Abstract:
:Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Phan C,Beneton N,Delaunay J,Reguiai Z,Boulard C,Fougerousse AC,Cinotti E,Romanelli M,Mery-Bossard L,Thomas-Beaulieu D,Parier J,Maccari F,Perrot JL,Ruer-Mulard M,Bastien M,Begon E,Samimi M,Jacobzone C,Quiles-Tsimaratosdoi
10.2340/00015555-3678subject
Has Abstractpub_date
2020-11-04 00:00:00pages
adv00316issue
18eissn
0001-5555issn
1651-2057journal_volume
100pub_type
杂志文章abstract::Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing preforms of matrix-metalloproteinases, growth factors and adhesion molecul...
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abstract::Itch is known to be associated with psychological factors in adults, but has not been explored among adolescents. A cross-sectional, questionnaire-based population study involving adolescents born mostly in 1986 was carried out in 2004. A total of 4744 individuals were invited and the participation rate was 80%. The H...
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