Effectiveness and Safety of Anti-interleukin-17 Therapies in Elderly Patients with Psoriasis.

Abstract:

:Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.

journal_name

Acta Derm Venereol

authors

Phan C,Beneton N,Delaunay J,Reguiai Z,Boulard C,Fougerousse AC,Cinotti E,Romanelli M,Mery-Bossard L,Thomas-Beaulieu D,Parier J,Maccari F,Perrot JL,Ruer-Mulard M,Bastien M,Begon E,Samimi M,Jacobzone C,Quiles-Tsimaratos

doi

10.2340/00015555-3678

subject

Has Abstract

pub_date

2020-11-04 00:00:00

pages

adv00316

issue

18

eissn

0001-5555

issn

1651-2057

journal_volume

100

pub_type

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