Dose-response association between adult height and all-cause mortality: a systematic review and meta-analysis of cohort studies.

Abstract:

BACKGROUND:We conducted a systematic review and meta-analysis from published cohort studies to examine the association of adult height and all-cause mortality and to further explore the dose-response association. METHODS:PubMed, The Cochrane Library, The Ovid, CNKI, CQVIP and Wanfang databases were searched for articles published from database inception to 6 February 2018. We used the DerSimonian-Laird random-effects model to estimate the quantitative association between adult height and all-cause mortality and the restricted cubic splines to model the dose-response association. RESULTS:We included 15 articles, with 1 533 438 death events and 2 854 543 study participants. For each 5-cm height increase below the average, the risk of all-cause mortality was reduced by 7% [relative risk (RR) = 0.93, 95% confidence interval (CI), 0.89-0.97] for men and 5% (RR = 0.95, 95% CI, 0.90-0.99) for women. All-cause mortality had a U-shaped association with adult height, the lowest risk occurring at 174 cm for men and 158 cm for women (both Pnonlinearity < 0.001). Relative to the shortest adult height (147 cm for men and 137 cm for women), men at 174 cm had a 47% lower likelihood of all-cause mortality and women at 158 cm a 33% lower risk of all-cause mortality. CONCLUSIONS:Our study suggests that the relation between adult height and all-cause mortality is approximately U-shaped in both men and women.

journal_name

Eur J Public Health

authors

Li Q,Liu Y,Sun X,Li H,Cheng C,Liu L,Liu F,Zhou Q,Guo C,Tian G,Qie R,Han M,Huang S,Li L,Wang B,Zhao Y,Ren Y,Zhang M,Hu D,Wu J,Lu J

doi

10.1093/eurpub/ckaa213

subject

Has Abstract

pub_date

2020-11-25 00:00:00

eissn

1101-1262

issn

1464-360X

pii

6000720

pub_type

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