Expression of the orphan nuclear receptor NR4A in a putative adenohypophyseal homologue of amphioxus.

abstract：:Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to...

journal_title：Annals of the New York Academy of Sciences

authors： Jabbi M,Korf J,Ormel J,Kema IP,den Boer JA

更新日期：2008-12-01 00:00:00

abstract：:The thymus produces several putative thymic hormones: thymosin alpha 1, thymulin, and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T cells in the periphery, thus maintaining their commitment to the T cell system. These endocrine influences decline with age and are ass...

journal_title：Annals of the New York Academy of Sciences

authors： Hadden JW,Malec PH,Coto J,Hadden EM

更新日期：1992-12-26 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:A diagnostic test is particularly beneficial if it reveals the level of susceptibility prior to onset of a disease process. In the case of childhood caries, such a diagnostic test affords the opportunity for preventive measures to be implemented before caries begins. Salivary glycoproteins contain a wealth of individu...

journal_title：Annals of the New York Academy of Sciences

authors： Denny PC,Denny PA,Takashima J,Galligan J,Navazesh M

更新日期：2007-03-01 00:00:00

abstract：:Experimental Herpesvirus hominis encephalitis in 3-week-old Swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-A), phosphonacetic acid (PAA), and humoral antibodies to H. hominis (HIG). Administration of ara-A, PAA, or HIG during the early phase of infection reduced the mortality rat...

journal_title：Annals of the New York Academy of Sciences

authors： Cho CT,Feng KK

更新日期：1977-03-04 00:00:00

abstract：:We have previously shown that increased dosage of the mouse protein zero gene (Mpz) causes a dysmyelinating neuropathy in transgenic (Tg80) mice. To ask whether the dysmyelination is dose dependent, we inbred one of the Tg80 lines and compared the resulting phenotype in homozygous and heterozygous mice. Whereas hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Quattrini A,Feltri ML,Previtali S,Fasolini M,Messing A,Wrabetz L

更新日期：1999-10-01 00:00:00

abstract：:Carbonic anhydrase is abundantly distributed in renal tissue and functions, as in other epithelia, to catalyze the hydration-dehydration reaction of CO2. The proximal tubule is responsible for at least 80% of whole kidney bicarbonate transport and is mediated by proton secretion. Membrane-bound carbonic anhydrase appe...

journal_title：Annals of the New York Academy of Sciences

authors： DuBose TD Jr

更新日期：1984-01-01 00:00:00

abstract：:The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the relationship between stem cells, cancer, and the esophagus; the behavior of esophageal stem cells; and the role of genetics and epigenetics in approaches to translational research. ...

journal_title：Annals of the New York Academy of Sciences

authors： Croagh D,Frede J,Jones PH,Kaur P,Partensky C,Phillips WA

更新日期：2014-09-01 00:00:00

abstract：:Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regardi...

journal_title：Annals of the New York Academy of Sciences

authors： Rodriguez-Gil DJ,Treloar HB,Miller A,Two A,Iwema C,Greer CA

更新日期：2009-07-01 00:00:00

abstract：:Previous studies in postmenopausal women have reported that estrogen treatment (ET) modulates the risk for developing Alzheimer's disease (AD). It has recently been hypothesized that there may be a "critical period" around the time of menopause during which the prescription of ET may reduce the risk of developing AD i...

journal_title：Annals of the New York Academy of Sciences

authors： Craig MC,Murphy DG

更新日期：2010-09-01 00:00:00

abstract：:When conceptualized within a developmental systems theoretical framework, resilience involves mutually beneficial, reciprocally influential relations between a person and his or her context. The key features of developmental systems theory, which stress the plasticity of these relations, lead to an optimistic view of ...

journal_title：Annals of the New York Academy of Sciences

authors： Lerner RM

更新日期：2006-12-01 00:00:00

abstract：:Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a ...

journal_title：Annals of the New York Academy of Sciences

authors： Conti P,Barbacane RC,Trakatellis M,Placido FC,Cataldo I,Reale M

更新日期：1997-12-15 00:00:00

abstract：:This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are...

journal_title：Annals of the New York Academy of Sciences

authors： Appelman HD,Streutker C,Vieth M,Neumann H,Neurath MF,Upton MP,Sagaert X,Wang HH,El-Zimaity H,Abraham SC,Bellizzi AM

更新日期：2013-10-01 00:00:00

abstract：:A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the...

journal_title：Annals of the New York Academy of Sciences

authors： Vo-Dinh T,Panjehpour M,Overholt BF

更新日期：1998-02-09 00:00:00

abstract：:Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

journal_title：Annals of the New York Academy of Sciences

authors： Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

更新日期：1999-06-22 00:00:00

abstract：:A primary impairment of the kidney sodium excretion has been documented both in hypertensive patients (EH) and genetic animal models (Milan hypertensive rat [MHS]) carrying mutations of the cytoskeletal protein adducin and/or increased plasma levels of endogenous ouabain (EO). Ouabain (OU) itself induces hypertension ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari P,Ferrandi M,Torielli L,Barassi P,Tripodi G,Minotti E,Molinari I,Melloni P,Bianchi G

更新日期：2003-04-01 00:00:00

abstract：:The current research has demonstrated that MPP+ can induce lipid peroxidation in the nigrostriatal system of rat in vivo. Antioxidant agent U-78517F and .OH scavenger DMSO may protect against MPP+ toxicity through the inhibition of .OH radical-mediated oxidative injury in the substantia nigra. These findings indicate ...

journal_title：Annals of the New York Academy of Sciences

authors： Wu RM,Mohanakumar KP,Murphy DL,Chiueh CC

更新日期：1994-11-17 00:00:00

abstract：:I(2) site-selective compounds are known to interact with and inhibit monoamine oxidase (MAO), but it remains unclear as to whether this interaction occurs through an allosteric or competitive interaction. This study used the new selective, irreversible I(2) ligand BU99006, to clarify the relationship between MAO and t...

journal_title：Annals of the New York Academy of Sciences

authors： Paterson LM,Tyacke RJ,Nutt DJ,Hudson AL

更新日期：2003-12-01 00:00:00

abstract：:Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HS,Kong KA,Chung H,Park S,Kim MH

更新日期：2007-01-01 00:00:00

abstract：:The statistical techniques developed herein show strong promise as a nonparametric extension of the classical Wing-Kristofferson decomposition of variance in isochronous tapping to include tempo drift. It is now important to establish the relative role of the three sources of variance in discriminating among unselecte...

journal_title：Annals of the New York Academy of Sciences

authors： Collier GL,Ogden RT

更新日期：2001-06-01 00:00:00

abstract：:The skeletal dysplasias or osteochondrodysplasias are a clinically and genetically heterogeneous group of disorders of bone and/or cartilage. They are characterized by abnormalities in pattering, linear growth, differentiation, and maintenance of the human skeleton. While they have been considered to be generalized di...

journal_title：Annals of the New York Academy of Sciences

authors： Rimoin DL,Cohn D,Krakow D,Wilcox W,Lachman RS,Alanay Y

更新日期：2007-11-01 00:00:00

abstract：:The entorhinal cortex, subiculum, and hippocampus have been regions of great interest in both clinical and neuropathological investigations of schizophrenia. Postmortem studies have identified numerous abnormalities, although many remain controversial or unconfirmed. Among the cellular and molecular neuropathological ...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold SE

更新日期：2000-06-01 00:00:00

abstract：:Conventional and thiophosphonate-derivatized oligonucleotides were employed to specifically regulate functional gene expression in murine T-cell hybridomas. For example, induction of apoptotic cell death following activation of T-cell hybridomas was examined using antisense oligonucleotides corresponding to several pr...

journal_title：Annals of the New York Academy of Sciences

authors： Green DR,Zheng H,Shi Y

更新日期：1992-10-28 00:00:00

abstract：:Our data show that when substance abusers are subtyped simultaneously by antisocial personality disorder and the onset of depression relative to alcohol or drug abuse, groups of people with unique personality and affective profiles are identified. The profiles are represented by measures of affect-related personality ...

journal_title：Annals of the New York Academy of Sciences

authors： Epstein EE,Ginsburg BE,Hesselbrock VM,Schwarz JC

更新日期：1994-02-28 00:00:00

abstract：:Metabolic disorders present a public health challenge of staggering proportions. In diabetes, there is an urgent need to better understand disease heterogeneity, clinical trajectories, and related comorbidities. A pressing and timely question is whether we are ready for precision medicine in diabetes. Some biological ...

journal_title：Annals of the New York Academy of Sciences

authors： Merino J,Florez JC

更新日期：2018-01-01 00:00:00

abstract：:We have shown that drinking red wine reduces oxidation of LDL. This reduction in oxidation has been attributed to the polyphenolic compounds in red wine, but the mechanisms of absorption and metabolism of these compounds has been unclear. We therefore investigated the absorption and metabolism of polyphenols using rat...

journal_title：Annals of the New York Academy of Sciences

authors： Yamashita S,Sakane T,Harada M,Sugiura N,Koda H,Kiso Y,Sezaki H

更新日期：2002-05-01 00:00:00

abstract：:Differentiation of embryonic stem (ES) cells in vitro yields abundant hematopoietic progenitors, but achieving stable hematopoietic engraftment of irradiated mice has proven difficult, begging the question of whether ES cells give rise to hematopoietic stem cells in vitro, and limiting the application of ES cells as e...

journal_title：Annals of the New York Academy of Sciences

authors： Daley GQ

更新日期：2003-05-01 00:00:00

abstract：:Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

journal_title：Annals of the New York Academy of Sciences

authors： Dye MW,Hauser PC,Bavelier D

更新日期：2008-12-01 00:00:00

abstract：:Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spine...

journal_title：Annals of the New York Academy of Sciences

authors： Wallace M,Frankfurt M,Arellanos A,Inagaki T,Luine V

更新日期：2007-02-01 00:00:00

abstract：:Functional decline of tissues in aged animals is a result of cellular aging. Though any process of somatic cell aging basically depends on genomic instructions, phenotypes of aged cells are expressed in a given internal environment of each cell type that was made with translated proteins and post-translationally modif...

journal_title：Annals of the New York Academy of Sciences

authors： Toda T

更新日期：2001-04-01 00:00:00