Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system.

Abstract:

PURPOSE:To explore the ability of whole-body 7.0-T magnetic resonance (MR) imaging to depict differences in aspects of the cerebral cortex of postmortem human brain specimens with cerebral amyloid beta deposition in connection with Alzheimer disease (AD), Down syndrome, or sporadic or hereditary cerebral amyloid angiopathy (CAA) and control brain specimens lacking such deposition. MATERIALS AND METHODS:This study was approved by the local institutional review board. In all cases, informed consent was obtained to perform autopsy and to use the tissues for research purposes. T2- and T2*-weighted MR imaging was performed in formalin-fixed samples of brain tissue from six subjects with AD changes, seven with CAA, and five subjects without immunohistochemical evidence of cerebral amyloid beta deposition. All MR images were visually assessed for hypointense foci in and inhomogeneity of the cortex. Sensitivity, specificity, and kappa values of these MR imaging features in the detection of histologic changes were calculated. RESULTS:High-spatial-resolution 0.3 x 0.3 x 0.3-mm three-dimensional T2*-weighted images revealed hypointense foci, inhomogeneity of the cortex, or both in all specimens with brain amyloid beta deposition. These MR imaging features were observed in none of the control specimens. CONCLUSION:The finding of postmortem susceptibility-weighted changes in the cerebral cortex of patients with cerebral amyloidosis with a human 7.0-T MR imaging system opens up the possibility of obtaining in vivo radiologic evidence of cerebral amyloid beta deposition.

journal_name

Radiology

journal_title

Radiology

authors

van Rooden S,Maat-Schieman ML,Nabuurs RJ,van der Weerd L,van Duijn S,van Duinen SG,Natté R,van Buchem MA,van der Grond J

doi

10.1148/radiol.2533090490

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

788-96

issue

3

eissn

0033-8419

issn

1527-1315

pii

radiol.2533090490

journal_volume

253

pub_type

杂志文章
  • US-based Real-time Elastography for the Detection of Fibrotic Gut Tissue in Patients with Stricturing Crohn Disease.

    abstract:PURPOSE:To assess whether ultrasonography (US)-based real-time elastography (RTE) can be used to detect gut fibrosis. MATERIALS AND METHODS:In this institutional review board-approved, prospective, proof-of-concept study, unaffected and affected gut segments in 10 patients with Crohn disease (four women, six men; medi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14141929

    authors: Baumgart DC,Müller HP,Grittner U,Metzke D,Fischer A,Guckelberger O,Pascher A,Sack I,Vieth M,Rudolph B

    更新日期:2015-06-01 00:00:00

  • Gender Differences in Academic Rank of Radiologists in U.S. Medical Schools.

    abstract::Purpose To determine whether there were gender differences in full professorship after accounting for factors known to influence academic advancement. Materials and Methods Institutional review board approval was obtained for this HIPAA-compliant study, with waiver of informed consent. In this cross-sectional study, t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016160950

    authors: Kapoor N,Blumenthal DM,Smith SE,Ip IK,Khorasani R

    更新日期:2017-04-01 00:00:00

  • Mangement of squamous cell carcinoma of the oral tongue and floor of mouth after excisional biopsy.

    abstract::A review of the records of 23 patients with squamous cell carcinoma of the oral tongue and floor of mouth treated with irradiation after excisional biopsy has shown that: (a) Radiotherapy, primarily using interstitial radium implants, results in excellent local control of the primary area (100%) with preservation of f...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/116.1.143

    authors: Ange DW,Lindberg RD,Guillamondegui OM

    更新日期:1975-07-01 00:00:00

  • Computer-aided detection in screening mammography: variability in cues.

    abstract:PURPOSE:To evaluate the variability of true-positive and false-positive cues by using a commercially available computer-aided detection (CAD) system for analysis of 50 malignancies in a screening population. MATERIALS AND METHODS:Fifty breast cancers detected at screening were analyzed by using a commercially availabl...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2332031200

    authors: Baker JA,Lo JY,Delong DM,Floyd CE

    更新日期:2004-11-01 00:00:00

  • Mammography with computer-aided detection: reproducibility assessment initial experience.

    abstract:PURPOSE:To examine the performance and reproducibility of a commercially available computer-aided detection (CAD) system with a set of mammograms obtained in 100 patients who had undergone biopsy after positive findings at mammography. MATERIALS AND METHODS:One hundred positive mammographic examinations (four views ea...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2281020489

    authors: Zheng B,Hardesty LA,Poller WR,Sumkin JH,Golla S

    更新日期:2003-07-01 00:00:00

  • Radiation-induced uterine changes: MR imaging.

    abstract::To assess the capability of magnetic resonance (MR) imaging to demonstrate postirradiation changes in the uterus, MR studies of 23 patients who had undergone radiation therapy were retrospectively examined and compared with those of 30 patients who had not undergone radiation therapy. MR findings were correlated with ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.1.2909120

    authors: Arrivé L,Chang YC,Hricak H,Brescia RJ,Auffermann W,Quivey JM

    更新日期:1989-01-01 00:00:00

  • A Simplified Whole-Organ CT Perfusion Technique with Biphasic Acquisition: Preliminary Investigation of Accuracy and Protocol Feasibility in Kidneys.

    abstract:PURPOSE:To determine the feasibility and accuracy of a protocol for calculating whole-organ renal perfusion (renal blood flow [RBF]) and regional perfusion on the basis of biphasic computed tomography (CT), with concurrent dynamic contrast material-enhanced (DCE) CT perfusion serving as the reference standard. MATERIA...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015142757

    authors: Yuan X,Zhang J,Quan C,Tian Y,Li H,Ao G

    更新日期:2016-04-01 00:00:00

  • Pancreas allograft rejection: correlation of transduodenal core biopsy with Doppler resistive index.

    abstract:PURPOSE:To determine the usefulness of sonographically obtained resistive indexes (RIs) in the diagnosis of pancreas allograft rejection. MATERIALS AND METHODS:Findings were studied from 78 transduodenal pancreas allograft biopsies that were ultrasound-guided and cystoscopically directed. The 78 biopsies included 40 t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.200.1.8657950

    authors: Nelson NL,Largen PS,Stratta RJ,Taylor RJ,Grune MT,Hapke MR,Radio SJ

    更新日期:1996-07-01 00:00:00

  • Interactive real-time multiplanar CT imaging.

    abstract::A new software program provides the real-time display of high-resolution computed tomographic reformation in the axial, coronal, sagittal, or oblique views. The advantages of this new technique over the standard multiplanar format include (a) larger image display format, (b) reconstruction of entire dataset for each o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.1.2909110

    authors: Ney DR,Fishman EK,Magid D,Kuhlman JE

    更新日期:1989-01-01 00:00:00

  • Non-Hodgkin lymphoma in the porta hepatis after orthotopic liver transplantation: sonographic findings.

    abstract::The sonographic appearances of primary non-Hodgkin lymphoma developing in the porta hepatis in three patients soon after hepatic transplantation were reviewed. The lymphomas appeared as large hypoechoic masses encasing vital portal structures--the hepatic artery and the common bile duct--in all three cases and displac...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.182.3.1535910

    authors: Moody AR,Wilson SR,Greig PD

    更新日期:1992-03-01 00:00:00

  • Radionuclide studies of chronic schistosomal uropathy.

    abstract::Fifty patients with chronic urinary tract schistosomiasis were studied with 99mTc-DTPA. All had a flow study, sequential analog imaging, and digital imaging for 25-35 minutes (20-sec. frames). Time-activity curves (DTPA renograms) were extracted; 12 patients had 131I-Hippuran probe renograms as well. Renal changes inc...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.140.2.7019960

    authors: Lamki LM,Lamki N

    更新日期:1981-08-01 00:00:00

  • Focal Epilepsy: MR Imaging of Nonhemodynamic Field Effects by Using a Phase-cycled Stimulus-induced Rotary Saturation Approach with Spin-Lock Preparation.

    abstract::Purpose To investigate whether nonhemodynamic resonant saturation effects can be detected in patients with focal epilepsy by using a phase-cycled stimulus-induced rotary saturation (PC-SIRS) approach with spin-lock (SL) preparation and whether they colocalize with the seizure onset zone and surface interictal epilepti...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016150368

    authors: Kiefer C,Abela E,Schindler K,Wiest R

    更新日期:2016-07-01 00:00:00

  • Deep vein thrombosis of lower extremity: direct intraclot injection of alteplase once daily with systemic anticoagulation--results of pilot study.

    abstract:PURPOSE:To prospectively evaluate the outcome of patients with acute deep vein thrombosis (DVT) of the lower extremity treated with "lacing" of the thrombus with alteplase (recombinant tissue plasminogen activator, or rTPA). MATERIALS AND METHODS:This HIPAA-compliant study was approved by the Institutional Review Boar...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章

    doi:10.1148/radiol.2461062076

    authors: Chang R,Chen CC,Kam A,Mao E,Shawker TH,Horne MK 3rd

    更新日期:2008-02-01 00:00:00

  • Isolated choroid plexus cysts in the second-trimester fetus: is amniocentesis really indicated?

    abstract::Choroid plexus (CP) cysts have been associated with trisomy 18, although most fetuses with CP cysts are normal. Since many fetuses with trisomy 18 have other sonographic abnormalities, the necessity of obtaining a karyotype for all fetuses with isolated CP cysts remains controversial. The authors prospectively studied...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.185.2.1410370

    authors: Nadel AS,Bromley BS,Frigoletto FD Jr,Estroff JA,Benacerraf BR

    更新日期:1992-11-01 00:00:00

  • Cocaine abuse: neurovascular complications.

    abstract::In a review of the records of 3,712 drug abusers, 13 patients were identified with neurologic deficits attributable to the use of cocaine. Ischemic manifestations were the most frequent, occurring in seven (54%) patients, with a mean age of 34.2 years. Three (23%) patients had subarachnoid hemorrhage, and three (23%) ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.1.2909100

    authors: Jacobs IG,Roszler MH,Kelly JK,Klein MA,Kling GA

    更新日期:1989-01-01 00:00:00

  • Congenital heart disease in children: coronary MR angiography during systole and diastole with dual cardiac phase whole-heart imaging.

    abstract:PURPOSE:To assess the optimal timing for coronary magnetic resonance (MR) angiography in children with congenital heart disease by using dual cardiac phase whole-heart MR imaging. MATERIALS AND METHODS:The local institutional review board approved this study, and informed consent was obtained from parents or guardians...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11101659

    authors: Uribe S,Hussain T,Valverde I,Tejos C,Irarrazaval P,Fava M,Beerbaum P,Botnar RM,Razavi R,Schaeffter T,Greil GF

    更新日期:2011-07-01 00:00:00

  • Cystic fibrosis: detecting changes in airway inflammation with FDG PET/CT.

    abstract:PURPOSE:To determine if fluorine 18 fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) imaging can depict a treatment effect from intravenous antibiotics for pulmonary exacerbation in cystic fibrosis (CF). MATERIALS AND METHODS:The study was approved by the institutional review boar...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.12111873

    authors: Amin R,Charron M,Grinblat L,Shammas A,Grasemann H,Graniel K,Ciet P,Tiddens H,Ratjen F

    更新日期:2012-09-01 00:00:00

  • Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases.

    abstract:PURPOSE:To describe observations of adenohypophysitis on magnetic resonance (MR) images. MATERIALS AND METHODS:Clinical, enhanced MR imaging, surgical, and histologic findings were retrospectively studied in four female patients and one male patient with adenohypophysitis who presented with headaches, pituitary insuff...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.195.1.7892490

    authors: Ahmadi J,Meyers GS,Segall HD,Sharma OP,Hinton DR

    更新日期:1995-04-01 00:00:00

  • Three-dimensional, navigator-echo MR coronary angiography in detecting stenoses of the major epicardial vessels, with conventional coronary angiography as the standard of reference.

    abstract:PURPOSE:To test three-dimensional (3D), navigator-echo magnetic resonance (MR) coronary angiography in detecting stenoses of the coronary arteries. MATERIALS AND METHODS:Forty-two patients (age range, 50-79 years) underwent MR coronary angiography (1.5 T). A navigator-echo sequence was used. Two or three 15% overlappe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.214.3.r00mr01808

    authors: Sardanelli F,Molinari G,Zandrino F,Balbi M

    更新日期:2000-03-01 00:00:00

  • Corticospinal tract localization: integration of diffusion-tensor tractography at 3-T MR imaging with intraoperative white matter stimulation mapping--preliminary results.

    abstract::Institutional review board approval and written informed consent were obtained. The purpose of this study was to prospectively validate usefulness of diffusion-tensor (DT) fiber tractography of the corticospinal tract at 3-T magnetic resonance imaging, in combination with the subcortical motor-evoked potential (MEP) t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2403050916

    authors: Okada T,Mikuni N,Miki Y,Kikuta K,Urayama S,Hanakawa T,Fushimi Y,Yamamoto A,Kanagaki M,Fukuyama H,Hashimoto N,Togashi K

    更新日期:2006-09-01 00:00:00

  • Achilles tendons: clinical relevance of neovascularization diagnosed with power Doppler US.

    abstract:PURPOSE:To evaluate the clinical relevance of neovascularization diagnosed with power Doppler ultrasonography (US) in Achilles tendons in patients with chronic achillodynia. MATERIALS AND METHODS:Forty consecutive patients (mean age, 52 years; age range, 30-72 years) were examined. US was performed bilaterally and rep...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2272012069

    authors: Zanetti M,Metzdorf A,Kundert HP,Zollinger H,Vienne P,Seifert B,Hodler J

    更新日期:2003-05-01 00:00:00

  • Bowel obstruction following liver transplantation: clinical and ct findings in 48 cases with emphasis on internal hernia.

    abstract:PURPOSE:To review the incidence, cause, and radiologic findings of bowel obstruction in patients who have undergone orthotopic liver transplantation (OLT). MATERIALS AND METHODS:Retrospective review of 4,001 cases of OLT revealed 48 cases of bowel obstruction in 44 patients. Seventeen computed tomographic (CT) scans a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.218.2.r01ja22384

    authors: Blachar A,Federle MP

    更新日期:2001-02-01 00:00:00

  • Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography.

    abstract:PURPOSE:To determine diagnostic accuracy of four-channel multi-detector row computed tomography (CT) in emergency room and inpatient populations suspected of having acute pulmonary embolism (PE) who prospectively underwent both CT and pulmonary arteriography (PA). MATERIALS AND METHODS:Patients referred for PA to asse...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2333031744

    authors: Winer-Muram HT,Rydberg J,Johnson MS,Tarver RD,Williams MD,Shah H,Namyslowski J,Conces D,Jennings SG,Ying J,Trerotola SO,Kopecky KK

    更新日期:2004-12-01 00:00:00

  • Type II endoleak after endoaortic graft implantation: diagnosis with helical CT arteriography.

    abstract:PURPOSE:To retrospectively assess endoleak shapes and locations within aneurysms to differentiate type II from type I and type III endoleaks. MATERIALS AND METHODS:The institutional review board granted an exemption for this HIPAA-compliant study; patient informed consent was not required. A retrospective review of ar...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2403051013

    authors: Chernyak V,Rozenblit AM,Patlas M,Cynamon J,Ricci ZJ,Laks MP,Veith FJ

    更新日期:2006-09-01 00:00:00

  • Preshaped catheters for percutaneous transaxillary selective coronary arteriography.

    abstract::Percutaneous transaxillary selective coronary arteriography using preshaped catheters is useful in patients who have had aorto-iliac surgery or have clinical evidence of occlusive arterial disease of the lower extremities. For safety and ease of performance it compares favorably with the percutaneous transfemoral meth...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/114.3.732

    authors: Brown OL

    更新日期:1975-03-01 00:00:00

  • Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images.

    abstract::Sixteen patients with cirrhosis of the liver underwent cranial magnetic resonance (MR) imaging and transarterial portography to evaluate the relationship between basal ganglia lesions and portal-systemic collateral vessels. No neuropsychiatric disturbance was observed in any of the patients at the time of the MR exami...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.179.2.2014310

    authors: Inoue E,Hori S,Narumi Y,Fujita M,Kuriyama K,Kadota T,Kuroda C

    更新日期:1991-05-01 00:00:00

  • Imaging of the gallbladder, 1987.

    abstract::Gallbladder disease, and the patients with symptoms suggestive of gallbladder disease, remains a widespread clinical problem that requires investigation by imaging techniques. Sonography, and to a lesser extent cholescintigraphy, has facilitated the evaluation of these patients and allows the diagnosis of cholelithias...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.163.3.3554340

    authors: Cooperberg PL,Gibney RG

    更新日期:1987-06-01 00:00:00

  • Lateral arcuate ligaments of the diaphragm: anatomic variations at abdominal CT.

    abstract::The authors have occasionally observed nodular areas abutting the lateral diaphragmatic surface and extending into the posterior pararenal space on computed tomographic (CT) scans. Review of the anatomy literature revealed that this finding represents inferolateral extension of the lateral arcuate ligaments, which ref...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.185.1.1523290

    authors: Silverman PM,Cooper C,Zeman RK

    更新日期:1992-10-01 00:00:00

  • Small-vessel radiography in situ with monochromatic synchrotron radiation.

    abstract:PURPOSE:To evaluate the usefulness of a radiographic system with monochromatic synchrotron radiation to depict small vessels and peripheral secretory ducts. MATERIALS AND METHODS:Radiography of various organs was tested in 14 anesthetized dogs and pancreatography was performed in an excised human pancreas by using the...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.201.1.8816540

    authors: Mori H,Hyodo K,Tanaka E,Uddin-Mohammed M,Yamakawa A,Shinozaki Y,Nakazawa H,Tanaka Y,Sekka T,Iwata Y,Handa S,Umetani K,Ueki H,Yokoyama T,Tanioka K,Kubota M,Hosaka H,Ishikawa N,Ando M

    更新日期:1996-10-01 00:00:00

  • Polytomoencephalography of the optic chiasm and adjacent structures.

    abstract::The addition of polytomography considerably increases the sensitivity of pneumoencephalography. The chiasmatic area lends itself particularly well to investigation by polytomoencephalography. In a series of 28 patients, the transverse dimension of the optic chiasm ranged from 4 to 20 mm, with a mean of 18 mm. The post...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/114.3.629

    authors: Johnson JC,Lubow M,Stears J

    更新日期:1975-03-01 00:00:00