Gastric emptying in health and type 2 diabetes: An evaluation using a 75 g oral glucose drink.

Abstract:

AIM:Gastric emptying is a major determinant of the glycaemic response to carbohydrate and is frequently abnormal in type 2 diabetes (T2DM). There is little information about how chronic glycaemic control affects gastric emptying in T2DM. We evaluated gastric emptying of a 75 g glucose drink in community-based patients with T2DM of short duration with good or poor glycaemic control, and compared this to young and older controls. METHODS:T2DM patients managed by diet and/or metformin, either well-controlled or poorly-controlled, together with young and age-matched older controls without diabetes, consumed a 75 g oral glucose drink containing 150 mg 13C-acetate for evaluation of gastric emptying (breath test) and blood glucose over 180 min. RESULTS:The gastric half-emptying time (T50) was longer in the older than the young non-diabetic subjects (P = 0.041), but shorter in well-controlled T2DM patients than age-matched older controls (P = 0.043). The T50 in poorly-controlled T2DM patients was shorter than in older controls (P = 0.006), but similar to young non-diabetic subjects. CONCLUSIONS:Gastric emptying of a glucose drink is delayed with ageing, but more rapid in patients with T2DM of relatively short duration, regardless of their glycaemic status. These observations support interventions that slow gastric emptying to improve postprandial glycaemia in these patients with T2DM.

authors

Xie C,Huang W,Wang X,Trahair LG,Pham HT,Marathe CS,Young RL,Jones KL,Horowitz M,Rayner CK,Wu T

doi

10.1016/j.diabres.2020.108610

subject

Has Abstract

pub_date

2020-12-07 00:00:00

pages

108610

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(20)30867-6

journal_volume

171

pub_type

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