A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.

abstract：:Important implications for the recognition of iron deficiency anaemia include diagnosis and correction of underlying causes, most of which are identifiable, in the older patient, by means of conventional upper gastrointestinal endoscopy, and by colonoscopy. The aetiological search may, however, have to be widened to i...

journal_title：Postgraduate medical journal

authors： Jolobe OM

更新日期：2000-04-01 00:00:00

abstract：:Both the quality and the quantity of food ingested are relevant to the genesis of risk factors for coronary heart disease and the two are inseparable. Nevertheless they have a major common pathway through hypertension, which may well be the most important consequence of a high-protein, high-carbohydrate, high-fat, hig...

journal_title：Postgraduate medical journal

authors： Brook CG

更新日期：1978-03-01 00:00:00

abstract：:Altogether 42 million people worldwide have been infected with HIV, and 12 million have died over the last 20 years. Effective antiretroviral therapy has lead to sustained HIV viral suppression and immunological recovery in patients who have been infected with the virus. The incidence of AIDS has declined in the Weste...

journal_title：Postgraduate medical journal

authors： Thaker HK,Snow MH

更新日期：2003-01-01 00:00:00

abstract：:This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain. Although methadone is most widely known for its use in the treatment of opioid dependence, methadone also provides effective analgesia. Pa...

journal_title：Postgraduate medical journal

authors： Brown R,Kraus C,Fleming M,Reddy S

更新日期：2004-11-01 00:00:00

abstract：:Three patients are described in whom one or more carotid territory transient ischaemic attacks (TIAs) were preceded by sneezing, straining, or bending over. It is argued that the mechanism involved dislodgment of embolic material from the site of carotid atheroma. This mechanism should be considered as an alternative ...

journal_title：Postgraduate medical journal

authors： Harrison MJ

更新日期：1999-03-01 00:00:00

abstract：:This paper reviews the development of cerebral scintigraphy from its early days of planar imaging with simple technetium-99m labelled compounds to the recent revival of the technique in the form of positron-emission and single-photon emission tomography. A short explanation of instrumentation and radiopharmaceuticals ...

journal_title：Postgraduate medical journal

authors： Shepstone BJ

更新日期：1988-01-01 00:00:00

abstract：:The first case of the Zollinger-Ellison syndrome treated from the outset continuously for more than a year with the histamine H2-receptor antagonist cimetidine is reported. Symptomatic response has been dramatic and sustained, marked endoscopic improvement has been observed with healing of oesophageal, gastric and sto...

journal_title：Postgraduate medical journal

authors： Larkworthy W,Davies HL

更新日期：1977-12-01 00:00:00

abstract：:Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical d...

journal_title：Postgraduate medical journal

authors： Shenkin A

更新日期：2006-09-01 00:00:00

abstract：:Lymphocyte adenosine deaminase (L-ADA) activity, a measure of lymphocyte activity, was estimated in 10 healthy controls and 30 patients with typhoid fever (20 uncomplicated and 10 complicated) at the time of admission, at onset of complications and weekly until recovery. Mean L-ADA activity in healthy controls was 20....

journal_title：Postgraduate medical journal

authors： Khosla SN,Kumar D,Singh V

更新日期：1992-04-01 00:00:00

abstract：:Most consultants are involved in the training and assessment of several grades of doctors in training especially senior house officers (SHOs) and specialist registrars. In the medical and other specialties there is an increasing trend towards assessing junior doctors' competency using the record of in-training assessm...

journal_title：Postgraduate medical journal

authors： Carr SJ

更新日期：2004-02-01 00:00:00

abstract：:Participant modelling, a behaviourally-orientated treatment technique, is an effect method of treating phobias associated with minor medical procedures or apparatus such as needles or intravenous catheters. The steps in this technique are described and two cases of severe needle phobias successfully treated with parti...

journal_title：Postgraduate medical journal

authors： Taylor CB,Ferguson JM,Wermuth BM

更新日期：1977-01-01 00:00:00

abstract：PURPOSE OF THE STUDY:There are approximately 35 000 in-hospital cardiac arrests in the UK each year. Successful resuscitation requires integration of the medical science, training and education of clinicians and implementation of best practice in the clinical setting. In 2015, the International Liaison Committee on Res...

journal_title：Postgraduate medical journal

authors： Carberry J,Couper K,Yeung J

更新日期：2017-11-01 00:00:00

abstract：:This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis. ...

journal_title：Postgraduate medical journal

authors： D'Costa DF,Vania AK,Millac PA

更新日期：1990-10-01 00:00:00

abstract：:The pharmacokinetics of a single oral dose of clomipramine were examined in a group of depressed patients, 8 female and 2 male with a mean age of 51 years (range 21-78). Their mean clomipramine half-life was 36 hours and mean plasma clomipramine clearance 73 litres per hour, with a wide range in each case. These resul...

journal_title：Postgraduate medical journal

authors： Dawling S,Braithwaite RA,McAuley R,Montgomery SA

更新日期：1980-01-01 00:00:00

abstract：:The Wolff-Parkinson-White syndrome can rarely present with pre-excited atrial fibrillation. In this condition the short refractory period of the accessory pathway can lead to rapid atrioventricular conduction. There is then a danger that at high heart rates the irregular broad complex tachycardia that results can dete...

journal_title：Postgraduate medical journal

authors： Adlam D,Azeem T

更新日期：2003-05-01 00:00:00

abstract：:The characteristics of three combinations of thiopentone and etomidate [in the ratios of thiopentone (mg):etomidate (mg) of 5:1, 13:1 and 25:1] have been compared with the individual agents alone for the induction of anaesthesia. The incidence of pain on injection and abnormal movements was less with the combination c...

journal_title：Postgraduate medical journal

authors： Slater RM,Pollard BJ,Young TM,Hunt LP

更新日期：1990-07-01 00:00:00

abstract：:A patient with an aggressive intrasinusoidal non-Hodgkins lymphoma, presenting with marked systemic disturbance but only a mildly raised alkaline phosphatase as a localising sign is described. All imaging studies of the liver were normal and the diagnosis was delayed until a percutaneous liver biopsy was performed. On...

journal_title：Postgraduate medical journal

authors： Camidge R,Ong E,Lucraft H

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Transient ischaemic attacks (TIAs) carry a significant early risk of stroke. New national guidelines state patients should be seen within 7 days of the incident, with higher-risk patients being seen within 24 h. Meeting these targets across the NHS poses a significant challenge. A novel approach to TIA asses...

journal_title：Postgraduate medical journal

authors： Banerjee S,Natarajan I,Biram R,Sutton K,Ekeng G,Ames D,Chataway J

更新日期：2009-12-01 00:00:00

abstract：:The diagnosis and early management of genitourinary disorders in children is challenging for the child, parents and carers. There have been enormous developments in paediatric care medically and surgically and as a result many patients with complex anomalies reach adult life and have a normal desire for a good quality...

journal_title：Postgraduate medical journal

authors： Creighton SM,Wood D

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Post-radiation large vessel injury has not received as much attention as microvascular irradiation injury. A few studies have shown that common carotid intima-media thickness (IMT) is increased after radiotherapy to the head and neck. However, in most of these studies, the irradiated subjects also had other ...

journal_title：Postgraduate medical journal

authors： Shariat M,Alias NA,Biswal BM

更新日期：2008-11-01 00:00:00

abstract：:In 114 patients (52 males and 62 females) with long-standing pernicious anaemia, hypoferritinaemia was found in 27 (23.7%) and hypochromic microcytic anaemia in 19 (16.6%). Our findings indicate that iron deficiency is a common yet neglected complication of long-standing pernicious anaemia and warrants greater diagnos...

journal_title：Postgraduate medical journal

authors： Atrah HI,Davidson RJ

更新日期：1988-02-01 00:00:00

abstract：:Duodenal carcinoids are rare tumours. There is an increased incidence of primary carcinomas, especially in the gastrointestinal tract, which occur synchronously with gastrointestinal tract carcinoids. However, the synchronous occurrence of adenocarcinoma of the gastro-oesophageal junction with a duodenal carcinoid has...

journal_title：Postgraduate medical journal

authors： McCabe HL

更新日期：2001-04-01 00:00:00

abstract：:Rhabdomyolysis is a rare but potentially fatal complication of hyperosmolar states. We report a case of severe hyperosmolar non-ketotic diabetic coma causing rhabdomyolysis in a young man. Despite very high levels of creatine kinase there was no detectable myoglobinuria. Creatine kinase estimation should be a standard...

journal_title：Postgraduate medical journal

authors： Trump D,O'Hanlon S,Rinsler M,Sharp P

更新日期：1994-01-01 00:00:00

abstract：:The clinical significance of the abnormalities seen at left ventriculography in ischaemic heart disease is discussed. Aneurysms may be recognized when left ventriculography is combined with coronary arteriography to show the characteristic obliteration of the supplying artery. Localized areas of abnormal contraction s...

journal_title：Postgraduate medical journal

authors： Khattri HN,Raphael MJ,Sharma B,Steiner RE,Goodwin JF

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:For gastroenterology, The Royal College of Physicians reiterates the common practice of two to three consultant ward rounds per week. The Royal Bolton Hospital NHS Foundation Trust operated a 26-bed gastroenterology ward, covered by two consultants at any one time. A traditional system of two ward rounds per...

journal_title：Postgraduate medical journal

authors： Singh S,Lipscomb G,Padmakumar K,Ramamoorthy R,Ryan S,Bates V,Crompton S,Dermody E,Moriarty K

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To analyse the clinicopathological presentation, outcome and importance of bone marrow haemophagocytosis in patients with infection-associated haemophagocytic lymphohistiocytosis (IA-HLH) in a tertiary care hospital in Northern India. STUDY DESIGN:Between January 2007 and December 2009, 26 consecutive patien...

journal_title：Postgraduate medical journal

authors： Nair V,Das S,Sharma A,Sharma S,Sharma P,Ray S,Bhattacharya S

更新日期：2013-04-01 00:00:00

abstract：:A patient is described with severe haemorrhage from a lumbar artery following percutaneous renal biopsy. The exact source of haemorrhage in this previously unreported complication proved difficult to locate even at surgical exploration. ...

journal_title：Postgraduate medical journal

authors： Jamison MH,Coward RA

更新日期：1985-01-01 00:00:00

abstract：:Submucosal dissection of the oesophagus is a rare oesophageal disorder. We report a patient who had recurrent episodes of dissection and achalasia. Both recurrence and the association with achalasia are to our knowledge unique. ...

journal_title：Postgraduate medical journal

authors： Hooper TL,Gholkar J,Smith SR,Manns JJ,Moussalli H

更新日期：1986-10-01 00:00:00

abstract：:During one year, out of 1829 faecal specimens examined at the Chelmsford Public Health Laboratory, campylobacters were isolated from 109 (6%), 21 of the positive cultures were from hospital in-patients and 3 were from hospital staff. The remaining 85 isolates were from specimens sent in by general practitioners. The a...

journal_title：Postgraduate medical journal

authors： Bradshaw MJ,Brown R,Swallow JH,Rycroft JA

更新日期：1980-02-01 00:00:00

abstract：:Mild and self-limiting fever following bleomycin use is common, and a fatal hyperpyrexial response occurs rarely. In previously reported cases, such hyperpyrexia occurred either after the initial administration of the drug or during subsequent therapy following an initial pyrexial response. We describe a fatal hyperpy...

journal_title：Postgraduate medical journal

authors： Leung WH,Lau JY,Chan TK,Kumana CR

更新日期：1989-06-01 00:00:00