Abstract：
:Social anxiety disorder (SAD) has been linked to maladaptive forms of fear regulation, including flexibly distinguishing between learned threat and safety signals. Few studies have examined this in young, unmedicated SAD patients, including its neural basis. We aimed to characterize the neural, subjective, and autonomic correlates of reversal learning in patients with SAD and compare them to matched patients with major depressive disorder and to healthy control participants. All participants completed a threat-safety reversal learning task during functional magnetic resonance imaging. Successful threat-safety updating was associated with significant activation of primary regions of interest (anterior cingulate, insula and ventromedial prefrontal cortex), however, no significant differences were observed between them, consistent with subjective reports of task-evoked anxiety and affect. Contrary to expectations, we did not observe threat and safety reversal learning to be significantly impaired in young people with SAD.
journal_name
J Anxiety Disordjournal_title
Journal of anxiety disordersauthors
Savage HS,Davey CG,Fullana MA,Harrison BJdoi
10.1016/j.janxdis.2020.102321subject
Has Abstractpub_date
2020-12-01 00:00:00pages
102321eissn
0887-6185issn
1873-7897pii
S0887-6185(20)30135-3journal_volume
76pub_type
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pub_type： 杂志文章
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