Abstract:
:As the field of tissue engineering evolves, there will be an increasingly important need to visualize and track the complex dynamic changes that occur within three-dimensional constructs. Optical coherence tomography (OCT), as an emerging imaging technology applied to biological materials, offers a number of significant advantages to visualize these changes. Structural OCT has been used to investigate the longitudinal development of engineered tissues and cell dynamics such as migration, proliferation, detachment, and cell-material interactions. Optical techniques that image functional parameters or integrate multiple imaging modalities to provide complementary contrast mechanisms have been developed, such as the integration of optical coherence microscopy with multiphoton microscopy to image structural and functional information from cells in engineered tissue, optical coherence elastography to generate images or maps of strain to reflect the spatially-dependent biomechanical properties, and spectroscopic OCT to differentiate different cell types. From these results, OCT demonstrates great promise for imaging and visualizing engineered tissues, and the complex cellular dynamics that directly affect their practical and clinical use.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Liang X,Graf BW,Boppart SAdoi
10.1002/jbio.200910048subject
Has Abstractpub_date
2009-11-01 00:00:00pages
643-55issue
11eissn
1864-063Xissn
1864-0648journal_volume
2pub_type
杂志文章,评审abstract::Clinicians need a way to rapidly and reliably test the correct functioning of near-infrared spectroscopy (NIRS)-based oximeters. Therefore, optical phantoms for quality assessment of NIRS oximeters are needed. The fabrication of such phantoms that mimic the optical properties of biological tissue in the NIR range repr...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800300
更新日期:2019-04-01 00:00:00
abstract::The authors have developed a tomographic diffractive microscope that combines microholography with illumination from an angular synthetic aperture. It images specimens relative to their complex index of refraction distribution (index and absorption) and permits imaging of unlabelled specimens, with high lateral resolu...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.200900094
更新日期:2010-07-01 00:00:00
abstract::Perfusion and oxygenation are critical parameters of muscle metabolism in health and disease. They have been both the target of many studies, in particular using near-infrared spectroscopy (NIRS). However, difficulties with quantifying NIRS signals have limited a wide dissemination of the method to the clinics. Our ai...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201960169
更新日期:2020-06-01 00:00:00
abstract::Biophotonics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to solve the problems appearing in biology and medicine. In China, the Biophotonics discipline is often referred to as Biomedical Photonics, under the first-level disciplines Biomedical Engin...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201790012
更新日期:2017-12-01 00:00:00
abstract::Diffuse reflectance spectroscopy is a rapidly growing technology in the biophotonics community where it has shown promise in its ability to classify different tissues. In the steady-state domain a wide spectrum of clinical applications is supported with this technology ranging from diagnostic to guided interventions. ...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201300198
更新日期:2015-01-01 00:00:00
abstract::We investigate the optical wavelength dependence in quantitative photoacoustic (QPA) assessment of red blood cell (RBC) aggregation and oxygen saturation (sO2 ) during pulsatile blood flow. Experimentally, the pulsatile flow was imaged with a 700 to 900 nm laser using the VevoLAZR. Theoretically, the photoacoustic (PA...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700300
更新日期:2018-08-01 00:00:00
abstract::The purpose of this study was to evaluate thermal and near-infrared (NIR) reflectance imaging methods for the assessment of the activity of root caries lesions. In addition, changes in the lesion structure were monitored with polarization sensitive optical coherence tomography (PS-OCT). Artificial bovine and natural r...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500333
更新日期:2017-03-01 00:00:00
abstract::We report a compact, cost-effective tuned amplifier for frequency-selective amplification of the modulated signal in heterodyne detected nonlinear optical microscopy. Our method improved the signal to noise ratio by an order of magnitude compared to conventional lock-in detection, as demonstrated through stimulated Ra...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201200005
更新日期:2012-10-01 00:00:00
abstract::Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the a...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500236
更新日期:2016-05-01 00:00:00
abstract::A plastic optical fibre biosensor based on surface plasmon resonance for the detection of C-reactive protein (CRP) in serum is proposed. The biosensor was integrated into a home-made thermo-stabilized microfluidic system that allows avoiding any thermal and/or mechanical fluctuation and maintaining the best stable con...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500315
更新日期:2016-10-01 00:00:00
abstract::In vivo microscopy has recently become a gold standard in lung immunology studies involving small animals, largely benefiting from the democratization of multiphoton microscopy allowing for deep tissue imaging. This technology represents currently our only way of exploring the lungs and inferring what happens in human...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201500246
更新日期:2016-09-01 00:00:00
abstract::In fluctuation-based optical nanoscopy, investigating high-density labeled subcellular structures with high fidelity has been a significant challenge. In this study, based on super-resolution radial fluctuation (SRRF) microscopy, the joint tagging (JT) strategy is employed to enable fast high-density nanoscopic imagin...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800020
更新日期:2018-09-01 00:00:00
abstract::The processes associated with pollen germination were studied in vitro for two tree species, Salix caprea and Fraxinus excelsior under different nutrient conditions. The results provide evidence of changes in chemical composition of the pollen grains during germination. From the comparison of spectra of the pollen gra...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000031
更新日期:2010-08-01 00:00:00
abstract::Pancreatic islet isolation from donor pancreases is an essential step for the transplantation of insulin-secreting β-cells as a therapy to treat type 1 diabetes mellitus. This process however damages islet basement membranes, which can lead to islet dysfunction or death. Posttransplantation, islets are further stresse...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000375
更新日期:2020-12-01 00:00:00
abstract::Photodynamic therapy (PDT) uses photosensitizers and visible light in combination with molecular oxygen to produce reactive oxygen species (ROS) that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature and stimulate the host immune system. The excited singlet state of oxygen (1 O2 )...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201600055
更新日期:2016-12-01 00:00:00
abstract::The research work presented in this paper focuses on qualitative tissue differentiation by monitoring the intensity ratios of atomic emissions using 'Laser Induced Breakdown Spectroscopy' (LIBS) on the plasma plume created during laser tissue ablation. The background of this study is to establish a real time feedback ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300159
更新日期:2015-01-01 00:00:00
abstract::A new optical scattering contrast-agent based on polymer-nanoparticle encapsulated silver nanoplates (PESNs) is presented. Silver nanoplates were chosen due to the flexibility of tuning their plasmon frequencies. The polymer coating preserves their physical and optical properties and confers other advantages such as c...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500177
更新日期:2016-07-01 00:00:00
abstract::Spahr et al. recently commented on our latest paper "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" with a conclusion that the measured retinal pulse wave velocity (rPWV) in our paper was contradictory to theoretical predictions and previously published results. However, th...
journal_title:Journal of biophotonics
pub_type: 评论,杂志文章
doi:10.1002/jbio.201700379
更新日期:2018-02-01 00:00:00
abstract::Atherosclerosis is a process of thickening and stiffening of the arterial walls through the accumulation of lipids and fibrotic material, as a consequence of aging and unhealthy life style. However, not all arterial plaques lead to complications, which can lead to life-threatening events such as stroke and myocardial ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800013
更新日期:2018-12-01 00:00:00
abstract::A novel hybrid method which combines sub-wavelength-scale phase measurements and pixel-scale displacement tracking for robust strain mapping in compressional optical coherence elastography is proposed. Unlike majority of OCE methods it does not rely on initial reconstruction of displacements and does not suffer from t...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500203
更新日期:2016-05-01 00:00:00
abstract::Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air-puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000104
更新日期:2020-08-01 00:00:00
abstract::Photobiomodulation (PBM) therapy has been noted to promote cell proliferation and growth in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are used in the clinic for a variety of ailments, including wound healing. However, most protocols treat an anatomical site without consid...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600025
更新日期:2016-12-01 00:00:00
abstract::Mucosal lesions of the upper aerodigestive tract usually concern the squamous epithelium of the surface. Many precancerous alterations now designated as potentially malignant are caused by DNA damage resulting from long term exposure to tobacco and alcohol consumption. The distinction from conditions with a similar ph...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201100085
更新日期:2012-04-01 00:00:00
abstract::Despite an ever increasing demand for reliable and cheap methods in the detection and quantification of microbes, surprisingly few investigations have explored or utilized the luminescence of rare earths in the microbial context, neither in conventional, that is, plating and microscopic imaging techniques, nor in adva...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000068
更新日期:2020-09-01 00:00:00
abstract::Microfluidics and photonics come together to form a field commonly referred to as 'optofluidics'. Flow cytometry provides the field with a technology base from which both microfluidic and photonic components be developed and integrated into a useful device. This article reviews some of the more recent developments to ...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.200810018
更新日期:2008-10-01 00:00:00
abstract::Several studies have demonstrated the potential of cross-polarization optical coherence tomography (CP-OCT) to quantify the severity of early caries lesions (tooth decay) on tooth surfaces. The purpose of this study is to show that 2D images of the lesion depth and the integrated reflectivity can be used to accurately...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300137
更新日期:2015-01-01 00:00:00
abstract::Compared to conventional techniques, Laser surgery procedures provide a number of advantages, but may be associated with an increased risk of iatrogenic damage to important anatomical structures. The type of tissue ablated in the focus spot is unknown. Laser-Induced Breakdown-Spectroscopy (LIBS) has the potential to g...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600153
更新日期:2017-10-01 00:00:00
abstract::The content of dermal beta-carotene can be a good indicator showing the body health. Because, it is involved in production of vitamin A maintaining healthy skin and mucous membranes. Also, it reduces the risk of cardiovascular diseases and its antioxidant capacity prevents the formation of cancerous cells. In this wor...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000124
更新日期:2020-09-01 00:00:00
abstract::Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the hi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300043
更新日期:2014-10-01 00:00:00
abstract::Basidiomycetes, that is, mushroom-type fungi, are known to produce pigments in response to environmental impacts. As antioxidants with a high level of unsaturation, these compounds can neutralize highly oxidative species. In the event of close contact with other microbes, the enzymatically controlled pigment productio...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700369
更新日期:2018-06-01 00:00:00