[Role of antimicrobial peptides (AMP) and pattern recognition receptors (PRR) in the intestinal mucosa homeostasis].

Abstract:

:Homeostasis and integrity of bowel mucosa is assured by well controlled mechanical, biochemical and immunological mechanisms. First line of defense is presented by the antimicrobial peptides (AMP), which form a continuous layer on the bowel surface, produced by intestinal specific (Paneth) and non-specific epithelial cells. AMPs have a significant antimicrobial, antifungal and antiviral, as well as immunomodulatory effects. Next line of defense is the pattern recognition receptors (PRR), which allows identifying conservative molecular patterns of different pathogens, and starts antimicrobial and inflammatory mechanisms through gene-expression induction. We review the most recent knowledge and studies concerning these mechanisms.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Lapis K

doi

10.1556/OH.2009.28737

subject

Has Abstract

pub_date

2009-11-22 00:00:00

pages

2146-9

issue

47

eissn

0030-6002

issn

1788-6120

pii

VU0G21207N7L4103

journal_volume

150

pub_type

杂志文章,评审
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  • [Burnout among Hungarian physicians. Who are the most at risk?].

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    authors: Kovács A,Horváth OP,Fehér A,Szendrényi V,Méray J,Mari A

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    doi:

    authors: Oláh T,Horváth Ors P

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  • [Health behavior change: motivational interviewing].

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    doi:10.1556/650.2017.30825

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    doi:

    authors: Balázs A,Kokas P,Miklós I,Kupcsulik P

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    authors: Radó J,Arányi J,Deák G,Rétai G

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  • [Decreased first-phase secretion of insulin may play a role in the development of insulin resistance].

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    doi:

    authors: Wittmann I,Soltész G,Jermendy G,Nagy J

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    authors: Szabó L,Borbás E

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  • [Value of the Medicor CT 0100 equipment in a county hospital in the diagnosis of cerebrovascular diseases].

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    doi:

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  • [Epidemiology of inflammatory bowel diseases in Veszprém county of Western Hungary between 1977 and 2001].

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    doi:

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  • [Experiences with a new vacuum-accelerated microwave histoprocessor].

    abstract::Methods of microwave and vacuum accelerated fixation, dehydration and paraffin embedding are described. They can be carried out in a new type of vacuum and temperature stabilizable microwave histoprocessor: MFX-800. The whole histoprocessing lasts 3.5-5.5 hours depending on the thickness of the tissue blocks. Preserve...

    journal_title:Orvosi hetilap

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    doi:

    authors: Kovács L,Szende B,Elek G,Lapis K,Horváth O,Hiszek I,Tamási A,Schmidt O

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  • [Public health control of hyperhomocysteinemia and its consequences].

    abstract::The etiological role of hyperhomocysteinemia in the origin of neural-tube defects was proved, therefore a mandatory flour folic acid fortification program was introduced in the USA since January 1, 1998. In Hungary one kind of breads was fortified with folic acid, vitamin B12 and vitamin B6. The Hungarian randomised c...

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    pub_type: 杂志文章,评审

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  • [Vena cava superior syndrome: surgical treatment of the thrombosis of the superior vena cava after implantation of a hemodialysis catheter--a case report and review of the literature].

    abstract::One of the rare reasons of the non malignant superior vena cava syndrome is the thrombosis of superior vena cava. Obstruction or occlusion of central veins is one of the many complications of the more and more frequently used central venous catheters and pacemaker electrodes. The authors report a case of superior vena...

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  • [How do Hungarian family physicians think about Helicobacter pylori? Results of national survey].

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  • [Tyrosine kinase inhibitor STI571: new possibility in the treatment of chronic myeloid leukemia].

    abstract::Chronic myeloid leukemia shown to be associated with the Ph translocation,--characterised as a t(9;22)--, joins the bcr and abl genes and leads to expression of chimeric BCR-ABL protein with enhanced tyrosine kinase (TK) activity. This increased TK activity leads to malignant transformation by interference with the co...

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    authors: Molnár L,Losonczy H

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  • [Examination of attitudes towards transplantation among patients with chronic renal failure].

    abstract::The patients' attitudes towards kidney transplantation are significantly affected by the acceptance of the treatment to have a better quality of life. Exploration of the cognitive-emotional relation in patients with chronic renal failure. Our study included 285 kidney patients. We investigated three groups of patients...

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  • [Autoimmune side effects of immune-checkpoint inhibitor therapies in oncology: pathogenesis, clinic and treatment].

    abstract::Oncotherapy has been revolutionised by the introduction of immune-checkpoint inhibitors including CTLA4, PD1 and PDL1 inhibitors. Patients with malignant diseases may largely benefit from these therapies, which may result in long-term remission even in the most therapy-resistant tumour types. Differences in the mode o...

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  • [Atrial fibrillation and the autonomous nervous system].

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  • [Migration of an epicardial pacemaker into the abdominal cavity].

    abstract::Migration of a permanent pacemaker generator from their intramuscular pocket to the abdominal cavity is a less frequent, but potentially life-threatening complication. The authors present the case of a 69-year-old woman, who visited the emergency department of the clinic, with complains of non-specific abdominal sympt...

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  • [Endoscopic ligation of bleeding esophageal varices].

    abstract::Endoscopic variceal ligation (EVL) is a new method for treating oesophageal varices, which was developed to reduce the high complication rate seen with endoscopic sclerotherapy. This technique consists of mechanical occlusion and thrombosis applying small elastic bands around the variceal channels in the distal oesoph...

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  • [Nephrogenic diabetes insipidus].

    abstract::The syndrome of polyuria and polydipsia is practically identical in three very different disorders (central diabetes insipidus, nephrogenic diabetes insipidus, primary polydipsia). In congenital nephrogenic diabetes insipidus both the thirst mechanism and the production of the antidiuretic hormone are intact, but the ...

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    doi:

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  • [Effect of loratadine in children with allergic rhinitis].

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  • [Cerebral blood flow studied by SPECT and transcranial Doppler sonography in subarachnoid hemorrhage].

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