The risk of transfusion-transmitted infections in sub-Saharan Africa.

Abstract:

BACKGROUND:Blood transfusions carry the risk of transmitting infections. This risk has been studied in detail in high-income countries but not in sub-Saharan Africa. This study estimates the risks of acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) from a single unit of blood in sub-Saharan Africa. STUDY DESIGN AND METHODS:A mathematical model was constructed to quantify transfusion risks across 45 sub-Saharan African countries using three components: the risk of a contaminated unit entering the blood supply, the risk that the unit will be given to a susceptible patient, and the risk that receipt of the unit will lead to infection in the recipient. Variables included prevalence of infection in donors, extent of blood testing, test sensitivity, and susceptibility of recipients. Data from the World Health Organization (WHO) African Region and a systematic review of the literature were used to parameterize the model. Uncertainty in the risk estimates was quantified using probabilistic sensitivity analysis. RESULTS:The median overall risks of becoming infected with HIV, HBV, and HCV from a blood transfusion in sub-Saharan Africa were 1, 4.3, and 2.5 infections per 1000 units, respectively. If annual transfusion requirements projected by the WHO were met, transfusions alone would be responsible for 28,595 HBV infections, 16,625 HCV infections, and 6650 HIV infections every year. Sensitivity analysis suggests that the true risks may be even higher. CONCLUSIONS:This study is the first to systematically quantify the risks of transfusion-transmitted infections across sub-Saharan Africa. Although the results are limited by the quality and quantity of available data, these may be the most reliable estimates at this time.

journal_name

Transfusion

journal_title

Transfusion

authors

Jayaraman S,Chalabi Z,Perel P,Guerriero C,Roberts I

doi

10.1111/j.1537-2995.2009.002402.x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

433-42

issue

2

eissn

0041-1132

issn

1537-2995

pii

TRF2402

journal_volume

50

pub_type

杂志文章,评审
  • Translumbar inferior vena cava catheters: safety and efficacy in peripheral blood stem cell transplantation.

    abstract::Most patients who need peripheral blood stem cell transplantation do not have peripheral venous access that would allow apheresis for stem cell collection. Subclavian apheresis catheters have an unacceptably high incidence of thrombosis-related access failure. A technique has been developed for translumbar placement o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30690333481.x

    authors: Haire WD,Lieberman RP,Lund GB,Wieczorek BM,Armitage JO,Kessinger A

    更新日期:1990-07-01 00:00:00

  • The impact of adenine and inventory utilization decisions on blood inventory management.

    abstract::The use of citrate-phosphate-dextrose-adenine as an anticoagulant for whole blood increases the storage period permitted for whole blood and red cells from 21 to 35 days. A simulation model was used to analyze the possible consequences for outdates and shortages of the addition of adenine. The model accepts as input (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23183147306.x

    authors: Cohen MA,Pierskalla WP,Sassetti RJ

    更新日期:1983-01-01 00:00:00

  • New HIV infections from blood transfusions averted in 28 countries supported by PEPFAR blood safety programs, 2004-2015.

    abstract:BACKGROUND:To quantify the impact of the US President's Emergency Plan for AIDS Relief (PEPFAR) on the risk of HIV transmission through infected blood donations in countries supported by PEPFAR blood safety programs. METHODS:Data reported to the World Health Organization Global Database on Blood Safety were analyzed f...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16256

    authors: Mili FD,Teng Y,Shiraishi RW,Yu J,Bock N,Drammeh B,Watts DH,Benech I

    更新日期:2021-01-28 00:00:00

  • Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.

    abstract:BACKGROUND:Red blood cell exchange (RCE) transfusions are a mainstay in the treatment of sickle cell anemia (SCA), and allow a temporary restoration of physiological parameters with respect to erythrocyte oxygen carrying capacity and systems metabolism. Recently, we noted that 1) RCE significantly impacts recipients' m...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15467

    authors: Gehrke S,Shah N,Gamboni F,Kamyszek R,Srinivasan AJ,Gray A,Landrigan M,Welsby I,D'Alessandro A

    更新日期:2019-10-01 00:00:00

  • Anti-Holley (hy): characterization of another example.

    abstract::Anti-Hy, in a serum of a black man who had received multiple blood transfusions, was found to be a warm reactive and polyclonal IgG antibody which did not bind complement in vitro. 51Cr-labeled Hy-positive red blood cells in the patient showed a shortened "2-component" survival curve. Hy antigens were not detected on ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15676082238.x

    authors: Hsu TC,Jagathambal K,Sabo BH,Sawitsky A

    更新日期:1975-11-01 00:00:00

  • Dengue viremia in blood donors from Honduras, Brazil, and Australia.

    abstract:BACKGROUND:Dengue fever and hemorrhagic disease are caused by four dengue virus (DENV) serotypes (DENV-1 to -4), mosquito-borne flaviviruses with increasing incidence, and expanding global distributions. Documented transfusion transmission of West Nile virus raised concern regarding transfusion-transmitted DENV. METHO...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01772.x

    authors: Linnen JM,Vinelli E,Sabino EC,Tobler LH,Hyland C,Lee TH,Kolk DP,Broulik AS,Collins CS,Lanciotti RS,Busch MP

    更新日期:2008-07-01 00:00:00

  • Effects of prestorage white cell reduction on platelet aggregate formation and the activation state of platelets and plasma enzyme systems.

    abstract:BACKGROUND:The introduction of prestorage white cell (WBC) reduction in random-donor platelet concentrates in Canada has increased the occurrence of particulate material in PCs. The effects of filtration on platelet activation state and the activation of plasma enzyme systems were assessed. STUDY DESIGN AND METHODS:Pa...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39070724.x

    authors: Devine DV,Bradley AJ,Maurer E,Levin E,Chahal S,Serrano K,Gyongyossy-Issa MI

    更新日期:1999-07-01 00:00:00

  • Absence of transfusion-associated microchimerism in pediatric and adult recipients of leukoreduced and gamma-irradiated blood components.

    abstract:BACKGROUND:Transfusion-associated microchimerism (TA-MC), the persistence of significant levels of donor white blood cells (WBCs) in blood recipients for prolonged periods, has been demonstrated after nonleukoreduced and leukoreduced transfusion to patients with severe traumatic injury. Development of TA-MC has not bee...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03366.x

    authors: Sanchez R,Lee TH,Wen L,Montalvo L,Schechterly C,Colvin C,Alter HJ,Luban NL,Busch MP

    更新日期:2012-05-01 00:00:00

  • Interactions of IgM ABO antibodies and complement with methoxy-PEG-modified human RBCs.

    abstract:BACKGROUND:RBCs modified with cyanuric chloride activated methoxy-PEG (CmPEG; 5000 Da) are less immunogenic than untreated RBCs, and their use thus may reduce the risk of alloimmunization in chronically transfused patients. STUDY DESIGN AND METHODS:To further examine the potential utility of CmPEG-RBCs, the effects of...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41101225.x

    authors: Bradley AJ,Test ST,Murad KL,Mitsuyoshi J,Scott MD

    更新日期:2001-10-01 00:00:00

  • Sources and sequelae of bacterial contamination of hematopoietic stem cell components: implications for the safety of hematotherapy and graft engineering.

    abstract:BACKGROUND:It is important to compare the incidence of bacterial contamination of components collected from the peripheral blood or bone marrow (BM), as well as of components processed with or without cell selection or depletion, and to evaluate the sequelae of such contamination. STUDY DESIGN AND METHODS:Bacterial co...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36996420753.x

    authors: Webb IJ,Coral FS,Andersen JW,Elias AD,Finberg RW,Nadler LM,Ritz J,Anderson KC

    更新日期:1996-09-01 00:00:00

  • Recipients of blood from a donor with multiple HLA antibodies: a lookback study of transfusion-related acute lung injury.

    abstract:BACKGROUND:The effects of transfusion of HLA antibodies to patients with corresponding antigens are not well known. STUDY DESIGN AND METHODS:Records of patients who received blood from previous donations of a donor implicated in a case of transfusion-related acute lung injury (TRALI) were examined. The donor had multi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.0041-1132.2004.04193.x

    authors: Toy P,Hollis-Perry KM,Jun J,Nakagawa M

    更新日期:2004-12-01 00:00:00

  • Platelet storage in a plasma-free medium.

    abstract::Currently, platelet concentrates are stored in 50 to 60 ml of plasma. A major drawback to storage in plasma is the considerable loss of platelet function which occurs during storage. A modified Tyrodes medium has been developed for storage of platelets. A comparison between platelet concentrates stored in this medium ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25686071429.x

    authors: Rock G,Swenson SD,Adams GA

    更新日期:1985-11-01 00:00:00

  • Bulk cryopreservation of lymphocytes in glycerol.

    abstract::The authors describe a method for freezing large amounts of peripheral blood lymphocytes (PBL) in a 20 percent glycerol solution. Between 0.6 and 4.3 X 10(9) cells in autologous plasma were frozen in polyethylene freezing bags in a final volume of 50 ml. The recovery after thawing averaged 89 +/- 14 percent with a mea...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28288179020.x

    authors: Areman EM,Simonis TB,Carter CS,Read EJ,Klein HG

    更新日期:1988-03-01 00:00:00

  • Platelet transfusion: automated selection of donors.

    abstract::The selection of platelet donors, according to HLA antigens, has been computerized using a method based on the calculation of incompatibilities and risk of immunization between donors and recipients. Since the risk that an antigen present in a donor will immunize an incompatible recipient of known HLA phenotype, an in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21381201795.x

    authors: Muller JY,Cartron JP,Trillot P,Halle L,Roquin H

    更新日期:1981-05-01 00:00:00

  • Anti-D alloimmunization after D-mismatched allogeneic hematopoietic stem cell transplantation in patients with hematologic diseases.

    abstract:BACKGROUND:The de novo development of anti-D after D-mismatched allogeneic hematopoietic stem cell transplantation (AHSCT) is a possibility that must be considered. The transfusion of D- blood components after AHSCT has been recommended but anti-D alloimmunization in this setting has been studied little. Thus, the aim ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00698.x

    authors: Cid J,Lozano M,Fernández-Avilés F,Carreras E,Pereira A,Mazzara R,Ordinas A

    更新日期:2006-02-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report.

    abstract:BACKGROUND:Platelet transfusion-associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin-resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT:A 54-year-old man, terminally ill with progressive non-H...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41111426.x

    authors: Sapatnekar S,Wood EM,Miller JP,Jacobs MR,Arduino MJ,McAllister SK,Kellum ME,Roth V,Yomtovian R

    更新日期:2001-11-01 00:00:00

  • Improving platelet supply chains through collaborations between blood centers and transfusion services.

    abstract:BACKGROUND:Blood centers and hospital transfusion services are challenged with maintaining an adequate platelet (PLT) inventory to minimize the number of outdated units without risking a major shortage. A novel approach to inventory management was established at our institution through a collaboration between the Stanf...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02236.x

    authors: Fontaine MJ,Chung YT,Rogers WM,Sussmann HD,Quach P,Galel SA,Goodnough LT,Erhun F

    更新日期:2009-10-01 00:00:00

  • Mitochondrial damage-associated molecular patterns as potential proinflammatory mediators in post-platelet transfusion adverse effects.

    abstract:BACKGROUND:Platelet concentrates (PCs) are the most common blood components eliciting nonhemolytic transfusion reactions (NHTRs), such as allergic transfusion reactions and febrile reactions. However, the precise mechanisms of NHTRs in PC transfusion remain largely unknown. Previous studies reported that mitochondria-d...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13535

    authors: Yasui K,Matsuyama N,Kuroishi A,Tani Y,Furuta RA,Hirayama F

    更新日期:2016-05-01 00:00:00

  • Blood safety and availability: continuing challenges in China's blood banking system.

    abstract::Social and economic development, along with increased health care coverage, has caused a sharp increase in the clinical demand for blood in China. Whole blood collection has increased rapidly in the past decade but has failed to keep pace with the ever-increasing demand. Overall, the country's blood safety has been im...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12273

    authors: Shi L,Wang JX,Stevens L,Ness P,Shan H

    更新日期:2014-02-01 00:00:00

  • The effect of adenine on platelet storage.

    abstract::Adenine is an approved additive to citrate-phosphate-dextrose anticoagulant for whole blood collection and extends the storage life of red blood cells. We used in vitro methods to investigate the effects of adenine on platelet function and viability during 72 hours of storage at 22 degrees C. Although the hypotonic sh...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22482251208.x

    authors: Wong SC,Rock G

    更新日期:1982-07-01 00:00:00

  • Removal of Yersinia enterocolitica from AS-1 red cells.

    abstract::The growth of Yersinia enterocolitica in AS-1 red cells was investigated so as to study the organism's proliferation kinetics and to evaluate the effect of prestorage white cell (WBC) reduction on bacterial multiplication. Twenty-four 2-unit pools of ABO-compatible whole blood were prepared and inoculated with Y. ente...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32792391043.x

    authors: Buchholz DH,AuBuchon JP,Snyder EL,Kandler R,Edberg S,Piscitelli V,Pickard C,Napychank P

    更新日期:1992-09-01 00:00:00

  • Enhancing blood donor skin disinfection using natural oils.

    abstract:BACKGROUND:Effective donor skin disinfection is essential in preventing bacterial contamination of blood components with skin flora bacteria like Staphylococcus epidermidis. Cell aggregates of S. epidermidis (biofilms) are found on the skin and are resistant to the commonly used donor skin disinfectants chlorhexidine-g...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14298

    authors: Alabdullatif M,Boujezza I,Mekni M,Taha M,Kumaran D,Yi QL,Landoulsi A,Ramirez-Arcos S

    更新日期:2017-12-01 00:00:00

  • A comparison of four commercial test kits for detection of cytomegalovirus antibodies in blood donors.

    abstract::Four commercial test kits for detecting cytomegalovirus (CMV) antibodies (indirect hemagglutination assay, indirect fluorescent antibody technique, enzyme immunoassay, and passive latex agglutination technique) were compared according to their technical demand, hands-on time, turnaround time, concordance with other te...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26286152916.x

    authors: Feng CS,Williams IB,Gohd RS,Causey AP

    更新日期:1986-03-01 00:00:00

  • Blood supply safety in Afghanistan: a national assessment of high-volume facilities.

    abstract:BACKGROUND:Little information is available regarding blood supply safety in Afghanistan. The purpose of this study was to assess blood safety through serologic and observational measures in Afghanistan. STUDY DESIGN AND METHODS:This cross-sectional assessment included the 40 highest-volume facilities collecting and tr...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12005

    authors: Mansoor GF,Rahmani AM,Kakar MA,Hashimy P,Abrahimi P,Scott PT,Peel SA,Rentas FJ,Todd CS

    更新日期:2013-09-01 00:00:00

  • Comparative evaluation of supplemental hepatitis C virus antibody test systems.

    abstract::Implementation of routine blood donor screening using anti-hepatitis C virus (HCV) enzyme immunoassay (EIA) has resulted in an urgent need for well-characterized supplemental assays to confirm the presence of HCV antibodies. A comparative study of four commercially available supplemental assays is reported here: first...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32592327712.x

    authors: Evans CS,Tobler L,Polito A,Stewart J,Chien D,Wilber J,Quan S,Delaney S,Kuo G,Busch MP

    更新日期:1992-06-01 00:00:00

  • Anti-K formation is not associated with the storage time of transfused red blood cells.

    abstract:BACKGROUND:The formation of red blood cell (RBC) antibodies could be enhanced by the presence of inflammation caused by prolonged RBC storage, as was shown in animal studies. The low occurrence (<10%) of K-antigen in most populations often enables identification of the K+ RBC unit that triggered anti-K formation and de...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12974

    authors: Hogervorst E,Middelburg R,Brand A,van de Watering L,Schonewille H

    更新日期:2015-06-01 00:00:00

  • Transfusion-related acute lung injury caused by an NB2 granulocyte-specific antibody in a patient with thrombotic thrombocytopenic purpura.

    abstract::HLA and granulocyte-specific antibodies have been implicated in the production of transfusion-related acute lung injury (TRALI). Reported here is a case that suggests that the patient's preexisting condition may play an important role in determining whether TRALI develops upon transfusion of blood products containing ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30190117629.x

    authors: Van Buren NL,Stroncek DF,Clay ME,McCullough J,Dalmasso AP

    更新日期:1990-01-01 00:00:00

  • In vitro safety profile of G-CSF-mobilized whole blood after storage for 7 days in an infusable-grade L15 medium.

    abstract:BACKGROUND:G-CSF-mobilized whole blood (WB) is a cost-reducing and simple alternative for peripheral blood progenitor cell transplantation. Recently, it was demonstrated that mobilized WB supplemented with Leibovitz's L15 medium permitted prolonged preservation of clonogenic cells at ambient temperature. In this study,...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1525-1438.2002.00064.x

    authors: de Kreuk AM,Jonkhoff AR,Zevenbergen A,Wilhelm AJ,van Oostveen JW,Schuurhuis GJ,Huijgens PC

    更新日期:2002-04-01 00:00:00

  • A comparative study of the postoperative allogeneic blood-sparing effects of tranexamic acid and of desmopressin after total knee replacement.

    abstract:BACKGROUND:Tissue hypoxia and reperfusion induce abnormal hemostatic function. Therefore, bleeding after total knee replacement (TKR) may be a result of a tourniquet-induced imbalance of the procoagulant and fibrinolytic systems. Because laboratory confirmation of tourniquet-induced abnormal hemostasis is difficult to ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2001.41101285.x

    authors: Zohar E,Fredman B,Ellis MH,Ifrach N,Stern A,Jedeikin R

    更新日期:2001-10-01 00:00:00

  • Evaluation of a new polyacrolein microsphere (acrobead) protein A column: an in vitro study using the blood of patients with immune thrombocytopenia or malignancies.

    abstract::The present study describes the use of a new polyacrolein microsphere (acrobead) protein A column. This method enables immunomodulation by the perfusion of whole blood. The efficacy of the column and its adverse effects following perfusion of blood of patients with immune thrombocytopenic purpura (ITP) or malignancies...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32392213802.x

    authors: Dvilansky A,Aharon M,Riesenfeld G,Nathan I

    更新日期:1992-03-01 00:00:00