Betahistine hydrochloride (Serc) in cerebrovascular disease: a placebo-controlled study.

abstract：AIMS/OBJECTIVES:to study associations between the likelihood of hospital death with patient demographics, cause of death and co-morbidities for people aged ≥85 at death who have been previously admitted (within 12 months of death) to hospital. METHODS:a cross-sectional study, using death registration data and hospital...

journal_title：Age and ageing

authors： Pocock LV,Ives A,Pring A,Verne J,Purdy S

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention. METHODS:We undertook a pragmatic, multi-national, parallel arm prospective random...

journal_title：Age and ageing

authors： O'Mahony D,Gudmundsson A,Soiza RL,Petrovic M,Jose Cruz-Jentoft A,Cherubini A,Fordham R,Byrne S,Dahly D,Gallagher P,Lavan A,Curtin D,Dalton K,Cullinan S,Flanagan E,Shiely F,Samuelsson O,Sverrisdottir A,Subbarayan S,V

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:to evaluate the effectiveness of a multifactorial intervention on incidence of falls in psychogeriatric nursing home patients. DESIGN:cluster-randomised controlled 12-month trial. SETTING:psychogeriatric wards in 12 nursing homes in The Netherlands. PARTICIPANTS:psychogeriatric nursing home patients (n = 5...

journal_title：Age and ageing

authors： Neyens JC,Dijcks BP,Twisk J,Schols JM,van Haastregt JC,van den Heuvel WJ,de Witte LP

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:animal studies suggest a neuroprotective role for leptin, but human studies have shown mixed results. We examined whether plasma leptin levels in individuals with mild cognitive impairment (MCI) were related to cognitive function at baseline and whether higher leptin levels were associated with reduced risk ...

journal_title：Age and ageing

authors： Oania R,McEvoy LK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:the nursing home Resident Assessment Instrument (RAI) includes a set of core assessment items, known as the Minimum Data Set (MDS), for assessment and care screening and more detailed Resident Assessment Protocols in 18 areas that represent common problem areas or risk factors for nursing home residents. Its...

journal_title：Age and ageing

authors： Hawes C,Morris JN,Phillips CD,Fries BE,Murphy K,Mor V

更新日期：1997-09-01 00:00:00

abstract：:The capacity of peripheral blood mononuclear cells (PBMC) isolated from patients with Alzheimer's disease to produce interleukin-1 and -2 (IL-1, IL-2) was compared to that of cells from age-matched controls and young healthy subjects. There was no difference in the production of both interleukins between patients and ...

journal_title：Age and ageing

authors： Bessler H,Sirota P,Hart J,Djaldetti M

更新日期：1989-01-01 00:00:00

abstract：:Spasticity is common after stroke and other neurological conditions and causes considerable limitations of movement, activities of daily living and participation. Interaction with other components of the upper motor neurone syndrome (UMNS) and the heterogeneity of patients' presentations together with limited tools fo...

journal_title：Age and ageing

authors： Graham LA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:geriatrics encompasses diverse medical, social and ethical challenges requiring a multidimensional, interdisciplinary approach. Recent reports have highlighted failings in the care of older people. It is therefore vital that trainees in geriatrics are afforded opportunities to develop skills in managing this...

journal_title：Age and ageing

authors： Braude P,Reedy G,Dasgupta D,Dimmock V,Jaye P,Birns J

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Delirium is a common neuropsychiatric disorder. The natural course is of an acute, fluctuating and often transient condition; however, accumulating evidence suggests that delirium can be associated with incomplete recovery. Despite a growing body of research, a lack of clarity exists regarding definition and...

journal_title：Age and ageing

authors： Adamis D,Devaney A,Shanahan E,McCarthy G,Meagher D

更新日期：2015-03-01 00:00:00

abstract：PRESENTATION:an 83-year-old man was admitted to hospital with acute confusion 3 days after a direct flight from Australia. OUTCOME:computed tomography (CT) brain scan and magnetic resonance imaging head scan revealed the cause to be pneumocephalus, apparently the result of barotrauma caused by Valsalva manoeuvres when...

journal_title：Age and ageing

authors： Chan YP,Yau CY,Lewis RR,Kinirons MT

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:self-rated health (SRH) likely reflects both mental and physical health domains, and is assessed by asking individuals to describe their health status. Poor SRH is associated with disease incidence and subsequent mortality. Changes in SRH across time in persons with different incident diseases are uncharacte...

journal_title：Age and ageing

authors： Foraker RE,Rose KM,Chang PP,McNeill AM,Suchindran CM,Selvin E,Rosamond WD

更新日期：2011-11-01 00:00:00

abstract：:From December 1982 to August 1983, a total of 242 oesophago-gastro-duodenoscopies were performed for 208 elderly patients in the Geriatric Unit, Princess Margaret Hospital, Hong Kong. These were done as part of an investigatory procedure in the Geriatric Unit, the first of its kind in Hong Kong. In the 9-month survey,...

journal_title：Age and ageing

authors： Lee YC,Tam HC

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:fifteen percent of patients with Crohn's disease (CD) are elderly; they are less likely to have complications and more likely to have colonic disease. OBJECTIVE:to compare disease behaviour in patients with CD based on age at diagnosis. DESIGN:cross-sectional study. SETTING:tertiary referral centre. SUBJ...

journal_title：Age and ageing

authors： Quezada SM,Steinberger EK,Cross RK

更新日期：2013-01-01 00:00:00

abstract：:The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no a...

journal_title：Age and ageing

authors： Elmståhl S,Petersson M,Lilja B,Samuelsson SM,Rosén I,Bjunö L

更新日期：1992-07-01 00:00:00

abstract：:From a study of routine electrocardiography on 300 ill elderly patients in an acute geriatric unit, it is evident that the incidence of atrial fibrillation, ventricular extrasystoles, myocardial ischaemia and myocardial infarction is much higher than in the general population of similar age group. In females, the inci...

journal_title：Age and ageing

authors： Patel KP

更新日期：1977-08-01 00:00:00

abstract：:Doppler-shifted ultrasound and spectral analysis were used to assess signals from the resting supra-orbital artery and the common carotid artery at the base of the neck of 658 (270 male, 388 female) asymptomatic subjects aged 5 to 90 years. The sonagrams obtained showed two peaks (A and B) during cardiac systole. The ...

journal_title：Age and ageing

authors： Baskett JJ,Lewis RR,Beasley MG,Gosling RG

更新日期：1985-03-01 00:00:00

abstract：:We present two cases of acute hepatotoxicity associated with elevated paracetamol (acetaminophen) levels in older patients. Both patients were receiving a standard European dose of oral paracetamol (2 × 500 mg QDS) with no risk factors for slowed metabolism (weight <50 kg, interacting medications, hepatic enzyme induc...

journal_title：Age and ageing

authors： Ging P,Mikulich O,O'Reilly KM

更新日期：2016-07-01 00:00:00

abstract：:We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remai...

journal_title：Age and ageing

authors： George G,Wynne H,Woodhouse K

更新日期：1991-11-01 00:00:00

abstract：:Congestive heart failure (CHF) is the most common discharge diagnosis for elderly patients. The survival of elderly (age greater than or equal to 75 years) patients with CHF has not recently been reported, especially with reference to left ventricular ejection fraction (LVEF). A patient database was searched for the d...

journal_title：Age and ageing

authors： Taffet GE,Teasdale TA,Bleyer AJ,Kutka NJ,Luchi RJ

更新日期：1992-01-01 00:00:00

abstract：:Lower urinary tract symptoms are frequency report in Parkinson's disease. Whether these are causally related to Parkinson's disease rather than the known effects of age on the urinary tract is unknown. In this study we compared urodynamic data from 1864 women and 357 men with no neurological disease with data from 34 ...

journal_title：Age and ageing

authors： Gray R,Stern G,Malone-Lee J

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...

journal_title：Age and ageing

authors： Jenkin RP,Al-Attar A,Richardson S,Myint PK,MacLullich AM,Davis DH

更新日期：2016-07-01 00:00:00

abstract：Background:harmful alcohol consumption is reported to be increasing in older people. To intervene and reduce associated risks, evidence currently available needs to be identified. Methods:two systematic reviews in older populations (55+ years): (1) Interventions to prevent or reduce excessive alcohol consumption; (2) ...

journal_title：Age and ageing

authors： Kelly S,Olanrewaju O,Cowan A,Brayne C,Lafortune L

更新日期：2018-03-01 00:00:00

abstract：:Clinical assessments have to be used in epidemiological studies in the absence of more objective means of establishing diagnosis or recording events in the natural history of disease. This requires the standardization of definition, technique and interpretation as a means of reducing observer variability in clinical e...

journal_title：Age and ageing

authors： Garraway WM,Akhtar AJ,Gore SM,Prescott RJ,Smith RG

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:the terminal decline hypothesis suggests an acceleration in the rate of loss of cognitive function before death. Evidence about the association of educational attainment and the onset of terminal decline is scarce. OBJECTIVE:to investigate the association of education with the onset of terminal decline in g...

journal_title：Age and ageing

authors： Terrera GM,Minett T,Brayne C,Matthews FE

更新日期：2014-01-01 00:00:00

abstract：:Among 352 residents of a home for the elderly, who were fully mobile and devoid of most predisposing factors for bacteriuria, 19% of men and 27% of women had two positive cultures within two months. Positive conversion at one year among men and women negative at entry was 11% and 23% respectively, negative conversion ...

journal_title：Age and ageing

authors： Kasviki-Charvati P,Drolette-Kefakis B,Papanayiotou PC,Dontas AS

更新日期：1982-08-01 00:00:00

abstract：:Recent studies have shown a defect in the cholinergic system of the cerebral cortex of patients suffering from nonvascular senile dementia. This observation suggests the possibility of instituting some kind of replacement therapy and trial have been carried out. At this juncture it seem pertinent to ask what lessons c...

journal_title：Age and ageing

authors： Kendall MJ

更新日期：1979-05-01 00:00:00

abstract：:Sporadic Creutzfeld-Jakob disease (CJD) is a rare neurodegenerative disorder. It is uniformly fatal. Clinical signs include myoclonus, visual disturbances, cerebellar ataxia, akinetic mutism and pyramidal/extrapyramidal signs in addition to a rapidly progressive dementia. Premortem diagnosis is challenging due to the ...

journal_title：Age and ageing

authors： Podger H,Ipe A

更新日期：2020-04-27 00:00:00

abstract：BACKGROUND:in a secondary analysis of a randomised controlled trial, we investigated whether 6 months of music-based multitask training had beneficial effects on cognitive functioning and mood in older adults. METHODS:134 community-dwellers aged ≥65 years at increased risk for falling were randomly assigned to either ...

journal_title：Age and ageing

authors： Hars M,Herrmann FR,Gold G,Rizzoli R,Trombetti A

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:to investigate the effectiveness of a pharmacy discharge plan in elderly hospitalized patients. DESIGN:randomized controlled trial. SUBJECTS AND SETTINGS:we randomized patients aged 75 years and older on four or more medicines who had been discharged from three acute general and one long-stay hospital to a...

journal_title：Age and ageing

authors： Nazareth I,Burton A,Shulman S,Smith P,Haines A,Timberal H

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:to examine whether the Danish 1905 cohort members had more active hospital treatment than the 1895 cohort members from ages 85 to 99 years and whether it results in higher in-hospital and post-operative mortality. METHODS:in the present register-based follow-up study the complete Danish birth cohorts born in...

journal_title：Age and ageing

authors： Oksuzyan A,Jeune B,Juel K,Vaupel JW,Christensen K

更新日期：2013-07-01 00:00:00