Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients.

Abstract:

:Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (≤ 18 years of age) with cutaneous leishmaniasis treated with miltefosine in Israel was performed. Mean ± standard deviation age at diagnosis was 9.1 ± 5.0 years. The Leishmania species diagnosed was L. tropica in 8 cases and Leishmania major in 2 cases. Mean ± standard deviation duration of treatment was 44.8 ± 20.6 days, with a mean follow-up period of 12.1 ± 17.1 months. Complete response was noted in 8 (80%) patients. Treatment failure was noted in 2 (20%) cases. Side-effects related to the medication were minimal. In conclusion, oral miltefosine may be an effective and safe treatment for Old World cutaneous leishmaniasis caused by Leishmania tropica or Leishmania major in children. However, further studies are warranted to draw a definite conclusion.

journal_name

Acta Derm Venereol

authors

Ollech A,Solomon M,Horev A,Reiss-Huss S,Ben-Amitai D,Zvulunov A,Friedland R,Atar-Snir V,Molho-Pessach V,Barzilai A,Greenberger S

doi

10.2340/00015555-3669

subject

Has Abstract

pub_date

2020-10-19 00:00:00

pages

adv00322

issue

18

eissn

0001-5555

issn

1651-2057

journal_volume

100

pub_type

杂志文章
  • Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice.

    abstract::Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Ito S,Wakamatsu K,Inoue S,Fujita K

    更新日期:1989-01-01 00:00:00

  • Dose-response relationship between objective measures of histamine-induced weals and dose of terfenadine.

    abstract::Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared with pre-treatment measurements, in order to compare the dose-effect relat...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Shall L,Newcombe RG,Lush M,Marks R

    更新日期:1991-01-01 00:00:00

  • Systemic contact dermatitis from herbal and homeopathic preparations used for herpes virus treatment.

    abstract::Systemic contact dermatitis may occur in contact-sensitized individuals when they are exposed to haptens orally, transcutaneously, intravenously or by inhalation. We report the case of a woman developing a diffuse skin eruption after the topical use of Rhus toxicodendron alcoholic extract and the oral introduction of ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550410023293

    authors: Cardinali C,Francalanci S,Giomi B,Caproni M,Sertoli A,Fabbri P

    更新日期:2004-01-01 00:00:00

  • The role of vascular surgery in chronic leg ulcers: report from a specialized ulcer clinic.

    abstract::Experience gained from cooperation between dermatologists and vascular surgeons in 177 patients evaluated at a joint leg ulcer clinic is reported. Patients were divided into two subgroups: (i) 86 patients with healed ulcers and (ii) 91 patients with ongoing therapy-resistant ulcers. Venous insufficiency was the most c...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155502320323225

    authors: Bjellerup M,Akesson H

    更新日期:2002-01-01 00:00:00

  • Mycosis fungoides plaque stage treated with topical nitrogen mustard with and without attempts at tolerance induction: report from the Scandinavian mycosis fungoides study group.

    abstract::The Scandinavian Mycosis Fungoides Study Group has treated 21 patients with mycosis fungoides in plaque stages with topical, whole-body application of nitrogen mustard, 20 mg in 40 ml water per square metre. Ten patients were treated after previous attempts at intravenous tolerance induction ad modum van Scott & Kalma...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Molin L,Thomsen K,Volden G

    更新日期:1979-01-01 00:00:00

  • Shift in Occupational Risk for Basal Cell Carcinoma from Outdoor to Indoor Workers: A Large Population-based Case-control Register Study from Sweden.

    abstract::Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-2660

    authors: Lindelöf B,Lapins J,Dal H

    更新日期:2017-07-06 00:00:00

  • Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis.

    abstract::The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, C...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,随机对照试验

    doi:10.2340/00015555-2579

    authors: Kubin ME,Kokkonen N,Palatsi R,Hägg PM,Väyrynen JP,Glumoff V,Haapasaari KM,Hurskainen T,Tasanen K

    更新日期:2017-04-06 00:00:00

  • Pemphigus Vulgaris Persistently Localized to the Nose with Local and Systemic Response to Topical Steroids.

    abstract::is missing (Short communication). ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-2725

    authors: Zhang C,Goldscheider I,Ruzicka T,Sárdy M

    更新日期:2017-10-02 00:00:00

  • Expression of blood group antigens by cultured human epidermal cells used as allografts.

    abstract::The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Mauduit G,Ohrt C,Faure M,Kanitakis J,Demidem A,Thivolet J

    更新日期:1987-01-01 00:00:00

  • Expression of transglutaminase I in human anagen hair follicles.

    abstract::The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555575190192

    authors: Tamada Y,Takama H,Kitamura T,Ikeya T,Yokochi T

    更新日期:1995-05-01 00:00:00

  • Serum reactivity against herpes simplex virus type 1 UL48 protein in Behçet's disease patients and a Behçet's disease-like mouse model.

    abstract::Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-2127

    authors: Zheng Z,Sohn S,Ahn KJ,Bang D,Cho SB

    更新日期:2015-11-01 00:00:00

  • Frequency and distribution pattern of melanocytic naevi in Swedish 8-9-year-old children.

    abstract::The naevus profile was examined in a Swedish cohort of 8-9-year-old children; 524/545 individuals (96%) were examined (279 boys and 245 girls). There was a wide variation in the total number of naevi (0-79) and boys had more naevi than girls (median 9 and 7, respectively, p<0.01). No dysplastic naevi were found. Overa...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550410025903

    authors: Synnerstad I,Nilsson L,Fredrikson M,Rosdahl I

    更新日期:2004-01-01 00:00:00

  • Comparative multi-center study with TRUE Test and Finn Chamber Patch Test methods in eight Swedish hospitals.

    abstract::292 individuals were patch tested with twelve allergens, using a new patch test technique, TRUE Test (TT). As controls, the same allergens in standard concentrations in petrolatum were applied using the Finn Chamber technique (FC). The allergen doses used in TT were chosen according to results from a previous serial d...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ruhnek-Forsbeck M,Fischer T,Meding B,Pettersson L,Stenberg B,Strand A,Sundberg K,Svensson L,Wahlberg JE,Widström L

    更新日期:1988-01-01 00:00:00

  • A Case of Pork-cat Syndrome That Developed as Food-dependent Exercise-induced Anaphylaxis.

    abstract::is missing (Short communication). ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3584

    authors: Shiratsuki R,Chinuki Y,Fukushiro S,Morita E

    更新日期:2020-08-17 00:00:00

  • Circulating immune complexes in a patient with prolonged gonococcal septicemia.

    abstract::A case of prolonged gonococcal speticemia is presented. Lack of genital symptoms, of demonstrable gonococcal antibodies in whole serum, and initially also of skin lesions contributed to a delayed diagnosis that was finally confirmed by positive blood culture. Evidence of circulating immune complexes was obtained by th...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Danielsson D,Norberg R,Svanbom M

    更新日期:1975-01-01 00:00:00

  • Cutaneous blood flow rates during orthostatic manoeuvres measured by laser Doppler flowmetry.

    abstract::The validity of Laser Doppler Flowmetry for measurements of changes in skin blood flow rates during orthostatic manoeuvres was evaluated. Fifteen healthy subjects were investigated. Relative skin blood flow rates on the dorsum of the hand were measured during stepwise raising and lowering of the arm in 10 cm increment...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555570144147

    authors: Petersen LJ,Sindrup JH

    更新日期:1990-01-01 00:00:00

  • Increased Risk of Pemphigus among Patients with Psoriasis: A Large-scale Cohort Study.

    abstract::Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort st...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3607

    authors: Kridin K,Ludwig RJ,Damiani G,Cohen AD

    更新日期:2020-10-20 00:00:00

  • Cutaneous Manifestations of Granulomatosis with Polyangiitis: A Case Series Study.

    abstract::The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all g...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3506

    authors: Montero-Vilchez T,Martinez-Lopez A,Salvador-Rodriguez L,Del Carmen Ramírez-Barberena M,Tercedor-Sanchez J,Molina-Leyva A,Arias-Santiago S

    更新日期:2020-05-28 00:00:00

  • Expression of loricrin in skin disorders.

    abstract::Loricrin, the major component of the cornified envelope, is normally expressed in the granular layer of epidermis during the last steps of keratinocyte differentiation. Using an antiloricrin antiserum (A8-73), an increased expression of this envelope precursor was found in some disorders of hyperorthokeratosis (ichthy...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555572407409

    authors: Juhlin L,Magnoldo T,Darmon M

    更新日期:1992-11-01 00:00:00

  • Premalignant nature of oral lichen planus.

    abstract::The issue as to whether oral lichen planus is a premalignant disorder is still controversial. This study aimed to examine oral malignancies associated with oral lichen planus and to investigate whether oral lichen planus has an intrinsic malignant potential or whether there are also contributing external risk factors....

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550510036676

    authors: Laeijendecker R,van Joost T,Kuizinga MC,Tank B,Neumann HA

    更新日期:2005-01-01 00:00:00

  • Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis.

    abstract::The aim of this study is to assess the associations between chronic spontaneous urticaria (CSU), Helicobacter pylori infection and small intestinal bacterial overgrowth. Forty- eight patients with CSU were studied by scoring the urticaria activity and assesing the quality of life. Patients with H. pylori infection (n=...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1373

    authors: Campanati A,Gesuita R,Giannoni M,Piraccini F,Sandroni L,Martina E,Conocchiari L,Bendia E,Di Sario A,Offidani A

    更新日期:2013-03-27 00:00:00

  • Sensitization capacity of polyester methacrylate in ultraviolet curing inks tested in the guinea pig.

    abstract::One of the prepolymers used in Ultraviolet (UV) curing ink formulations is acrylated polyester. The prepolymer investigated is a dimethacrylated polyester, thus a saturated polyester terminated with methacrylic groups. In conventional UV-curing coatings the prepolymer commonly used is an unsaturated polyester. Three o...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Björkner B

    更新日期:1982-01-01 00:00:00

  • The cutaneous signs of eating disorders.

    abstract::Anorexia nervosa and bulimia nervosa are common yet occult eating disorders which each affect between 1 and 2% of young adult women in the UK (1). Cutaneous signs may provide valuable clues allowing earlier diagnosis. Eating disorders may both imitate (Table I) and complicate other medical illnesses, resulting in unne...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555746869

    authors: Siddiqui A,Ramsay B,Leonard J

    更新日期:1994-01-01 00:00:00

  • Initiation of the effects of acrivastine and cetirizine on histamine-induced wheals and itch in human skin.

    abstract::The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross-over design employing 20 healthy medical students. The prick test was performed before ingestion...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2340/0001555573350351

    authors: Lahti A,Haapaniemi T

    更新日期:1993-10-01 00:00:00

  • Dermatology life quality index: data from Danish inpatients and outpatients.

    abstract::The aim of the present study was to provide data on the reliability and validity of a Danish translation of the Dermatology Life Quality Index (DLQI), a short measure of the impact of dermatological diseases on quality of life. The DLQI was administered to 200 outpatients and 100 hospitalized patients suffering from a...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155500750012153

    authors: Zachariae R,Zachariae C,Ibsen H,Mortensen JT,Wulf HC

    更新日期:2000-07-01 00:00:00

  • Lichenoid drug eruption with palmoplantar hyperkeratosis due to imatinib mesylate: a case report and a review of the literature.

    abstract::Cutaneous adverse effects of imatinib mesylate (Glivec) are common and various types of skin eruptions have been reported. We report here a 57-year-old man who presented with lichen planus-like lesions on his extremities and palmoplantar hyperkeratosis due to the use of imatinib mesylate for chronic myeloid leukaemia....

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,评审

    doi:10.2340/00015555-0758

    authors: Kuraishi N,Nagai Y,Hasegawa M,Ishikawa O

    更新日期:2010-01-01 00:00:00

  • Affinity of 3H-8-MOP to human chromosomes and cells.

    abstract::Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Wulf HC,Niebuhr E

    更新日期:1980-01-01 00:00:00

  • Early changes in human epidermis following thermal burn: an electron microscopic study.

    abstract::Early alterations in the epidermis of human volunteers following 60 degrees and 95 degrees C burns were studied by means of electron microscopy. The blister was induced at 30 seconds following a 60 degrees C burn for 1 and 3 minutes by disintegration of the basal cells just above the basement membrane, and, in additio...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Takigawa M,Ofuji S

    更新日期:1977-01-01 00:00:00

  • Nodules on the legs. A clinical, histological and immunohistological study of 82 patients representing different types of nodular panniculitis.

    abstract::Eighty-two cases of nodular panniculitis of the legs were examined clinically, histologically and immunohistologically. Clinically the cases could be divided into four groups: typical erythema nodosum (ENty) (35 cases), erythema nodosum migrans (ENmi) (11 cases), erythema induratum (EI) (11 cases) and the remaining 25...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Niemi KM,Förström L,Hannuksela M,Mustakallio KK,Salo OP

    更新日期:1977-01-01 00:00:00

  • Non-specific immunity in patients with primary anogenital warts treated with interferon alpha plus cryotherapy or cryotherapy alone.

    abstract::Combination treatment of primary anogenital warts with subcutaneous interferon alpha 2a plus cryotherapy was no more efficacious than cryotherapy alone. Patients with primary AG warts showed no in vitro or in vivo suppression of non-specific immunity. In patients treated with interferon plus cryotherapy non-specific c...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:102340/00015555723940

    authors: Handley JM,Maw RD,Horner T,Lawther H,McNeill T,Dinsmore WW

    更新日期:1992-01-01 00:00:00