Abstract:
:Many Gram-negative bacterial pathogens use type III secretion systems (TTSSs) for subverting the normal cellular functions of their target eukaryotic cells. The type III secretion apparatus (TTSA) functions like a syringe to inject proteins through an external needle and into a target cell's membrane and cytosol. The TTSA basal body spans the bacterial inner and outer membranes, and the external needle is topped with a tip complex that controls the secretion and delivery of translocator and effector proteins. Recently solved structures of TTSA proteins have greatly advanced our understanding of shared themes in apparatus assembly and function. In this highlight, the structure-function of TTSA needle and tip complex proteins are described and common themes discussed.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Wang Y,Zhang L,Picking WL,Picking WD,De Guzman RNdoi
10.1039/b808271psubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1176-80issue
12eissn
1742-206Xissn
1742-2051journal_volume
4pub_type
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