Comorbidity and severity-of-illness risk adjustment for hospital-onset Clostridioides difficile infection using data from the electronic medical record.

Abstract:

OBJECTIVE:To determine whether electronically available comorbidities and laboratory values on admission are risk factors for hospital-onset Clostridioides difficile infection (HO-CDI) across multiple institutions and whether they could be used to improve risk adjustment. PATIENTS:All patients at least 18 years of age admitted to 3 hospitals in Maryland between January 1, 2016, and January 1, 2018. METHODS:Comorbid conditions were assigned using the Elixhauser comorbidity index. Multivariable log-binomial regression was conducted for each hospital using significant covariates (P < .10) in a bivariate analysis. Standardized infection ratios (SIRs) were computed using current Centers for Disease Control and Prevention (CDC) risk adjustment methodology and with the addition of Elixhauser score and individual comorbidities. RESULTS:At hospital 1, 314 of 48,057 patient admissions (0.65%) had a HO-CDI; 41 of 8,791 patient admissions (0.47%) at community hospital 2 had a HO-CDI; and 75 of 29,211 patient admissions (0.26%) at community hospital 3 had a HO-CDI. In multivariable regression, Elixhauser score was a significant risk factor for HO-CDI at all hospitals when controlling for age, antibiotic use, and antacid use. Abnormal leukocyte level at hospital admission was a significant risk factor at hospital 1 and hospital 2. When Elixhauser score was included in the risk adjustment model, it was statistically significant (P < .01). Compared with the current CDC SIR methodology, the SIR of hospital 1 decreased by 2%, whereas the SIRs of hospitals 2 and 3 increased by 2% and 6%, respectively, but the rankings did not change. CONCLUSIONS:Electronically available patient comorbidities are important risk factors for HO-CDI and may improve risk-adjustment methodology.

authors

Cabral SM,Goodman KE,Blanco N,Leekha S,Magder LS,Nadimpalli G,Pineles L,Thom KA,Harris AD

doi

10.1017/ice.2020.1344

subject

Has Abstract

pub_date

2020-12-17 00:00:00

pages

1-7

eissn

0899-823X

issn

1559-6834

pii

S0899823X20013446

pub_type

杂志文章
  • Simulated-Use Polytetrafluorethylene Biofilm Model: Repeated Rounds of Complete Reprocessing Lead to Accumulation of Organic Debris and Viable Bacteria.

    abstract::OBJECTIVE Biofilm has been implicated in bacterial persistence and survival after endoscope reprocessing. In this study, we assessed the impact of different methods of reprocessing on organic residues and viable bacteria after repeated rounds of biofilm formation when each was followed by full reprocessing. METHODS AT...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2017.215

    authors: Alfa MJ,Singh H,Nugent Z,Duerksen D,Schultz G,Reidy C,DeGagne P,Olson N

    更新日期:2017-11-01 00:00:00

  • The use of best practice alerts with the development of an antimicrobial stewardship navigator to promote antibiotic de-escalation in the electronic medical record.

    abstract:OBJECTIVE:Develop a clinical decision support tool comprised of an electronic medical record alert and antimicrobial stewardship navigator to facilitate antimicrobial stewardship. DESIGN:We analyzed alerts targeting antimicrobial de-escalation to assess the effectiveness of the navigator as a stewardship tool. The ale...

    journal_title:Infection control and hospital epidemiology

    pub_type: 临床试验,杂志文章

    doi:10.1086/673977

    authors: Schulz L,Osterby K,Fox B

    更新日期:2013-12-01 00:00:00

  • Optimum outlier model for potential improvement of environmental cleaning and disinfection.

    abstract::The effectiveness and efficiency of 17 housekeepers in terminal cleaning 292 hospital rooms was evaluated through adenosine triphosphate detection. A subgroup of housekeepers was identified who were significantly more effective and efficient than their coworkers. These optimum outliers may be used in performance impro...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/676431

    authors: Rupp ME,Huerta T,Cavalieri RJ,Lyden E,Van Schooneveld T,Carling P,Smith PW

    更新日期:2014-06-01 00:00:00

  • Variation in definitions and isolation procedures for multidrug-resistant Gram-negative bacteria: a survey of the Society for Healthcare Epidemiology of America Research Network.

    abstract:OBJECTIVE:To assess definitions, experience, and infection control practices for multidrug-resistant gram-negative bacteria (MDR-GNB), including Enterobacteriaceae, Acinetobacter, and Pseudomonas species, in acute care hospitals. DESIGN:Cross-sectional survey. PARTICIPANTS:US and international members of the Society ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/675600

    authors: Drees M,Pineles L,Harris AD,Morgan DJ

    更新日期:2014-04-01 00:00:00

  • Chasing the rate: An interrupted time series analysis of interventions targeting reported hospital onset Clostridioides difficile, 2013-2018.

    abstract:OBJECTIVE:To assess the impact of major interventions targeting infection control and diagnostic stewardship in efforts to decrease Clostridioides difficile hospital onset rates over a 6-year period. DESIGN:Interrupted time series. SETTING:The study was conducted in an 865-bed academic medical center. METHODS:Monthl...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2020.247

    authors: Doll ME,Zhao J,Kang L,Rittmann B,Alvarez M,Fleming M,Cooper K,Stevens MP,Bearman G

    更新日期:2020-10-01 00:00:00

  • Failure of bland soap handwash to prevent hand transfer of patient bacteria to urethral catheters.

    abstract:OBJECTIVE:The study was designed to compare the efficacies of bland soap handwash and isopropyl alcohol hand rinse in preventing transfer of aerobic gram-negative bacilli to urinary catheters via transient hand colonization acquired from direct patient contact. Glove juice recovery of gram-negative bacteria was conside...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646261

    authors: Ehrenkranz NJ,Alfonso BC

    更新日期:1991-11-01 00:00:00

  • Days of Therapy and Antimicrobial Days: Similarities and Differences Between Consumption Metrics.

    abstract::Benchmarks for antimicrobial consumption measured in antimicrobial days are beginning to emerge. The relationship between the traditional measure of days of therapy and antimicrobial days is unclear. We observed a high intermethod correlation (R2=0.99): antimicrobial days were 1.9-fold lower than days of therapy acros...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2016.109

    authors: Rhodes NJ,Wagner JL,Gilbert EM,Crew PE,Davis SL,Scheetz MH

    更新日期:2016-08-01 00:00:00

  • Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection.

    abstract::In this prospective study, we monitored 4 epidemiologically important pathogens (EIPs): methicillin-resistane Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Clostridium difficile, and multidrug-resistant (MDR) Acinetobacter to assess the effectiveness of 3 enhanced disinfection strategies for te...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1017/ice.2018.165

    authors: Rutala WA,Kanamori H,Gergen MF,Knelson LP,Sickbert-Bennett EE,Chen LF,Anderson DJ,Sexton DJ,Weber DJ,and the CDC Prevention Epicenters Program.

    更新日期:2018-09-01 00:00:00

  • Topical therapy for methicillin-resistant Staphylococcus aureus colonization: impact on infection risk.

    abstract:OBJECTIVE:We evaluated the usefulness of topical decolonization therapy for reducing the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection among MRSA-colonized inpatients. DESIGN:Retrospective cohort study. SETTING AND INTERVENTION:Three hospitals with universal surveillance for MRSA; at their phys...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/597550

    authors: Robicsek A,Beaumont JL,Thomson RB Jr,Govindarajan G,Peterson LR

    更新日期:2009-07-01 00:00:00

  • Expanding roles of healthcare epidemiology and infection control in spite of limited resources and compensation.

    abstract:OBJECTIVE:Data on the resources and staff compensation of hospital epidemiology and infection control (HEIC) departments are limited and do not reflect current roles and responsibilities, including the public reporting of healthcare-associated infections. This study aimed to obtain information to assist HEIC profession...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/650199

    authors: Wright SB,Ostrowsky B,Fishman N,Deloney VM,Mermel L,Perl TM

    更新日期:2010-02-01 00:00:00

  • Implementation Lessons Learned From the Benefits of Enhanced Terminal Room (BETR) Disinfection Study: Process and Perceptions of Enhanced Disinfection with Ultraviolet Disinfection Devices.

    abstract::OBJECTIVE To summarize and discuss logistic and administrative challenges we encountered during the Benefits of Enhanced Terminal Room (BETR) Disinfection Study and lessons learned that are pertinent to future utilization of ultraviolet (UV) disinfection devices in other hospitals DESIGN Multicenter cluster randomized...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1017/ice.2017.268

    authors: Anderson DJ,Knelson LP,Moehring RW,Lewis SS,Weber DJ,Chen LF,Triplett PF,Blocker M,Cooney RM,Schwab JC,Lokhnygina Y,Rutala WA,Sexton DJ,CDC Prevention Epicenters Program.

    更新日期:2018-02-01 00:00:00

  • Adverse exposures and universal precautions practices among a group of highly exposed health professionals.

    abstract::An anonymous national survey of a representative population of healthcare workers who were thought likely to have frequent and intensive exposures to blood and other body fluids (certified nurse-midwives [CNMs]), was conducted to assess the type and frequency of self-reported occupational exposures to blood and body f...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646186

    authors: Willy ME,Dhillon GL,Loewen NL,Wesley RA,Henderson DK

    更新日期:1990-07-01 00:00:00

  • Biological warfare and infection control.

    abstract::Though many agents have been proposed as potential biological weapons, the feasibility of biological warfare is largely a matter of conjecture. The unpredictable and indiscriminate devastation caused by natural epidemics during wartime should warn us of the dangers of employing microbes as weapons. ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 历史文章,杂志文章

    doi:10.1086/646358

    authors: Nettleman MD

    更新日期:1991-06-01 00:00:00

  • Vancomycin use in a hospital with vancomycin restriction.

    abstract::We evaluated vancomycin use in a hospital with endemic vancomycin-resistant enterococci and a vancomycin restriction program. Only 68% of vancomycin was prescribed appropriately. Inappropriate use was due primarily to empirical therapy. In the patients with a microbiological diagnosis following empirical therapy, 83% ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/501548

    authors: Roghmann MC,Perdue BE,Polish L

    更新日期:1999-01-01 00:00:00

  • Epidemiology of Acinetobacter baumannii in a university hospital in Turkey.

    abstract:OBJECTIVE:Molecular epidemiologic surveillance of Acinetobacter baumannii by polymerase chain reaction-randomly amplified polymorphic DNA analysis in a university hospital for 3 consecutive study periods. RESULTS:Twelve different Acinetobacter baumannii genotypes (A-L) were detected. Although only 2 genotypes were det...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/503349

    authors: Akalin H,Ozakin C,Gedikoglu S

    更新日期:2006-04-01 00:00:00

  • Clostridium difficile Exposures, Colonization, and the Microbiome: Implications for Prevention.

    abstract::New studies have been published regarding the epidemiology of Clostridium difficile in topics such as asymptomatic C. difficile colonization, community-associated C. difficile infection, environmental contamination outside healthcare settings, animal colonization, and the interactions between C. difficile and the gut ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审

    doi:10.1017/ice.2018.36

    authors: Revolinski SL,Munoz-Price LS

    更新日期:2018-05-01 00:00:00

  • Evaluation of the New Centers for Disease Control and Prevention Ventilator-Associated Event Module and Criteria in Critically Ill Children in Greece.

    abstract::OBJECTIVE To evaluate the new adult Centers for Disease Control and Prevention (CDC) ventilator-associated event (VAE) module in critically ill children and compare with the traditionally used CDC definition for ventilator-associated pneumonia (VAP). DESIGN Retrospective observational study of mechanically ventilated ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2016.135

    authors: Iosifidis E,Chochliourou E,Violaki A,Chorafa E,Psachna S,Roumpou A,Sdougka M,Roilides E

    更新日期:2016-10-01 00:00:00

  • Frequency of Hand Decontamination of Intraoperative Providers and Reduction of Postoperative Healthcare-Associated Infections: A Randomized Clinical Trial of a Novel Hand Hygiene System.

    abstract::BACKGROUND Healthcare provider hands are an important source of intraoperative bacterial transmission events associated with postoperative infection development. OBJECTIVE To explore the efficacy of a novel hand hygiene improvement system leveraging provider proximity and individual and group performance feedback in r...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/ice.2016.106

    authors: Koff MD,Brown JR,Marshall EJ,O'Malley AJ,Jensen JT,Heard SO,Longtine K,O'Neill M,Longtine J,Houston D,Robison C,Moulton E,Patel HM,Loftus RW

    更新日期:2016-08-01 00:00:00

  • The influenza vaccination demonstration project: an expanded policy goal.

    abstract::In 1980, the Public Health Service established an objective of immunizing 60% of high-risk persons with influenza vaccine annually by the year 1990. As no more than 32% of high-risk persons currently receive influenza vaccine each year, the Health Care Financing Administration (HCFA) has undertaken an influenza vaccin...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646187

    authors: Fedson DS

    更新日期:1990-07-01 00:00:00

  • Nosocomial infection after septic shock among intensive care unit patients.

    abstract:OBJECTIVES:To measure the incidence of nosocomial infection (NI) among patients with septic shock according to the place of septic shock acquisition and to evaluate the increase in the risk of pulmonary infection associated with septic shock. DESIGN:Prospective cohort study. SETTING:Two intensive care units (ICUs) of...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/591859

    authors: Landelle C,Lepape A,Français A,Tognet E,Thizy H,Voirin N,Timsit JF,Monneret G,Vanhems P

    更新日期:2008-11-01 00:00:00

  • Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting.

    abstract:OBJECTIVE:To determine whether hydrogen peroxide vapor (HPV) decontamination can reduce environmental contamination with and nosocomial transmission of Clostridium difficile. DESIGN:A prospective before-after intervention study. SETTING:A hospital affected by an epidemic strain of C. difficile. INTERVENTION:Intensiv...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/589906

    authors: Boyce JM,Havill NL,Otter JA,McDonald LC,Adams NM,Cooper T,Thompson A,Wiggs L,Killgore G,Tauman A,Noble-Wang J

    更新日期:2008-08-01 00:00:00

  • Reduction in tuberculin skin-test conversion rate after improved adherence to tuberculosis isolation.

    abstract::The rate of purified protein derivative (PPD) conversion in workers at our hospital increased to 1.7% in 1991. After implementation of mandatory respiratory isolation of patients with community-acquired pneumonia, the rate dropped to 0.6%. This policy may protect workers in institutions where the majority of patients ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647675

    authors: Uyamadu N,Ahkee S,Carrico R,Tolentino A,Wojda B,Ramirez J

    更新日期:1997-08-01 00:00:00

  • Economic analysis of reprocessing single-use medical devices: a systematic literature review.

    abstract:BACKGROUND:Although an increasing number of medical devices are labeled "for single use only," cleaning and reuse of single-use medical devices continues, because of the economic incentive. We conducted a survey of the economic literature to obtain the current evidence available and to assess the costs and benefits of ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审

    doi:10.1086/529587

    authors: Jacobs P,Polisena J,Hailey D,Lafferty S

    更新日期:2008-04-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.

    abstract::We investigated a cluster of methicillin-resistant Staphylococcus aureus infections in college football players. Risk factors included a history of recurrent skin infections and contact with the skin lesions of persons outside college. The infections were controlled through treatment of carriers with topical mupirocin...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/587971

    authors: Archibald LK,Shapiro J,Pass A,Rand K,Southwick F

    更新日期:2008-05-01 00:00:00

  • Medical errors detected and corrected by a pediatric infectious diseases consultation service.

    abstract::Errors occur frequently in healthcare and can adversely affect outcomes. This prospective study demonstrates that pediatric consultants can detect a broad range of errors in the course of routine work. Many of these errors have the potential to cause harm and can be corrected by the intervention of an infectious disea...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/502561

    authors: Sandora TJ,Goldmann DA

    更新日期:2005-04-01 00:00:00

  • Epidemiologic approaches to quality assessment.

    abstract::Hospital epidemiologists have an opportunity to apply their skills to hospital quality problems other than infection control. Soon, hospitals will be required to collect and report numerous quality indicators, whose results will require epidemiologic interpretation. For those who choose to make the transition into qua...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/647065

    authors: Simmons BP,Kritchevsky SB

    更新日期:1995-02-01 00:00:00

  • Strategies for the management of varicella-susceptible healthcare workers after a known exposure.

    abstract::Three different sequentially applied post-varicella zoster virus (VZV) exposure management strategies were employed over a 43-month period. We began by using a standard post-exposure protocol in which 50 susceptible healthcare workers (HCW) involved in hospital exposures were furloughed from work at a loss to the hosp...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646176

    authors: Josephson A,Karanfil L,Gombert ME

    更新日期:1990-06-01 00:00:00

  • Acquisition of Clostridium difficile on Hands of Healthcare Personnel Caring for Patients with Resolved C. difficile Infection.

    abstract::In an observational study, we found that healthcare personnel frequently acquired Clostridium difficile on their hands when caring for patients with recently resolved C. difficile infection (CDI) (<6 weeks after treatment) who were no longer under contact precautions. Continuing contact precautions after diarrhea reso...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1017/ice.2015.335

    authors: Shrestha SK,Sunkesula VC,Kundrapu S,Tomas ME,Nerandzic MM,Donskey CJ

    更新日期:2016-04-01 00:00:00

  • Evaluation of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for reporting methicillin-resistant Staphylococcus aureus infections at a hospital in Illinois.

    abstract:BACKGROUND:States, including Illinois, have passed legislation mandating the use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for reporting healthcare-associated infections, such as methicillin-resistant Staphylococcus aureus (MRSA). OBJECTIVE:To evaluate the sens...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/651665

    authors: Schaefer MK,Ellingson K,Conover C,Genisca AE,Currie D,Esposito T,Panttila L,Ruestow P,Martin K,Cronin D,Costello M,Sokalski S,Fridkin S,Srinivasan A

    更新日期:2010-05-01 00:00:00

  • Inactivation of human immunodeficiency virus by a medical waste disposal process using chlorine dioxide.

    abstract:OBJECTIVE:To study the ability of a medical waste disposal process using chlorine dioxide to inactivate human immunodeficiency virus type 1 (HIV-1). DESIGN:Stock HIV-1 (HTLV-IIIB strain) was treated with chlorine dioxide under the following settings: cell culture medium alone, culture medium with 25% blood, culture me...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章

    doi:10.1086/646798

    authors: Farr RW,Walton C

    更新日期:1993-09-01 00:00:00