Abstract:
:The GEANT4 application for tomographic emission (GATE) is one of the most detailed Monte Carlo simulation tools for SPECT and PET. It allows for realistic phantoms, complex decay schemes, and a large variety of detector geometries. However, only a fraction of the information in each particle history is available for postprocessing. In order to extend the analysis capabilities of GATE, a flexible framework was developed. This framework allows all detected events to be subdivided according to their type: In PET, true coincidences from others, and in SPECT, geometrically collimated photons from others. The framework of the authors can be applied to any isotope, phantom, and detector geometry available in GATE. It is designed to enhance the usability of GATE for the study of contamination and for the investigation of the properties of current and future prototype detectors. The authors apply the framework to a case study of Bexxar, first assuming labeling with 124I, then with 131I. It is shown that with 124I PET, results with an optimized window improve upon those with the standard window but achieve less than half of the ideal improvement. Nevertheless, 124I PET shows improved resolution compared to 131I SPECT with triple-energy-window scatter correction.
journal_name
Med Physjournal_title
Medical physicsauthors
De Beenhouwer J,Staelens S,Vandenberghe S,Verhaeghe J,Van Holen R,Rault E,Lemahieu Idoi
10.1118/1.3078045subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1053-60issue
4eissn
0094-2405issn
2473-4209journal_volume
36pub_type
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