Abstract:
BACKGROUND:Pathological avoidance is a transdiagnostic characteristic of anxiety disorders. Avoidance conditioning re-emerged as a translational model to examine mechanisms and treatment of avoidance. However, its validity for anxiety disorders remains unclear. METHODS:This study tested for altered avoidance in patients with anxiety disorders compared to matched controls (n = 40/group) using instrumental conditioning assessing low-cost avoidance (avoiding a single aversive outcome) and costly avoidance (avoidance conflicted with gaining rewards). Autonomic arousal and threat expectancy were assessed as indicators of conditioned fear. Associations with dimensional symptom severity were examined. RESULTS:Patients and controls showed frequent low-cost avoidance without group differences. Controls subsequently inhibited avoidance to gain rewards, which was amplified when aversive outcomes discontinued. In contrast, patients failed to reduce avoidance when aversive and positive outcomes competed (elevated costly avoidance) and showed limited reduction when aversive outcomes discontinued (persistent costly avoidance). Interestingly, elevated costly avoidance was not linked to higher conditioned fear in patients. Moreover, individual data revealed a bimodal distribution of costly avoidance: Some patients showed persistent avoidance, others showed little to no avoidance. Persistent versus low avoiders did not differ in other task-related variables, response to gains and losses in absence of threat, sociodemographic data, or clinical characteristics. CONCLUSIONS:Findings suggest that anxious psychopathology is associated with a deficit to inhibit avoidance in presence of competing positive outcomes. This offers novel perspectives for research on mechanisms and treatment of anxiety disorders.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Pittig A,Boschet JM,Glück VM,Schneider Kdoi
10.1002/da.23119subject
Has Abstractpub_date
2020-12-01 00:00:00eissn
1091-4269issn
1520-6394pub_type
杂志文章abstract:BACKGROUND:In this study, we examined executive control of attention in individuals with contamination-related obsessive-compulsive (OC) symptoms using a modified version of the Eriksen flanker task. The task indexes one's ability to resolve attentional conflict between different responses and to ignore task distracter...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20703
更新日期:2010-09-01 00:00:00
abstract::Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. METHODS:Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a re...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-01 00:00:00
abstract::The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Serotonergic (5-hydroxytryptamine; 5-HT) mechanisms have been implicated in a number of physiological and pathophysiological processes including mood, anxiety, and cognitive functioning. Among the many 5-HT receptor subtypes, the 5-HT2A receptors (5-HT2A-R) seem to be of particular importance in mediating these effect...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20087
更新日期:2005-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22088
更新日期:2013-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22082
更新日期:2013-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21991
更新日期:2013-03-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20528
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/1520-6394(2000)12:2<78::AID-DA3>3.0.CO;2-5
更新日期:2000-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22173
更新日期:2014-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22557
更新日期:2017-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22990
更新日期:2020-05-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20131
更新日期:2006-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22628
更新日期:2017-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22871
更新日期:2019-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20715
更新日期:2010-08-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20377
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析,评审
doi:10.1002/da.22634
更新日期:2017-12-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20679
更新日期:2010-03-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22527
更新日期:2017-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22688
更新日期:2018-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.21974
更新日期:2012-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20027
更新日期:2004-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20036
更新日期:2004-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00