2-Deoxy-D-glucose (2-DG)-induced increase in gastric acid secretion is impaired in capsaicin-pretreated rats.

Abstract:

:This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected. These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.

journal_name

Adv Exp Med Biol

authors

Evangelista S,Santicioli P,Maggi CA

doi

10.1007/978-1-4899-0744-8_27

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

301-6

eissn

0065-2598

issn

2214-8019

journal_volume

298

pub_type

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