Abstract:
:Functions of non-coding RNAs are related in part to their secondary structures. We investigate the uniqueness of the secondary structure of a non-coding RNA (ncRNA) decoding UAG to read pyrrolysine (pyl). Nineteen archaeal methanogens are searched with our tRNA-pyl-tracker, TPYLT, perl-script downloadable from www.gyanxet.com. We observe that aside from the usual pyl-gene-cluster, pyl-carrying Methanosarcinaceae have a good number of conjugate-halves from pyl-tRNA (pylT) gene split at 37/38 spread over their genomes. On in silico ligation, the secondary structures of these pairs clone the clover-leaf of pylT of M. barkeri. Of these nineteen methanogens, four, namely, M. stadtmanae, M. kandleri, M. hungatei, and M. thermautotrophicus, have these pairs at levels at or higher than in the pyl-carrying ones. Screening these we arrive at four pairs, i.e., one from each of these four genomes. On ligation, these are close homologs of pylT gene of M. barkeri. The intervening sequences between the split pairs in these four cases are shown to nearly reproduce the known secondary structures at exon-intron boundaries.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Das S,Mukherjee R,Sahoo S,Thakkar R,Chakrabarti Jdoi
10.1080/07391102.2009.10507324subject
Has Abstractpub_date
2009-12-01 00:00:00pages
381-90issue
3eissn
0739-1102issn
1538-0254pii
c4294/Structural-Clones-of-UAG-Decoding-RNA-p-381-journal_volume
27pub_type
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