Clinically Mild Encephalopathy With a Reversible Splenial Lesion Type 2 Caused by Human Herpesvirus 6 Infection.

Abstract:

BACKGROUND:Clinically mild encephalopathy with a reversible splenial lesion (MERS) is the second commonest cause of encephalopathy. Several pathogens have been detected in patients with MERS type 2, such as influenza A and B, but little is known about the proportion of cases of MERS type 2 with this pathogenesis. Human herpesvirus 6 (HHV6) is the second commonest pathogen causing acute encephalopathy. However, HHV6 has not been previously reported in patients with MERS type 2. PATIENT DESCRIPTION:In this report, we describe a five-year-old boy with MERS type 2 caused by HHV6 infection. The present case was diagnosed with MERS type 2 caused by HHV6 infection based on the characteristic clinical course, the results of the virus testing, and imaging findings. DISCUSSION:This is the first description of MERS type 2 caused by HHV6 infection. Although there is a report of MERS type 1 caused by HHV6 infection, there are no detailed reports in the literature about MERS type 2 associated with HHV6 infection. Thus the clinical findings associated with MERS type 2 caused by HHV6 infection are poorly understood. This report indicates that HHV6 can cause MERS type 2.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Sano F,Fukao T,Tamaru K,Kanemura H,Inukai T,Aihara M

doi

10.1016/j.pediatrneurol.2020.08.021

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

43-45

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(20)30304-0

journal_volume

113

pub_type

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