_title
Chemosphereauthors
De Laender F,Janssen CR,De Schamphelaere KAdoi
10.1016/j.chemosphere.2009.03.027subject
Has Abstractpub_date
2009-07-01 00:00:00pages
428-32issue
3eissn
0045-6535issn
1879-1298pii
S0045-6535(09)00326-9journal_volume
76pub_type
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