Abstract:
:A multicentre clinical trial was carried out to determine the activity and tolerability of ofloxacin in the treatment of lower respiratory tract infections. 667 patients were randomly allocated to 1 of 3 different twice daily dosage regimens: 400 mg (245 patients), 600 mg (211) or 800 mg (211). The mean duration of treatment was 8.77 +/- 2.62 days. Satisfactory overall clinical results (i.e. cured or improved) were obtained in 612 of 667 patients (91.8%). Eradication of pathogens was achieved for 279 of 354 isolated strains (78.8%). Side effects were observed in 31 patients and consisted of gastrointestinal disturbance (22), skin rash (1), neurological disturbance (3) and others (5). No significant alteration of haematological parameters was reported.
journal_name
Drugsjournal_title
Drugsauthors
Grassi C,Gialdroni Grassi G,Mangiarotti Pdoi
10.2165/00003495-198700341-00017subject
Has Abstractpub_date
1987-01-01 00:00:00pages
80-2eissn
0012-6667issn
1179-1950journal_volume
34 Suppl 1pub_type
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