Abstract:
BACKGROUND:Prevalence and contribution of intracranial and extracranial arterial stenosis to stroke risk were assessed prospectively in children and young adults with sickle cell disease. METHODS:In this cross-sectional study, children and young adults (mean = 19.4 years) with sickle cell disease underwent neurological examination, brain MRI, and magnetic resonance angiography of the head and neck. Two neuroradiologists independently recorded infarcts and arterial stenosis. Clinical features and stroke outcomes were compared between participants with and without stenosis and between children and young adults. Logistic regression analysis assessed the association of variables of interest with overt stroke and silent cerebral infarct. RESULTS:Of 167 participants (79 children and 88 young adults), 20 (12.0%) had intracranial stenosis, all in the anterior circulation, and nine had concurrent extracranial stenosis. No participants had isolated extracranial stenosis. Participants with intracranial stenosis were more likely than those without stenosis to have an overt stroke (70% vs 5%, P < 0.001) or silent cerebral infarct (95% vs 35%, P < 0.001). Logistic regression analysis indicated that intracranial stenosis was strongly associated with overt stroke when compared with participants with silent cerebral infarct alone and strongly associated with silent cerebral infarct when compared with participants with normal brain MRI; male sex and age were also significant predictors of silent cerebral infarct. CONCLUSIONS:Intracranial stenosis was strongly associated with both overt stroke and silent cerebral infarct; prevalence of intracranial stenosis was similar to prior estimates in sickle cell disease. Extracranial stenosis without concurrent intracranial stenosis did not occur and thus could not be evaluated as an independent risk factor for stroke.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Schlotman AA,Donahue MJ,Kassim AA,Lee CA,Waddle SL,Pruthi S,Davis LT,Rodeghier M,DeBaun MR,Jordan LCdoi
10.1016/j.pediatrneurol.2020.10.006subject
Has Abstractpub_date
2021-01-01 00:00:00pages
29-34eissn
0887-8994issn
1873-5150pii
S0887-8994(20)30340-4journal_volume
114pub_type
杂志文章abstract::Seizures are an early sign of brain injury in newborns. These seizures are in most cases repetitive or associated with asymptomatic electrographic seizures. Despite the relative resistance of the immature brain to seizure-induced brain damage, there is more and more evidence that neonatal seizures impair normal brain ...
journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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doi:10.1016/s0887-8994(98)00114-3
更新日期:1999-02-01 00:00:00
abstract::Once-daily ethosuximide was used to treat 10 consecutive children with typical absence seizures. Three patients had gastrointestinal side effects which resolved when the same total daily dose was divided into 2 doses. Two other patients continued to have seizures on ethosuximide, whether given once or twice daily. Fiv...
journal_title:Pediatric neurology
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doi:10.1016/0887-8994(90)90076-d
更新日期:1990-01-01 00:00:00
abstract::The expression of tumor necrosis factor alpha (TNF alpha) was examined in infants with leukomalacia by means of immunohistochemical methods with an antihuman TNF alpha monoclonal antibody. We studied 23 patients with neonatal leukomalacia, classified as having "focal," "widespread," or "diffuse" disease according to t...
journal_title:Pediatric neurology
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doi:10.1016/0887-8994(95)00223-5
更新日期:1996-01-01 00:00:00
abstract::Two half-siblings with schizencephaly are presented. They have the same mother who had a normal cerebral imaging study. Only one other kindred was found in which 2 siblings had this cerebral lesion. In the present patients, autosomal inheritance from the mother is possible, but other explanations should include famili...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(92)90039-2
更新日期:1992-03-01 00:00:00
abstract::Magnetic resonance imaging (MRI) changes reported after corpus callosotomy include hyperintensity in the corpus callosum, perifalcine hyperintensity caused by surgical retraction, and acute changes associated with surgical complications. The authors have observed MRI signal changes in the cerebral white matter of corp...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(99)00082-x
更新日期:1999-10-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2012.12.032
更新日期:2013-05-01 00:00:00
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journal_title:Pediatric neurology
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更新日期:2015-01-01 00:00:00
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journal_title:Pediatric neurology
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doi:10.1016/s0887-8994(03)00011-0
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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doi:10.1016/s0887-8994(02)00491-5
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Nuclear polymerase gamma (POLG) mutations are the most common cause of inherited mitochondrial disease. POLG mutation diseases have a broad spectrum of clinical manifestations; the lethal infantile form is myocerebrohepatopathy spectrum. PATIENT:A 4-month-old boy was referred for poor feeding, emesis, failu...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2014.06.015
更新日期:2014-11-01 00:00:00
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journal_title:Pediatric neurology
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更新日期:2016-07-01 00:00:00
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journal_title:Pediatric neurology
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doi:10.1016/j.pediatrneurol.2012.06.012
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journal_title:Pediatric neurology
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doi:10.1016/j.pediatrneurol.2007.12.004
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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更新日期:2014-12-01 00:00:00
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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更新日期:1985-03-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 临床试验,杂志文章
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更新日期:2009-05-01 00:00:00