Abstract:
:Rabies virus was isolated by cell culture from the brains of 104 confirmed rabies cases diagnosed by the fluorescent-antibody staining technique in the United States during 1974-1984. Eighty-seven isolates were obtained from wild-life species, 10 from humans, and seven from domestic animals. These isolates were tested in virus neutralization and immunofluorescence assays using a panel of 34 monoclonal antibodies specific for rabies virus nucleocapsid protein, 44 monoclonal antibodies specific for rabies virus glycoprotein, and two monoclonal antibodies specific for rabies virus nucleocapsid-associated phosphoprotein. Using discriminant analysis, a distinctly different reactivity pattern was revealed between virus isolates from terrestrial (raccoon, skunk) and nonterrestrial (bat) reservoir hosts. The usefulness of this approach for studying the epidemiology of rabies and for predicting the source of infection when this information is unknown is discussed.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Rupprecht CE,Glickman LT,Spencer PA,Wiktor TJdoi
10.1093/aje/126.2.298subject
Has Abstractpub_date
1987-08-01 00:00:00pages
298-309issue
2eissn
0002-9262issn
1476-6256journal_volume
126pub_type
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