Abstract:
:This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected. These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Evangelista S,Santicioli P,Maggi CAdoi
10.1007/978-1-4899-0744-8_27subject
Has Abstractpub_date
1991-01-01 00:00:00pages
301-6eissn
0065-2598issn
2214-8019journal_volume
298pub_type
杂志文章abstract::Photoactivated adenylyl cyclase (PAC) was first discovered to be a sensor for photoavoidance in the flagellate Euglena gracilis. PAC is a flavoprotein that catalyzes the production of cAMP upon illumination with blue light, which enables us to optogenetically manipulate intracellular cAMP levels in various biological ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-981-15-8763-4_7
更新日期:2021-01-01 00:00:00
abstract::Advances in the design of cochlear implants (CIs), as well as improved CI surgical techniques, have led to an increase in the number of patients who retain some residual low-frequency acoustic hearing in the implanted ear. Many of these patients also possess some hearing in the unimplanted ear. Although their low-freq...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4614-1590-9_28
更新日期:2013-01-01 00:00:00
abstract::Simultaneous measurements of left and right scrotal, and axillary skin temperatures were recorded in 58 consecutive adolescents (mean age 14.4 years) with a grade II-III left sided varicocele, and nine control adolescents without genital pathology (mean age 15.7 years). Left and right testicular volumes were determine...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-5913-5_28
更新日期:1991-01-01 00:00:00
abstract::We have shown that bovine HMW kininogen remarkably accelerates the activation of Factor XII and prekallikrein in the presence of kaolin, adsorbing on kaolin through the fragment 1.2 region and forming a complex with prekallikrein through the light chain region (Sugo et al., 1980; Ikari et al., 1981). The present study...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Photoprotective mechanisms have been evolved by photosynthetic organisms to cope with fluctuating high light conditions. One of these mechanisms downregulates photosynthesis by increasing thermal dissipation of the energy absorbed by the photosystem II antenna. While this process has been well studied in plants, the e...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4419-1528-3_9
更新日期:2010-01-01 00:00:00
abstract::Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD), characterized by glomerulosclerosis and tubulointerstitial fibrosis (TIF). Recent studies h...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-13-8871-2_23
更新日期:2019-01-01 00:00:00
abstract::Pulmonary hypertension (PH) is a deadly and increasingly prevalent vascular disease characterized by excessive pulmonary vascular remodeling and right ventricular dysfunction which leads to right heart failure, multiorgan dysfunction, and premature death. The cause of the vascular remodeling in PH remains elusive, and...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-63245-2_24
更新日期:2017-01-01 00:00:00
abstract::Jørgensen and Dau (J Acoust Soc Am 130:1475-1487, 2011) proposed the speech-based envelope power spectrum model (sEPSM) in an attempt to overcome the limitations of the classical speech transmission index (STI) and speech intelligibility index (SII) in conditions with nonlinearly processed speech. Instead of consideri...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4614-1590-9_38
更新日期:2013-01-01 00:00:00
abstract::Overpopulation of selected groups of animals is widely recognised as an issue that can have adverse effects on several current global problems, such as animal and human health, conservation and environmental changes. This review will, therefore, focus on recent novel contraception together with future technologies tha...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4939-0820-2_18
更新日期:2014-01-01 00:00:00
abstract::The development of secretory IgA was followed in saliva of 263 children from birth to age 5, and in cross sectional studies of Australian school children and Papua New Guinea highland children from birth to age 5. Salivary IgA first appeared after the first week of life, peaking at 6 weeks, and falling again at 12 wee...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-3838-7_9
更新日期:1991-01-01 00:00:00
abstract::According to our present knowledge hypometabolism and hypothermia in uremia are most probably due to direct actions of toxic substances at the cellular level. A cardiovascular etiology seems less possible. A similar reduction of oxygen consumption as observed in uremia can be produced by 5 mg/kg body wt. indole i.p. A...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-8240-9_13
更新日期:1987-01-01 00:00:00
abstract::During S-phase both DNA replication and histone deposition must be co-ordinated at and around the replication fork. Replication stress can interfere with the fidelity of this process and can result in genomic instability. The study of proteins associated with DNA replication forks is important for a detailed understan...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-319-26666-4_3
更新日期:2016-01-01 00:00:00
abstract::Direct studies linking drugs of abuse with changes in neurotransmitters and subsequent effects on the immune system are not abundant. One can, however, hypothesize that an indirect effect can occur since a variety of neurotransmitters known to be acted on by various drugs of abuse can, in turn, be correlated with chan...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4684-5925-8_2
更新日期:1991-01-01 00:00:00
abstract::The revised sequence of DaaA means that the protein is 98% identical to the afimbrial adhesin regulator AFAA-III. While PapB repressed FimB OFF to ON switching in strain AAEC370A, this was not the case for DaaA. PapB, but not DaaA, reduced the level of expression of type 1 fimbriae, in static LB media. Attention is no...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/0-306-46840-9_20
更新日期:2000-01-01 00:00:00
abstract::The carbapenems have the broadest spectra of all beta-lactams but resistance still occurs, caused by target modification, impermeability or beta-lactamase production. Target modification or replacement is important in methicillin-resistant staphylococci, E. faecium and some pneumococci. These organisms present the gre...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4757-9203-4_3
更新日期:1995-01-01 00:00:00
abstract::The audibility of a target tone is improved by introducing either -amplitude modulations that are coherent across different frequency channels of the masker (comodulation masking release, CMR) or interaural phase differences that are -different for target and masker (binaural masking-level difference, BMLD). Although ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4614-1590-9_48
更新日期:2013-01-01 00:00:00
abstract::Possible non-transmitter roles for 5-HT in different phases of early neuroembryogenesis have been discussed based upon experimental evidence from the rat and chick. Fluorescence histochemical studies have demonstrated sites of uptake and synthesis of 5-HT in the chick embryo during the first few days of incubation. Th...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4684-3860-4_28
更新日期:1981-01-01 00:00:00
abstract::Alzheimer's disease, a type of dementia, affects memory, behavior, and cognitive processes in affected individuals. It is one of the prominent diseases, accounting for 60-80% of dementia cases and affecting a significant population of persons over the age of 65 years. While rare, Alzheimer's disease (AD) may affect th...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-96445-4_14
更新日期:2018-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptors (PPARs) are multi-domains proteins, belonging to the superfamily of nuclear receptors, which mainly act as ligand-activated transcription factors. A variety of lipophilic molecules, including long-chain polyunsaturated fatty acids and eicosanoids, are capable of binding to P...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-030-11488-6_3
更新日期:2019-01-01 00:00:00
abstract::Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylheptanoic acid (statine). The complete structu...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4757-0719-9_12
更新日期:1977-01-01 00:00:00
abstract::Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease. L...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-030-50621-6_7
更新日期:2020-01-01 00:00:00
abstract::[Hydroxyproline3]Lysyl-bradykinin ([Hyp3]Lys-BK), a new kinin was isolated, besides Lysyl-bradykinin (Lys-BK), from the reaction mixture of human plasma protein Cohn's fraction IV-4 with hog pancreatic kallikrein. The liberated kinins were isolated by procedures including ethanol extraction, Sephadex G-15, CM cellulos...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-9543-4_83
更新日期:1989-01-01 00:00:00
abstract::Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Volume 1 international leading experts will present up-to-date overviews about t...
journal_title:Advances in experimental medicine and biology
pub_type:
doi:10.1007/978-94-007-0763-4_1
更新日期:2011-01-01 00:00:00
abstract::It has long been known that endogenous pyrogen, released as a result of injection of typhoid vaccine or in response to infection, produces fever and increases ACTH secretion. Recent studies have indicated that endogenous pyrogen is, at least in part, IL-1. This monokine has now been shown to activate the release of AC...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4684-5799-5_20
更新日期:1990-01-01 00:00:00
abstract::Biodegradable materials based on polymers of hydroxy acids are studied for application in artificial vascular substitutes. Polymers with functional surfaces are being developed, carrying specific recognition structures to affect selectively the adhesion and proliferation of endothelial cells (EC) and vascular smooth m...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::We identified a 45 kDa Ca(2+)-dependent Lf binding protein on rat hepatocytes. Dithiobis(sulfosuccimidylproprionate) (DTSSP)-crosslinked 125I-Lf to a 45 kDa adduct in a Ca(2+)-dependent manner on intact cells. The 125I-labeled crosslinked complexes were absent when either surface-bound 125I-Lf was stripped prior to cr...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Alterations in structural and biochemical properties of muscles that underlie physiological parameters of contractile force, speed and fatigability are described under conditions of 1) overuse: imposed electrical stimulation, natural exercise and functional overload; 2) reinnervation of denervated muscles; and 3) unde...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::This chapter discusses the emerging field of vector-mediated antibody gene transfer as an alternative vaccine for infectious disease, with a specific focus on HIV. However, this methodology need not be confined to HIV-1; the general strategy of vector-mediated antibody gene transfer can be applied to other difficult v...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4939-2432-5_8
更新日期:2015-01-01 00:00:00
abstract::Cutaneous receptors in the foot sole appear to contribute to the control of human stance and locomotion. Two approaches were undertaken to establish the characteristics of the receptors in the sole. Psychophysical vibrotactile thresholds (range 25-400 Hz) were determined across the unloaded sole in young and elderly s...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-0713-0_14
更新日期:2002-01-01 00:00:00
abstract::The ability to differentiate between well-oxygenated and poorly-oxygenated tumors may play an important role in selecting an optimal therapeutic regime for tumor treatment of the individual patient. We present preliminary results in the development of a dynamic functional MRI method for mapping tissue oxygenation and ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-0075-9_42
更新日期:2003-01-01 00:00:00