Regeneration of nicotinamide cofactors for use in organic synthesis.

Abstract:

:The high cost of nicotinamide cofactors requires that they be regenerated in situ when used in preparative enzymatic synthesis. Numerous strategies have been tested for in situ regeneration of reduced and oxidized cofactors. Regeneration of reduced cofactors is relatively straightforward; regeneration of oxidized cofactors is more difficult. This review summarizes methods for preparation of the cofactors, factors influencing their stability and lifetime in solution, methods for their in situ regeneration, and process considerations relevant to their use in synthesis.

authors

Chenault HK,Whitesides GM

doi

10.1007/BF02798431

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

147-97

issue

2

eissn

0273-2289

issn

1559-0291

journal_volume

14

pub_type

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