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The application of solvent-processed human dura in experimental tracheal reconstruction.

Abstract：

:To evaluate the role of solvent-processed human cadaveric dura in experimental tracheal reconstruction, anesthetized piglets underwent an elliptical excision of a four-ring segment of the trachea. Twelve animals were randomly divided into two equal groups: in group I, the resected trachea was rotated 180 degrees and sutured into position; in group II, the resected trachea was replaced with dura. The animals were extubated after the operation, and endotracheal stents were not used. Tracheal dimensions were recorded, and tissues were evaluated for mechanical compliance (percent elongation/displacement). Histology of the grafts was characterized by fibrosis and granulation tissue, and there were no distinguishing features between groups. The data suggest that solvent-processed human dura has compliance and patency comparable to those of autologous free-grafted trachea and that it may prove useful as an adjunct to reconstructive tracheal surgery in infants.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Lobe TE,Gore DC,Linares H,Tencer A

doi

10.1016/0022-3468(91)90683-k

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

1104-6

issue

9

eissn

0022-3468

issn

1531-5037

pii

0022-3468(91)90683-K

journal_volume

26

pub_type

杂志文章

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