Abstract:
:Homeostasis and integrity of bowel mucosa is assured by well controlled mechanical, biochemical and immunological mechanisms. First line of defense is presented by the antimicrobial peptides (AMP), which form a continuous layer on the bowel surface, produced by intestinal specific (Paneth) and non-specific epithelial cells. AMPs have a significant antimicrobial, antifungal and antiviral, as well as immunomodulatory effects. Next line of defense is the pattern recognition receptors (PRR), which allows identifying conservative molecular patterns of different pathogens, and starts antimicrobial and inflammatory mechanisms through gene-expression induction. We review the most recent knowledge and studies concerning these mechanisms.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Lapis Kdoi
10.1556/OH.2009.28737subject
Has Abstractpub_date
2009-11-22 00:00:00pages
2146-9issue
47eissn
0030-6002issn
1788-6120pii
VU0G21207N7L4103journal_volume
150pub_type
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